Exploration of microbiota targets for major depressive disorder and mood related traits

Yu Chu Ella Chung, Hsi Chung Chen, Hsiang Chin Lori Chou, I. Ming Chen, Meei Shyuan Lee, Li Chung Chuang, Yen Wenn Liu, Mong Liang Lu, Chun Hsin Chen, Chi Hsin Wu, Ming Chyi Huang, Shih Cheng Liao, Yen Hsuan Ni, Mei Shu Lai, Wei Liang Shih, Po Hsiu Kuo

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Growing evidence suggests the link between gut microbiota and mood regulation. The current study aimed to identify microbiota targets for major depressive disorder (MDD) and mood-related traits in Taiwanese samples, while taking into account the influence of dietary patterns. We recruited 36 MDD patients and 37 healthy controls for 16S rRNA gene sequencing. We assessed nutrient content using food frequency questionnaire, and mood related phenotypes, including depressive severity, anxiety, and perceived stress. Analysis of composition of microbiomes (ANCOM) models were performed to evaluate microbiota compositions between patients and controls, while adjusted for fat intake% and sequencing platforms. We found 23 taxa (4 phyla, 7 families and 12 genera) to be associated with depression and beta diversity was differed between groups. Phylum Actinobacteria and Firmicutes were overrepresented in MDD patients. At genus level, Bifidobacterium (7%) and Blautia (8%) had relatively high abundance among MDD patients, while Prevotella (16%) had high abundance in controls. Holdemania exhibited moderate correlation with anxiety (r = 0.65) and perceived stress level (r = 0.49) mainly in MDD patients but not controls. Pathway analyses revealed that pentose phosphate and starch and sucrose metabolism processes were important pathways for depression via microbiota functions. In conclusion, our results revealed microbiota targets for depression that are independent of fat intake. It is worthwhile to conduct further studies to replicate the current findings and to integrate with biochemistry and metabolomics data to better understand the functions of identified targets.

Original languageEnglish
Pages (from-to)74-82
Number of pages9
JournalJournal of Psychiatric Research
Volume111
DOIs
Publication statusPublished - Apr 1 2019

Fingerprint

Microbiota
Major Depressive Disorder
Depression
Anxiety
Fats
Prevotella
Pentoses
Food
Bifidobacterium
Metabolomics
Actinobacteria
rRNA Genes
Starch
Biochemistry
Sucrose
Phosphates
Phenotype

Keywords

  • Anxiety
  • Gut-brain axis
  • Major depressive disorder
  • Microbiota
  • Perceived stress

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Chung, Y. C. E., Chen, H. C., Chou, H. C. L., Chen, I. M., Lee, M. S., Chuang, L. C., ... Kuo, P. H. (2019). Exploration of microbiota targets for major depressive disorder and mood related traits. Journal of Psychiatric Research, 111, 74-82. https://doi.org/10.1016/j.jpsychires.2019.01.016

Exploration of microbiota targets for major depressive disorder and mood related traits. / Chung, Yu Chu Ella; Chen, Hsi Chung; Chou, Hsiang Chin Lori; Chen, I. Ming; Lee, Meei Shyuan; Chuang, Li Chung; Liu, Yen Wenn; Lu, Mong Liang; Chen, Chun Hsin; Wu, Chi Hsin; Huang, Ming Chyi; Liao, Shih Cheng; Ni, Yen Hsuan; Lai, Mei Shu; Shih, Wei Liang; Kuo, Po Hsiu.

In: Journal of Psychiatric Research, Vol. 111, 01.04.2019, p. 74-82.

Research output: Contribution to journalArticle

Chung, YCE, Chen, HC, Chou, HCL, Chen, IM, Lee, MS, Chuang, LC, Liu, YW, Lu, ML, Chen, CH, Wu, CH, Huang, MC, Liao, SC, Ni, YH, Lai, MS, Shih, WL & Kuo, PH 2019, 'Exploration of microbiota targets for major depressive disorder and mood related traits', Journal of Psychiatric Research, vol. 111, pp. 74-82. https://doi.org/10.1016/j.jpsychires.2019.01.016
Chung, Yu Chu Ella ; Chen, Hsi Chung ; Chou, Hsiang Chin Lori ; Chen, I. Ming ; Lee, Meei Shyuan ; Chuang, Li Chung ; Liu, Yen Wenn ; Lu, Mong Liang ; Chen, Chun Hsin ; Wu, Chi Hsin ; Huang, Ming Chyi ; Liao, Shih Cheng ; Ni, Yen Hsuan ; Lai, Mei Shu ; Shih, Wei Liang ; Kuo, Po Hsiu. / Exploration of microbiota targets for major depressive disorder and mood related traits. In: Journal of Psychiatric Research. 2019 ; Vol. 111. pp. 74-82.
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AU - Lee, Meei Shyuan

AU - Chuang, Li Chung

AU - Liu, Yen Wenn

AU - Lu, Mong Liang

AU - Chen, Chun Hsin

AU - Wu, Chi Hsin

AU - Huang, Ming Chyi

AU - Liao, Shih Cheng

AU - Ni, Yen Hsuan

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AU - Shih, Wei Liang

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