Evolution of left atrial systolic and diastolic functions in different stages of hypertension

Distinct effects of blood pressure control

Chia Ti Tsai, Juey Jen Hwang, Yi Chung Shih, Fu Tien Chiang, Ling Ping Lai, Jiunn Lee Lin

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: To evaluate the left atrial (LA) volume, and LA systolic (contractile) and diastolic (expansion) functions in different stages of hypertension with or without atrial fibrillation (AF), as well as the effects of good blood pressure control. Methods: A prospective observational study. Individuals including 22 normotensive controls, 23 patients with mild hypertension, 20 with severe hypertension, and 17 with hypertension and paroxysmal AF were recruited for paired echocardiography studies at baseline and 6 months after control of hypertension. Results: With increasing severity of hypertension, left ventricular (LV) diastolic function deteriorated with decreasing LV septal E′/A′ and increasing E/E′ ratios. LA expansion index was reduced in parallel. LA expansion index was correlated positively with LV E′/A′ (r = 0.43, p = 0.022) and inversely with LV E/E′ (r = 0.49, p = 0.009). Significant improvement of LV diastolic function and LA expansion index preceded the reduction of LA volume after blood pressure control. In patients with paroxysmal AF, LA volume reduction was more evident in patients receiving angiotensin-converting enzyme inhibitors or angiotensin II type 1 receptor blockers. Conclusions: With progressive LV diastolic dysfunction in hypertension, there was a corresponding deterioration in LA diastolic function. Effective blood pressure control for 6 months improved LA diastolic function.

Original languageEnglish
Pages (from-to)180-187
Number of pages8
JournalCardiology
Volume109
Issue number3
DOIs
Publication statusPublished - Feb 1 2008
Externally publishedYes

Fingerprint

Blood Pressure
Hypertension
Left Atrial Function
Atrial Fibrillation
Left Ventricular Function
Angiotensin II Type 1 Receptor Blockers
Left Ventricular Dysfunction
Angiotensin-Converting Enzyme Inhibitors
Observational Studies
Echocardiography
Prospective Studies

Keywords

  • Diastolic dysfunction
  • Echocardiography
  • Hypertension
  • Left atrial functions
  • Left atrial volume

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Evolution of left atrial systolic and diastolic functions in different stages of hypertension : Distinct effects of blood pressure control. / Tsai, Chia Ti; Hwang, Juey Jen; Shih, Yi Chung; Chiang, Fu Tien; Lai, Ling Ping; Lin, Jiunn Lee.

In: Cardiology, Vol. 109, No. 3, 01.02.2008, p. 180-187.

Research output: Contribution to journalArticle

Tsai, Chia Ti ; Hwang, Juey Jen ; Shih, Yi Chung ; Chiang, Fu Tien ; Lai, Ling Ping ; Lin, Jiunn Lee. / Evolution of left atrial systolic and diastolic functions in different stages of hypertension : Distinct effects of blood pressure control. In: Cardiology. 2008 ; Vol. 109, No. 3. pp. 180-187.
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