Exploring physical determinants of premetastatic niche with organotypic metastasis-on-a-chip

Chun Wei Lee, Hsueh Yao Chu, Ming Hsuan Chiu, Yin Ju Chen, Long Sheng Lu, Fan Gang Tseng

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This research is to develop a novel organotypic metastases-on-a-chip to understand how biophysical factors contribute to the formation of a premetastatic niche. A premetastatic niche refers to the unique microenvironment in destiny organs that receives metastatic cancer cells. Understanding its physical determinants may add to facilitate discovery of potential microenvironment modifiers as new anti-metastasis strategy. we have manufactured and characterized an alginate hydrogel tube (AHT), a manufacturing process based on divalent ion curing will give rise to AHTs with combination of physical properties including submicron surface topography, stiffness, and molecular sieve pore size. The process parameters will be optimized to obtain biomimetic physical properties of the bone marrow microenvironment. Based on studies on tumor microenvironment and our preliminary results.

Original languageEnglish
Title of host publication22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
PublisherChemical and Biological Microsystems Society
Pages1579-1581
Number of pages3
ISBN (Electronic)9781510897571
Publication statusPublished - Jan 1 2018
Event22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018 - Kaohsiung, Taiwan
Duration: Nov 11 2018Nov 15 2018

Publication series

Name22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
Volume3

Conference

Conference22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
CountryTaiwan
CityKaohsiung
Period11/11/1811/15/18

Keywords

  • Biomimetic hydrogel tubes
  • Metastatic cancer
  • Organ-on-a-chip
  • Premetastatic niche
  • Tissue engineering

ASJC Scopus subject areas

  • Chemistry(all)
  • Bioengineering
  • Chemical Engineering (miscellaneous)
  • Control and Systems Engineering

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  • Cite this

    Lee, C. W., Chu, H. Y., Chiu, M. H., Chen, Y. J., Lu, L. S., & Tseng, F. G. (2018). Exploring physical determinants of premetastatic niche with organotypic metastasis-on-a-chip. In 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018 (pp. 1579-1581). (22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018; Vol. 3). Chemical and Biological Microsystems Society.