Evaluation of the role of H pylori infection in pathogenesis of gastric cancer by immunoblot assay

Kuo Ching Yang; Alexander Chu; Chao Sheng Liao; Yu Min Lin; Gen Min Wang

doi:10.3748/wjg.v12.i43.7029

Evaluation of the role of H pylori infection in pathogenesis of gastric cancer by immunoblot assay

Kuo Ching Yang, Alexander Chu, Chao Sheng Liao, Yu Min Lin, Gen Min Wang

Taipei Medical University

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Aim: To elucidate the different serological reactions to H pylori using the immunoblotting technique for further understanding of its pathogenic role in gastric cancer. Methods: A total of 54 patients were divided into two groups after upper gastrointestinal endoscopy: normal control group (25 patients) and gastric cancer group (29 patients). Both groups were further divided into H pylori (+) and H pylori (-) subgroups based on the results of CLO test, Giemsa staining and culture. Sera were further analyzed with the immunoblotting technique (HelicoBlot 2.0, Genelabs Diagnostics, Singapore). Results: The positive rate of the immunoblotting test was as high as 88.9% in the H pylori (-) gastric cancer group and only 14.3% in the H pylori (-) normal control group with a statistically significant difference. Conclusion: The prevalence of H pylori infection is higher in gastric cancer patients than in the normal controls, suggesting that H pylori may play a role in the pathogenesis of gastric cancer.

Original language	English
Pages (from-to)	7029-7032
Number of pages	4
Journal	World Journal of Gastroenterology
Volume	12
Issue number	43
DOIs	https://doi.org/10.3748/wjg.v12.i43.7029
Publication status	Published - Nov 21 2006

Keywords

Enzyme-linked immunosorbent assay
Gastric cancer
H pylori
Immunoblotting
Western blot

ASJC Scopus subject areas

Gastroenterology

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title = "Evaluation of the role of H pylori infection in pathogenesis of gastric cancer by immunoblot assay",

abstract = "Aim: To elucidate the different serological reactions to H pylori using the immunoblotting technique for further understanding of its pathogenic role in gastric cancer. Methods: A total of 54 patients were divided into two groups after upper gastrointestinal endoscopy: normal control group (25 patients) and gastric cancer group (29 patients). Both groups were further divided into H pylori (+) and H pylori (-) subgroups based on the results of CLO test, Giemsa staining and culture. Sera were further analyzed with the immunoblotting technique (HelicoBlot 2.0, Genelabs Diagnostics, Singapore). Results: The positive rate of the immunoblotting test was as high as 88.9% in the H pylori (-) gastric cancer group and only 14.3% in the H pylori (-) normal control group with a statistically significant difference. Conclusion: The prevalence of H pylori infection is higher in gastric cancer patients than in the normal controls, suggesting that H pylori may play a role in the pathogenesis of gastric cancer.",

keywords = "Enzyme-linked immunosorbent assay, Gastric cancer, H pylori, Immunoblotting, Western blot",

author = "Yang, {Kuo Ching} and Alexander Chu and Liao, {Chao Sheng} and Lin, {Yu Min} and Wang, {Gen Min}",

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doi = "10.3748/wjg.v12.i43.7029",

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T1 - Evaluation of the role of H pylori infection in pathogenesis of gastric cancer by immunoblot assay

AU - Yang, Kuo Ching

AU - Chu, Alexander

AU - Liao, Chao Sheng

AU - Lin, Yu Min

AU - Wang, Gen Min

PY - 2006/11/21

Y1 - 2006/11/21

N2 - Aim: To elucidate the different serological reactions to H pylori using the immunoblotting technique for further understanding of its pathogenic role in gastric cancer. Methods: A total of 54 patients were divided into two groups after upper gastrointestinal endoscopy: normal control group (25 patients) and gastric cancer group (29 patients). Both groups were further divided into H pylori (+) and H pylori (-) subgroups based on the results of CLO test, Giemsa staining and culture. Sera were further analyzed with the immunoblotting technique (HelicoBlot 2.0, Genelabs Diagnostics, Singapore). Results: The positive rate of the immunoblotting test was as high as 88.9% in the H pylori (-) gastric cancer group and only 14.3% in the H pylori (-) normal control group with a statistically significant difference. Conclusion: The prevalence of H pylori infection is higher in gastric cancer patients than in the normal controls, suggesting that H pylori may play a role in the pathogenesis of gastric cancer.

AB - Aim: To elucidate the different serological reactions to H pylori using the immunoblotting technique for further understanding of its pathogenic role in gastric cancer. Methods: A total of 54 patients were divided into two groups after upper gastrointestinal endoscopy: normal control group (25 patients) and gastric cancer group (29 patients). Both groups were further divided into H pylori (+) and H pylori (-) subgroups based on the results of CLO test, Giemsa staining and culture. Sera were further analyzed with the immunoblotting technique (HelicoBlot 2.0, Genelabs Diagnostics, Singapore). Results: The positive rate of the immunoblotting test was as high as 88.9% in the H pylori (-) gastric cancer group and only 14.3% in the H pylori (-) normal control group with a statistically significant difference. Conclusion: The prevalence of H pylori infection is higher in gastric cancer patients than in the normal controls, suggesting that H pylori may play a role in the pathogenesis of gastric cancer.

KW - Enzyme-linked immunosorbent assay

KW - Gastric cancer

KW - H pylori

KW - Immunoblotting

KW - Western blot

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Evaluation of the role of H pylori infection in pathogenesis of gastric cancer by immunoblot assay

Abstract

Keywords

ASJC Scopus subject areas

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