Exploring association between statin use and breast cancer risk

an updated meta-analysis

Md Mohaimenul Islam, Hsuan Chia Yang, Phung Anh Nguyen, Tahmina Nasrin Poly, Chih Wei Huang, Shwetambara Kekade, Abdulwahed Mohammed Khalfan, Tonmoy Debnath, Yu Chuan Jack Li, Shabbir Syed Abdul

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Purpose: The benefits of statin treatment for preventing cardiac disease are well established. However, preclinical studies suggested that statins may influence mammary cancer growth, but the clinical evidence is still inconsistent. We, therefore, performed an updated meta-analysis to provide a precise estimate of the risk of breast cancer in individuals undergoing statin therapy. Methods: For this meta-analysis, we searched PubMed, the Cochrane Library, Web of Science, Embase, and CINAHL for published studies up to January 31, 2017. Articles were included if they (1) were published in English; (2) had an observational study design with individual-level exposure and outcome data, examined the effect of statin therapy, and reported the incidence of breast cancer; and (3) reported estimates of either the relative risk, odds ratios, or hazard ratios with 95% confidence intervals (CIs). We used random-effect models to pool the estimates. Results: Of 2754 unique abstracts, 39 were selected for full-text review, and 36 studies reporting on 121,399 patients met all inclusion criteria. The overall pooled risks of breast cancer in patients using statins were 0.94 (95% CI 0.86–1.03) in random-effect models with significant heterogeneity between estimates (I2 = 83.79%, p = 0.0001). However, we also stratified by region, the duration of statin therapy, methodological design, statin properties, and individual stain use. Conclusions: Our results suggest that there is no association between statin use and breast cancer risk. However, observational studies cannot clarify whether the observed epidemiologic association is a causal effect or the result of some unmeasured confounding variable. Therefore, more research is needed.

Original languageEnglish
Pages (from-to)1-11
Number of pages11
JournalArchives of Gynecology and Obstetrics
DOIs
Publication statusAccepted/In press - Sep 22 2017

Fingerprint

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Meta-Analysis
Breast Neoplasms
Odds Ratio
Observational Studies
Library Science
Confidence Intervals
Confounding Factors (Epidemiology)
Therapeutics
PubMed
Heart Diseases
Coloring Agents
Incidence

Keywords

  • Breast cancer
  • Heterogeneity
  • Meta-analysis
  • Relative risk
  • Statin

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Exploring association between statin use and breast cancer risk : an updated meta-analysis. / Islam, Md Mohaimenul; Yang, Hsuan Chia; Nguyen, Phung Anh; Poly, Tahmina Nasrin; Huang, Chih Wei; Kekade, Shwetambara; Khalfan, Abdulwahed Mohammed; Debnath, Tonmoy; Li, Yu Chuan Jack; Abdul, Shabbir Syed.

In: Archives of Gynecology and Obstetrics, 22.09.2017, p. 1-11.

Research output: Contribution to journalArticle

Islam, Md Mohaimenul ; Yang, Hsuan Chia ; Nguyen, Phung Anh ; Poly, Tahmina Nasrin ; Huang, Chih Wei ; Kekade, Shwetambara ; Khalfan, Abdulwahed Mohammed ; Debnath, Tonmoy ; Li, Yu Chuan Jack ; Abdul, Shabbir Syed. / Exploring association between statin use and breast cancer risk : an updated meta-analysis. In: Archives of Gynecology and Obstetrics. 2017 ; pp. 1-11.
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abstract = "Purpose: The benefits of statin treatment for preventing cardiac disease are well established. However, preclinical studies suggested that statins may influence mammary cancer growth, but the clinical evidence is still inconsistent. We, therefore, performed an updated meta-analysis to provide a precise estimate of the risk of breast cancer in individuals undergoing statin therapy. Methods: For this meta-analysis, we searched PubMed, the Cochrane Library, Web of Science, Embase, and CINAHL for published studies up to January 31, 2017. Articles were included if they (1) were published in English; (2) had an observational study design with individual-level exposure and outcome data, examined the effect of statin therapy, and reported the incidence of breast cancer; and (3) reported estimates of either the relative risk, odds ratios, or hazard ratios with 95{\%} confidence intervals (CIs). We used random-effect models to pool the estimates. Results: Of 2754 unique abstracts, 39 were selected for full-text review, and 36 studies reporting on 121,399 patients met all inclusion criteria. The overall pooled risks of breast cancer in patients using statins were 0.94 (95{\%} CI 0.86–1.03) in random-effect models with significant heterogeneity between estimates (I2 = 83.79{\%}, p = 0.0001). However, we also stratified by region, the duration of statin therapy, methodological design, statin properties, and individual stain use. Conclusions: Our results suggest that there is no association between statin use and breast cancer risk. However, observational studies cannot clarify whether the observed epidemiologic association is a causal effect or the result of some unmeasured confounding variable. Therefore, more research is needed.",
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T2 - an updated meta-analysis

AU - Islam, Md Mohaimenul

AU - Yang, Hsuan Chia

AU - Nguyen, Phung Anh

AU - Poly, Tahmina Nasrin

AU - Huang, Chih Wei

AU - Kekade, Shwetambara

AU - Khalfan, Abdulwahed Mohammed

AU - Debnath, Tonmoy

AU - Li, Yu Chuan Jack

AU - Abdul, Shabbir Syed

PY - 2017/9/22

Y1 - 2017/9/22

N2 - Purpose: The benefits of statin treatment for preventing cardiac disease are well established. However, preclinical studies suggested that statins may influence mammary cancer growth, but the clinical evidence is still inconsistent. We, therefore, performed an updated meta-analysis to provide a precise estimate of the risk of breast cancer in individuals undergoing statin therapy. Methods: For this meta-analysis, we searched PubMed, the Cochrane Library, Web of Science, Embase, and CINAHL for published studies up to January 31, 2017. Articles were included if they (1) were published in English; (2) had an observational study design with individual-level exposure and outcome data, examined the effect of statin therapy, and reported the incidence of breast cancer; and (3) reported estimates of either the relative risk, odds ratios, or hazard ratios with 95% confidence intervals (CIs). We used random-effect models to pool the estimates. Results: Of 2754 unique abstracts, 39 were selected for full-text review, and 36 studies reporting on 121,399 patients met all inclusion criteria. The overall pooled risks of breast cancer in patients using statins were 0.94 (95% CI 0.86–1.03) in random-effect models with significant heterogeneity between estimates (I2 = 83.79%, p = 0.0001). However, we also stratified by region, the duration of statin therapy, methodological design, statin properties, and individual stain use. Conclusions: Our results suggest that there is no association between statin use and breast cancer risk. However, observational studies cannot clarify whether the observed epidemiologic association is a causal effect or the result of some unmeasured confounding variable. Therefore, more research is needed.

AB - Purpose: The benefits of statin treatment for preventing cardiac disease are well established. However, preclinical studies suggested that statins may influence mammary cancer growth, but the clinical evidence is still inconsistent. We, therefore, performed an updated meta-analysis to provide a precise estimate of the risk of breast cancer in individuals undergoing statin therapy. Methods: For this meta-analysis, we searched PubMed, the Cochrane Library, Web of Science, Embase, and CINAHL for published studies up to January 31, 2017. Articles were included if they (1) were published in English; (2) had an observational study design with individual-level exposure and outcome data, examined the effect of statin therapy, and reported the incidence of breast cancer; and (3) reported estimates of either the relative risk, odds ratios, or hazard ratios with 95% confidence intervals (CIs). We used random-effect models to pool the estimates. Results: Of 2754 unique abstracts, 39 were selected for full-text review, and 36 studies reporting on 121,399 patients met all inclusion criteria. The overall pooled risks of breast cancer in patients using statins were 0.94 (95% CI 0.86–1.03) in random-effect models with significant heterogeneity between estimates (I2 = 83.79%, p = 0.0001). However, we also stratified by region, the duration of statin therapy, methodological design, statin properties, and individual stain use. Conclusions: Our results suggest that there is no association between statin use and breast cancer risk. However, observational studies cannot clarify whether the observed epidemiologic association is a causal effect or the result of some unmeasured confounding variable. Therefore, more research is needed.

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KW - Heterogeneity

KW - Meta-analysis

KW - Relative risk

KW - Statin

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