Evidence for the involvement of dopamine D1 and D2 receptors in mediating the decrease of food intake during repeated treatment with amphetamine

T. Y. Chen, S. L. Duh, C. C. Huang, T. B. Lin, D. Y. Kuo

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Repeated treatment with amphetamine (AMPH), a well-known anorectic agent, into animals could induce anorexia on day 1 and produce a gradual reversion of food intake (tolerant anorexia) on the following days. It is unknown whether these feeding changes are related to dopamine (DA) and/or noradrenergic neurotransmission. Thus, the present study investigated the subtype of receptor mediating AMPH-induced anorexia. Daily food intake was measured after various drugs were given. Pretreatment with haloperidol, an antagonist of DA receptors, may lead to inhibition of AMPH-induced anorexia. However, pretreatment with the α-adrenoceptor antagonist phentolamine, and the β-adrenoceptor antagonist propranolol, failed to modify the action of AMPH, suggesting the involvement of DA receptors but not adrenoceptors in the action of AMPH-induced anorexia. Furthermore, pretreatment with SCH 23390 at a dose sufficient to block D1 receptors or pimozide at a dose sufficient to inhibit D2 receptors blocked AMPH-induced anorexia, indicating the involvement of D1 and D2 receptors. In a study of tolerant anorexia, repeated treatment with the D1/D2 agonist apomorphine, but not the D1 agonist SKF 38393 or D2 agonist quinpirole, induced an AMPH-like tolerant feeding response, providing evidence for conjoint action of D1 and D2 receptors in the effect. The present results suggest that both D1 and D2 receptors are involved in anorexia and tolerant anorexia induced by chronic intermittent administration of AMPH.

Original languageEnglish
Pages (from-to)462-466
Number of pages5
JournalJournal of Biomedical Science
Volume8
Issue number6
DOIs
Publication statusPublished - 2001
Externally publishedYes

Fingerprint

Dopamine D1 Receptors
Dopamine D2 Receptors
Anorexia
Amphetamine
Eating
Adrenergic Receptors
2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine
Pimozide
Quinpirole
Appetite Depressants
Dopamine Antagonists
Apomorphine
Phentolamine
Dopamine Receptors
Haloperidol
Propranolol
Synaptic Transmission
Dopamine
Animals

Keywords

  • Amphetamine
  • Dopamine receptor
  • Food intake
  • Pimozide
  • Quinpirole
  • SCH 23390
  • SKF 38393

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Evidence for the involvement of dopamine D1 and D2 receptors in mediating the decrease of food intake during repeated treatment with amphetamine. / Chen, T. Y.; Duh, S. L.; Huang, C. C.; Lin, T. B.; Kuo, D. Y.

In: Journal of Biomedical Science, Vol. 8, No. 6, 2001, p. 462-466.

Research output: Contribution to journalArticle

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