Abstract
Background/Purpose: The fractional concentration of exhaled nitric oxide (FE NO) has been reported to be elevated in asthma and many other lung diseases. The present study investigated reference values and determinants of FE NO in a Taiwanese non-smoking, healthy adult population. Methods: We used a chemiluminescence analyzer according to American Thoracic Society/European Respiratory Society recommendations to measure FE NO values in 356 adults who received a health check-up and a detailed respiratory questionnaire at Taichung Veterans General Hospital, Taiwan. Among the volunteers, 249 fulfilled our definition of healthy adults: no history of smoking or physician-diagnosed asthma; no recent upper airway infection; no chronic respiratory symptoms; and no allergic rhinitis and urticaria. Results: Among the 249 non-smoking and non-asthmatic adults, the mean (5 th to 95 th percentile reference range) FE NO was 27.9 (12.5-58.0) parts per billion. In multivariate regression analyses, age and lung function (forced vital capacity or forced expiratory volume in 1 second) were associated positively with FE NO values. Sex, height, weight, and ambient NO values were not associated significantly with FE NO values. Conclusion: Age and lung function were predictors of FE NO in this population, and these factors should be considered for clinical applications of FE NO measurements.
| Original language | English |
|---|---|
| Pages (from-to) | 772-777 |
| Number of pages | 6 |
| Journal | Journal of the Formosan Medical Association = Taiwan yi zhi |
| Volume | 108 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - Oct 2009 |
| Externally published | Yes |
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Keywords
- Age
- Nitric oxide
- Pulmonary function tests
- Reference values
ASJC Scopus subject areas
- Medicine(all)
Cite this
Exhaled nitric oxide in a Taiwanese population : Age and lung function as predicting factors. / Liu, Hsu Chung; Hsu, Jeng Yuan; Cheng, Ya Wen; Chou, Ming Chih.
In: Journal of the Formosan Medical Association = Taiwan yi zhi, Vol. 108, No. 10, 10.2009, p. 772-777.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Exhaled nitric oxide in a Taiwanese population
T2 - Age and lung function as predicting factors
AU - Liu, Hsu Chung
AU - Hsu, Jeng Yuan
AU - Cheng, Ya Wen
AU - Chou, Ming Chih
PY - 2009/10
Y1 - 2009/10
N2 - Background/Purpose: The fractional concentration of exhaled nitric oxide (FE NO) has been reported to be elevated in asthma and many other lung diseases. The present study investigated reference values and determinants of FE NO in a Taiwanese non-smoking, healthy adult population. Methods: We used a chemiluminescence analyzer according to American Thoracic Society/European Respiratory Society recommendations to measure FE NO values in 356 adults who received a health check-up and a detailed respiratory questionnaire at Taichung Veterans General Hospital, Taiwan. Among the volunteers, 249 fulfilled our definition of healthy adults: no history of smoking or physician-diagnosed asthma; no recent upper airway infection; no chronic respiratory symptoms; and no allergic rhinitis and urticaria. Results: Among the 249 non-smoking and non-asthmatic adults, the mean (5 th to 95 th percentile reference range) FE NO was 27.9 (12.5-58.0) parts per billion. In multivariate regression analyses, age and lung function (forced vital capacity or forced expiratory volume in 1 second) were associated positively with FE NO values. Sex, height, weight, and ambient NO values were not associated significantly with FE NO values. Conclusion: Age and lung function were predictors of FE NO in this population, and these factors should be considered for clinical applications of FE NO measurements.
AB - Background/Purpose: The fractional concentration of exhaled nitric oxide (FE NO) has been reported to be elevated in asthma and many other lung diseases. The present study investigated reference values and determinants of FE NO in a Taiwanese non-smoking, healthy adult population. Methods: We used a chemiluminescence analyzer according to American Thoracic Society/European Respiratory Society recommendations to measure FE NO values in 356 adults who received a health check-up and a detailed respiratory questionnaire at Taichung Veterans General Hospital, Taiwan. Among the volunteers, 249 fulfilled our definition of healthy adults: no history of smoking or physician-diagnosed asthma; no recent upper airway infection; no chronic respiratory symptoms; and no allergic rhinitis and urticaria. Results: Among the 249 non-smoking and non-asthmatic adults, the mean (5 th to 95 th percentile reference range) FE NO was 27.9 (12.5-58.0) parts per billion. In multivariate regression analyses, age and lung function (forced vital capacity or forced expiratory volume in 1 second) were associated positively with FE NO values. Sex, height, weight, and ambient NO values were not associated significantly with FE NO values. Conclusion: Age and lung function were predictors of FE NO in this population, and these factors should be considered for clinical applications of FE NO measurements.
KW - Age
KW - Nitric oxide
KW - Pulmonary function tests
KW - Reference values
UR - http://www.scopus.com/inward/record.url?scp=74049101701&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=74049101701&partnerID=8YFLogxK
U2 - 10.1016/S0929-6646(09)60404-6
DO - 10.1016/S0929-6646(09)60404-6
M3 - Article
C2 - 19864197
AN - SCOPUS:74049101701
VL - 108
SP - 772
EP - 777
JO - Journal of the Formosan Medical Association
JF - Journal of the Formosan Medical Association
SN - 0929-6646
IS - 10
ER -