Exosomes from the tumor microenvironment as reciprocal regulators that enhance prostate cancer progression

Che Ming Liu, Chia Ling Hsieh, Chia Ning Shen, Cheng Chieh Lin, Katsumi Shigemura, Shian Ying Sung

Research output: Contribution to journalReview article

14 Citations (Scopus)

Abstract

Distant organ metastasis of prostate cancer is a puzzle, and various theories have successively arisen to explain the mechanism of lethal cancer progression. While perhaps agreeable to many cancer biologists, the very statement of “seed and soil” proposed by Stephan Paget in 1881 is arguably still the major statement for organ-specific cancer metastasis. Since recent studies showed important correlations of regulation of cancer cells and the microenvironment, exosomes from cancer and stromal cells seem to create another important niche for metastasis. Stromal cells pretreated with exosomes from metastatic cancer cells increase the potential of change stromal cells. The poorly metastatic cancer cells could also enhance malignancy through transfer of proteins, microribonucleic acid and messenger ribonucleic acid to recipient cancer cells. Herein, we reviewed extracellular exosomes as a factor involved in cross-talk between stromal and prostate cancer epithelial cells.

Original languageEnglish
Pages (from-to)734-744
Number of pages11
JournalInternational Journal of Urology
Volume23
Issue number9
DOIs
Publication statusPublished - Sep 1 2016

Fingerprint

Exosomes
Tumor Microenvironment
Prostatic Neoplasms
Neoplasms
Stromal Cells
Neoplasm Metastasis
Cellular Microenvironment
Seeds
Soil
Epithelial Cells
RNA
Acids

Keywords

  • exosome
  • microvesicle
  • prostate cancer
  • tumor microenvironment

ASJC Scopus subject areas

  • Urology

Cite this

Exosomes from the tumor microenvironment as reciprocal regulators that enhance prostate cancer progression. / Liu, Che Ming; Hsieh, Chia Ling; Shen, Chia Ning; Lin, Cheng Chieh; Shigemura, Katsumi; Sung, Shian Ying.

In: International Journal of Urology, Vol. 23, No. 9, 01.09.2016, p. 734-744.

Research output: Contribution to journalReview article

Liu, Che Ming ; Hsieh, Chia Ling ; Shen, Chia Ning ; Lin, Cheng Chieh ; Shigemura, Katsumi ; Sung, Shian Ying. / Exosomes from the tumor microenvironment as reciprocal regulators that enhance prostate cancer progression. In: International Journal of Urology. 2016 ; Vol. 23, No. 9. pp. 734-744.
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