Evolution of alu family repeats since the divergence of human and chimpanzee

Ikuhisa Sawada, Cary Willard, Che Kun James Shen, Barbara Chapman, Allan C. Wilson, Carl W. Schmid

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

The DNA sequences of three members of the Alu family of repeated sequences located 5′ to the chimpanzee α2 gene have been determined. The base sequences of the three corresponding human Alu family repeats have been previously determined, permitting the comparison of identical Alu family members in human and chimpanzee. Here we compare the sequences of seven pairs of chimpanzee and human Alu repeats. In each case, with the exception of minor sequence differences, the identical Alu repeat is located at identical sites in the human and chimpanzee genomes. The Alu repeats diverge at the rate expected for nonselected sequences. Sequence conversion has not replaced any of these 14 Alu family members since the divergence between chimpanzee and human.

Original languageEnglish
Pages (from-to)316-322
Number of pages7
JournalJournal of Molecular Evolution
Volume22
Issue number4
DOIs
Publication statusPublished - Dec 1985
Externally publishedYes

Keywords

  • Alu repeats
  • Primate evolution

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics

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