Everyday cognition scales are related to cognitive function in the early stage of probable Alzheimer's disease and FDG-PET findings

Jung Lung Hsu, Wen Chuin Hsu, Chiung Chih Chang, Kun Ju Lin, Ing Tsung Hsiao, Yen Chun Fan, Chyi Huey Bai

Research output: Contribution to journalArticle

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Abstract

We applied the Everyday Cognition (ECog) scale in normal aging adults and patients with Alzheimer's disease (AD) to investigate associations between neuropsychological tests and neuroimaging markers. A total of 160 normal aging adults and 40 patients with the early stage of probable AD were included. Neuropsychological performance was assessed using the Consortium to Establish a Registry for Alzheimer's Disease Neuropsychological Assessment Battery (CERAD-NAB). 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) scans were used to measure AD-related hypometabolism. Nonparametric Spearman correlation analysis was used to study associations between ECog and z-transformed total CERAD-NAB scores in both groups. The results revealed a significant correlation between total ECog and CERAD-NAB scores (rho = -0.28, p < 0.01), and category verbal fluency test with the executive domain of the ECog scale (rho = -0.20, p < 0.01). The CERAD-NAB scores were also significantly correlated with AD-related hypometabolism (rho = -0.49, p < 0.01). The memory domain of the ECog scale was significantly correlated with FDG uptake in the angular gyrus and posterior cingulum gyrus (rho = -0.41 and -0.46, P < 0.01). In conclusion, both total and memory domain ECog scores were correlated with the neuropsychological tests and neuroimaging biomarkers.

Original languageEnglish
Article number1719
JournalScientific Reports
Volume7
Issue number1
DOIs
Publication statusPublished - Dec 1 2017

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Positron-Emission Tomography
Cognition
Alzheimer Disease
Registries
Neuropsychological Tests
Neuroimaging
Parietal Lobe
Fluorodeoxyglucose F18
Biomarkers

ASJC Scopus subject areas

  • General

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Everyday cognition scales are related to cognitive function in the early stage of probable Alzheimer's disease and FDG-PET findings. / Hsu, Jung Lung; Hsu, Wen Chuin; Chang, Chiung Chih; Lin, Kun Ju; Hsiao, Ing Tsung; Fan, Yen Chun; Bai, Chyi Huey.

In: Scientific Reports, Vol. 7, No. 1, 1719, 01.12.2017.

Research output: Contribution to journalArticle

Hsu, Jung Lung ; Hsu, Wen Chuin ; Chang, Chiung Chih ; Lin, Kun Ju ; Hsiao, Ing Tsung ; Fan, Yen Chun ; Bai, Chyi Huey. / Everyday cognition scales are related to cognitive function in the early stage of probable Alzheimer's disease and FDG-PET findings. In: Scientific Reports. 2017 ; Vol. 7, No. 1.
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