Exhaled nitric oxide in a Taiwanese population: Age and lung function as predicting factors

Hsu Chung Liu, Jeng Yuan Hsu, Ya Wen Cheng, Ming Chih Chou

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


Background/Purpose: The fractional concentration of exhaled nitric oxide (FE NO) has been reported to be elevated in asthma and many other lung diseases. The present study investigated reference values and determinants of FE NO in a Taiwanese non-smoking, healthy adult population. Methods: We used a chemiluminescence analyzer according to American Thoracic Society/European Respiratory Society recommendations to measure FE NO values in 356 adults who received a health check-up and a detailed respiratory questionnaire at Taichung Veterans General Hospital, Taiwan. Among the volunteers, 249 fulfilled our definition of healthy adults: no history of smoking or physician-diagnosed asthma; no recent upper airway infection; no chronic respiratory symptoms; and no allergic rhinitis and urticaria. Results: Among the 249 non-smoking and non-asthmatic adults, the mean (5 th to 95 th percentile reference range) FE NO was 27.9 (12.5-58.0) parts per billion. In multivariate regression analyses, age and lung function (forced vital capacity or forced expiratory volume in 1 second) were associated positively with FE NO values. Sex, height, weight, and ambient NO values were not associated significantly with FE NO values. Conclusion: Age and lung function were predictors of FE NO in this population, and these factors should be considered for clinical applications of FE NO measurements.

Original languageEnglish
Pages (from-to)772-777
Number of pages6
JournalJournal of the Formosan Medical Association = Taiwan yi zhi
Issue number10
Publication statusPublished - Oct 2009
Externally publishedYes


  • Age
  • Nitric oxide
  • Pulmonary function tests
  • Reference values

ASJC Scopus subject areas

  • Medicine(all)


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