Evolutional change of karyotype with t(8;9)(p22;p24) and HLA-DR immunophenotype in relapsed acute myeloid leukemia

Kuan Po Huang, Andrew J. Chase, Nicholas C.P. Cross, Andrea Reiter, Tzu Ying Li, Tso Fu Wang, Sung Chao Chu, Xuan Yin Lu, Chi Cheng Li, Ruey Ho Kao

Research output: Contribution to journalArticle

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Abstract

The rare recurrent translocation of (8;9)(p22;p24) with PCM1-JAK2 fusion was recently characterized in diverse hematological malignancies. Most of them are atypical chronic myeloid leukemia (CML) or other myeloproliferative disorders (MPD), and are predominantly in the male. We report a female patient with acute myeloid leukemia (AML) initially presenting with normal karyotype and negative HLA-DR expression who achieved complete remission after standard chemotherapy. The disease relapsed 7 months later with cytogenetic change of t(8;9)(p22;p24). Flow cytometry analysis showed evolutional change of immunophenotype from negative to positive HLA-DR expression and fluorescence in situ hybridization (FISH) analysis demonstrated a PCM1-JAK2 fusion gene. We speculate that the cytogenetic change of t(8;9)(p22;p24) may induce HLA-DR immunophenotypic switch and a coordination of the two evolutional changes may play a role in leukemic cell progression.

Original languageEnglish
Pages (from-to)197-201
Number of pages5
JournalInternational Journal of Hematology
Volume88
Issue number2
DOIs
Publication statusPublished - Sep 1 2008
Externally publishedYes

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HLA-DR Antigens
Karyotype
Acute Myeloid Leukemia
Cytogenetics
Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative
Myeloproliferative Disorders
Gene Fusion
Hematologic Neoplasms
Fluorescence In Situ Hybridization
Flow Cytometry
Drug Therapy

Keywords

  • Acute myeloid leukemia
  • Chromosome 8
  • Chromosome 9
  • Translocation

ASJC Scopus subject areas

  • Hematology

Cite this

Evolutional change of karyotype with t(8;9)(p22;p24) and HLA-DR immunophenotype in relapsed acute myeloid leukemia. / Huang, Kuan Po; Chase, Andrew J.; Cross, Nicholas C.P.; Reiter, Andrea; Li, Tzu Ying; Wang, Tso Fu; Chu, Sung Chao; Lu, Xuan Yin; Li, Chi Cheng; Kao, Ruey Ho.

In: International Journal of Hematology, Vol. 88, No. 2, 01.09.2008, p. 197-201.

Research output: Contribution to journalArticle

Huang, Kuan Po ; Chase, Andrew J. ; Cross, Nicholas C.P. ; Reiter, Andrea ; Li, Tzu Ying ; Wang, Tso Fu ; Chu, Sung Chao ; Lu, Xuan Yin ; Li, Chi Cheng ; Kao, Ruey Ho. / Evolutional change of karyotype with t(8;9)(p22;p24) and HLA-DR immunophenotype in relapsed acute myeloid leukemia. In: International Journal of Hematology. 2008 ; Vol. 88, No. 2. pp. 197-201.
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