Evaluation of the hepatic and renal-protective effects of ganoderma lucidum in mice

Ying Hua Shieh; Chi Feng Liu; Yao Kuan Huang; Jen Yuann Yang; I. Lin Wu; Chia Hsien Lin; Song-Chow Lin

doi:10.1142/s0192415x01000526

Evaluation of the hepatic and renal-protective effects of ganoderma lucidum in mice

Ying Hua Shieh, Chi Feng Liu, Yao Kuan Huang, Jen Yuann Yang, I. Lin Wu, Chia Hsien Lin, Song-Chow Lin

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46 Citations (Scopus)

Abstract

The antioxidative effect of hot water extract of the mushroom Ganodcrma lucidum on ethanol-induced free radical generation had been studied. In order to further investigate the hepatic and renal protective mechanism of Ganoderma lucidum, rates of lipid peroxidation were determined. The hot water extract of Ganoderma lucidum dose-dependently exhibited antioxidative effect on mouse liver and kidney lipid peroxidation; our results indicated that hepatic and renal homogenates have a higher malonic dialdehyde level in an ethanol administered group than in the Ganoderma lucidum treated group. It was concluded that the hepatic and renal protective mechanism of Ganoderma lucidum, might be due at least in part to its prominent Superoxide scavenging effect. Ganoderma extract could protect the liver and kidney from Superoxide induced hepatic and renal damages.

Original language	English
Pages (from-to)	501-507
Number of pages	7
Journal	American Journal of Chinese Medicine
Volume	29
Issue number	3-4
DOIs	https://doi.org/10.1142/s0192415x01000526
Publication status	Published - 2001

ASJC Scopus subject areas

Complementary and alternative medicine

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title = "Evaluation of the hepatic and renal-protective effects of ganoderma lucidum in mice",

abstract = "The antioxidative effect of hot water extract of the mushroom Ganodcrma lucidum on ethanol-induced free radical generation had been studied. In order to further investigate the hepatic and renal protective mechanism of Ganoderma lucidum, rates of lipid peroxidation were determined. The hot water extract of Ganoderma lucidum dose-dependently exhibited antioxidative effect on mouse liver and kidney lipid peroxidation; our results indicated that hepatic and renal homogenates have a higher malonic dialdehyde level in an ethanol administered group than in the Ganoderma lucidum treated group. It was concluded that the hepatic and renal protective mechanism of Ganoderma lucidum, might be due at least in part to its prominent Superoxide scavenging effect. Ganoderma extract could protect the liver and kidney from Superoxide induced hepatic and renal damages.",

author = "Shieh, {Ying Hua} and Liu, {Chi Feng} and Huang, {Yao Kuan} and Yang, {Jen Yuann} and Wu, {I. Lin} and Lin, {Chia Hsien} and Song-Chow Lin",

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T1 - Evaluation of the hepatic and renal-protective effects of ganoderma lucidum in mice

AU - Shieh, Ying Hua

AU - Liu, Chi Feng

AU - Huang, Yao Kuan

AU - Yang, Jen Yuann

AU - Wu, I. Lin

AU - Lin, Chia Hsien

AU - Lin, Song-Chow

PY - 2001

Y1 - 2001

N2 - The antioxidative effect of hot water extract of the mushroom Ganodcrma lucidum on ethanol-induced free radical generation had been studied. In order to further investigate the hepatic and renal protective mechanism of Ganoderma lucidum, rates of lipid peroxidation were determined. The hot water extract of Ganoderma lucidum dose-dependently exhibited antioxidative effect on mouse liver and kidney lipid peroxidation; our results indicated that hepatic and renal homogenates have a higher malonic dialdehyde level in an ethanol administered group than in the Ganoderma lucidum treated group. It was concluded that the hepatic and renal protective mechanism of Ganoderma lucidum, might be due at least in part to its prominent Superoxide scavenging effect. Ganoderma extract could protect the liver and kidney from Superoxide induced hepatic and renal damages.

AB - The antioxidative effect of hot water extract of the mushroom Ganodcrma lucidum on ethanol-induced free radical generation had been studied. In order to further investigate the hepatic and renal protective mechanism of Ganoderma lucidum, rates of lipid peroxidation were determined. The hot water extract of Ganoderma lucidum dose-dependently exhibited antioxidative effect on mouse liver and kidney lipid peroxidation; our results indicated that hepatic and renal homogenates have a higher malonic dialdehyde level in an ethanol administered group than in the Ganoderma lucidum treated group. It was concluded that the hepatic and renal protective mechanism of Ganoderma lucidum, might be due at least in part to its prominent Superoxide scavenging effect. Ganoderma extract could protect the liver and kidney from Superoxide induced hepatic and renal damages.

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Evaluation of the hepatic and renal-protective effects of ganoderma lucidum in mice

Abstract

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