Exercise training with negative pressure ventilation improves exercise capacity in patients with severe restrictive lung disease: A prospective controlled study

Shu Chuan Ho, Horng Chyuan Lin, Han Pin Kuo, Li Fei Chen, Te Fang Sheng, Wen Ching Jao, Chun Hua Wang, Kang Yun Lee

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5 Citations (Scopus)


Background: Exercise training is of benefit for patients with restrictive lung disease. However, it tends to be intolerable for those with severe disease. We examined whether providing ventilatory assistance by using negative pressure ventilators (NPV) during exercise training is feasible for such patients and the effects of training.Methods: 36 patients with restrictive lung disease were prospectively enrolled for a 12-week multidisciplinary rehabilitation program. During this program, half of them (n:18; 60.3 ± 11.6 years; 6 men; FVC: 32.5 ± 11.7% predicted ) received regular sessions of exercise training under NPV, whilst the 18 others (59.6 ± 12.3 years; 8 men; FVC: 37.7 ± 10.2% predicted) did not. Exercise capacity, pulmonary function, dyspnea and quality of life were measured. The primary endpoint was the between-group difference in change of 6 minute-walk distance (6MWD) after 12 weeks of rehabilitation.Results: All patients in the NPV-exercise group were able to tolerate and completed the program. The between-group differences were significantly better in the NPV-exercise group in changes of 6MWD (34.1 ± 12.7 m vs. -32.5 ± 17.5 m; P = 0.011) and St George Score (-14.5 ± 3.6 vs. 11.8 ± 6.0; P <0.01). There was an improvement in dyspnea sensation (Borg's scale, from 1.4 ± 1.5 point to 0.8 ± 1.3 point, P = 0.049) and a small increase in FVC (from 0.85 ± 0.09 L to 0.91 ± 0.08 L, P = 0.029) in the NPV-exercise group compared to the control group.Conclusion: Exercise training with NPV support is feasible for patients with severe restrictive lung diseases, and improves exercise capacity and health-related quality of life.

Original languageEnglish
Article number22
JournalRespiratory Research
Issue number1
Publication statusPublished - Feb 19 2013
Externally publishedYes



  • Exercise capacity
  • Exercise training
  • Health-related quality of life
  • Negative pressure ventilation
  • Restrictive lung disease

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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