Exercise training with negative pressure ventilation improves exercise capacity in patients with severe restrictive lung disease: A prospective controlled study

Shu Chuan Ho, Horng Chyuan Lin, Han Pin Kuo, Li Fei Chen, Te Fang Sheng, Wen Ching Jao, Chun Hua Wang, Kang Yun Lee

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Exercise training is of benefit for patients with restrictive lung disease. However, it tends to be intolerable for those with severe disease. We examined whether providing ventilatory assistance by using negative pressure ventilators (NPV) during exercise training is feasible for such patients and the effects of training.Methods: 36 patients with restrictive lung disease were prospectively enrolled for a 12-week multidisciplinary rehabilitation program. During this program, half of them (n:18; 60.3 ± 11.6 years; 6 men; FVC: 32.5 ± 11.7% predicted ) received regular sessions of exercise training under NPV, whilst the 18 others (59.6 ± 12.3 years; 8 men; FVC: 37.7 ± 10.2% predicted) did not. Exercise capacity, pulmonary function, dyspnea and quality of life were measured. The primary endpoint was the between-group difference in change of 6 minute-walk distance (6MWD) after 12 weeks of rehabilitation.Results: All patients in the NPV-exercise group were able to tolerate and completed the program. The between-group differences were significantly better in the NPV-exercise group in changes of 6MWD (34.1 ± 12.7 m vs. -32.5 ± 17.5 m; P = 0.011) and St George Score (-14.5 ± 3.6 vs. 11.8 ± 6.0; P <0.01). There was an improvement in dyspnea sensation (Borg's scale, from 1.4 ± 1.5 point to 0.8 ± 1.3 point, P = 0.049) and a small increase in FVC (from 0.85 ± 0.09 L to 0.91 ± 0.08 L, P = 0.029) in the NPV-exercise group compared to the control group.Conclusion: Exercise training with NPV support is feasible for patients with severe restrictive lung diseases, and improves exercise capacity and health-related quality of life.

Original languageEnglish
Article number22
JournalRespiratory Research
Volume14
Issue number1
DOIs
Publication statusPublished - Feb 19 2013
Externally publishedYes

Fingerprint

Negative-Pressure Ventilators
Lung Diseases
Ventilation
Prospective Studies
Exercise
Pressure
Dyspnea
Rehabilitation
Quality of Life
Lung
Control Groups

Keywords

  • Exercise capacity
  • Exercise training
  • Health-related quality of life
  • Negative pressure ventilation
  • Restrictive lung disease

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Exercise training with negative pressure ventilation improves exercise capacity in patients with severe restrictive lung disease : A prospective controlled study. / Ho, Shu Chuan; Lin, Horng Chyuan; Kuo, Han Pin; Chen, Li Fei; Sheng, Te Fang; Jao, Wen Ching; Wang, Chun Hua; Lee, Kang Yun.

In: Respiratory Research, Vol. 14, No. 1, 22, 19.02.2013.

Research output: Contribution to journalArticle

@article{117474985d7f430da6850b89d4c6b500,
title = "Exercise training with negative pressure ventilation improves exercise capacity in patients with severe restrictive lung disease: A prospective controlled study",
abstract = "Background: Exercise training is of benefit for patients with restrictive lung disease. However, it tends to be intolerable for those with severe disease. We examined whether providing ventilatory assistance by using negative pressure ventilators (NPV) during exercise training is feasible for such patients and the effects of training.Methods: 36 patients with restrictive lung disease were prospectively enrolled for a 12-week multidisciplinary rehabilitation program. During this program, half of them (n:18; 60.3 ± 11.6 years; 6 men; FVC: 32.5 ± 11.7{\%} predicted ) received regular sessions of exercise training under NPV, whilst the 18 others (59.6 ± 12.3 years; 8 men; FVC: 37.7 ± 10.2{\%} predicted) did not. Exercise capacity, pulmonary function, dyspnea and quality of life were measured. The primary endpoint was the between-group difference in change of 6 minute-walk distance (6MWD) after 12 weeks of rehabilitation.Results: All patients in the NPV-exercise group were able to tolerate and completed the program. The between-group differences were significantly better in the NPV-exercise group in changes of 6MWD (34.1 ± 12.7 m vs. -32.5 ± 17.5 m; P = 0.011) and St George Score (-14.5 ± 3.6 vs. 11.8 ± 6.0; P <0.01). There was an improvement in dyspnea sensation (Borg's scale, from 1.4 ± 1.5 point to 0.8 ± 1.3 point, P = 0.049) and a small increase in FVC (from 0.85 ± 0.09 L to 0.91 ± 0.08 L, P = 0.029) in the NPV-exercise group compared to the control group.Conclusion: Exercise training with NPV support is feasible for patients with severe restrictive lung diseases, and improves exercise capacity and health-related quality of life.",
keywords = "Exercise capacity, Exercise training, Health-related quality of life, Negative pressure ventilation, Restrictive lung disease",
author = "Ho, {Shu Chuan} and Lin, {Horng Chyuan} and Kuo, {Han Pin} and Chen, {Li Fei} and Sheng, {Te Fang} and Jao, {Wen Ching} and Wang, {Chun Hua} and Lee, {Kang Yun}",
year = "2013",
month = "2",
day = "19",
doi = "10.1186/1465-9921-14-22",
language = "English",
volume = "14",
journal = "Respiratory Research",
issn = "1465-9921",
publisher = "BioMed Central",
number = "1",

}

TY - JOUR

T1 - Exercise training with negative pressure ventilation improves exercise capacity in patients with severe restrictive lung disease

T2 - A prospective controlled study

AU - Ho, Shu Chuan

AU - Lin, Horng Chyuan

AU - Kuo, Han Pin

AU - Chen, Li Fei

AU - Sheng, Te Fang

AU - Jao, Wen Ching

AU - Wang, Chun Hua

AU - Lee, Kang Yun

PY - 2013/2/19

Y1 - 2013/2/19

N2 - Background: Exercise training is of benefit for patients with restrictive lung disease. However, it tends to be intolerable for those with severe disease. We examined whether providing ventilatory assistance by using negative pressure ventilators (NPV) during exercise training is feasible for such patients and the effects of training.Methods: 36 patients with restrictive lung disease were prospectively enrolled for a 12-week multidisciplinary rehabilitation program. During this program, half of them (n:18; 60.3 ± 11.6 years; 6 men; FVC: 32.5 ± 11.7% predicted ) received regular sessions of exercise training under NPV, whilst the 18 others (59.6 ± 12.3 years; 8 men; FVC: 37.7 ± 10.2% predicted) did not. Exercise capacity, pulmonary function, dyspnea and quality of life were measured. The primary endpoint was the between-group difference in change of 6 minute-walk distance (6MWD) after 12 weeks of rehabilitation.Results: All patients in the NPV-exercise group were able to tolerate and completed the program. The between-group differences were significantly better in the NPV-exercise group in changes of 6MWD (34.1 ± 12.7 m vs. -32.5 ± 17.5 m; P = 0.011) and St George Score (-14.5 ± 3.6 vs. 11.8 ± 6.0; P <0.01). There was an improvement in dyspnea sensation (Borg's scale, from 1.4 ± 1.5 point to 0.8 ± 1.3 point, P = 0.049) and a small increase in FVC (from 0.85 ± 0.09 L to 0.91 ± 0.08 L, P = 0.029) in the NPV-exercise group compared to the control group.Conclusion: Exercise training with NPV support is feasible for patients with severe restrictive lung diseases, and improves exercise capacity and health-related quality of life.

AB - Background: Exercise training is of benefit for patients with restrictive lung disease. However, it tends to be intolerable for those with severe disease. We examined whether providing ventilatory assistance by using negative pressure ventilators (NPV) during exercise training is feasible for such patients and the effects of training.Methods: 36 patients with restrictive lung disease were prospectively enrolled for a 12-week multidisciplinary rehabilitation program. During this program, half of them (n:18; 60.3 ± 11.6 years; 6 men; FVC: 32.5 ± 11.7% predicted ) received regular sessions of exercise training under NPV, whilst the 18 others (59.6 ± 12.3 years; 8 men; FVC: 37.7 ± 10.2% predicted) did not. Exercise capacity, pulmonary function, dyspnea and quality of life were measured. The primary endpoint was the between-group difference in change of 6 minute-walk distance (6MWD) after 12 weeks of rehabilitation.Results: All patients in the NPV-exercise group were able to tolerate and completed the program. The between-group differences were significantly better in the NPV-exercise group in changes of 6MWD (34.1 ± 12.7 m vs. -32.5 ± 17.5 m; P = 0.011) and St George Score (-14.5 ± 3.6 vs. 11.8 ± 6.0; P <0.01). There was an improvement in dyspnea sensation (Borg's scale, from 1.4 ± 1.5 point to 0.8 ± 1.3 point, P = 0.049) and a small increase in FVC (from 0.85 ± 0.09 L to 0.91 ± 0.08 L, P = 0.029) in the NPV-exercise group compared to the control group.Conclusion: Exercise training with NPV support is feasible for patients with severe restrictive lung diseases, and improves exercise capacity and health-related quality of life.

KW - Exercise capacity

KW - Exercise training

KW - Health-related quality of life

KW - Negative pressure ventilation

KW - Restrictive lung disease

UR - http://www.scopus.com/inward/record.url?scp=84873954895&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84873954895&partnerID=8YFLogxK

U2 - 10.1186/1465-9921-14-22

DO - 10.1186/1465-9921-14-22

M3 - Article

C2 - 23421438

AN - SCOPUS:84873954895

VL - 14

JO - Respiratory Research

JF - Respiratory Research

SN - 1465-9921

IS - 1

M1 - 22

ER -