Evaluation of the antihyperuricemic activity of phytochemicals from Davallia formosana by enzyme assay and hyperuricemic mice model

Chen Yu Chen, Chi Chang Huang, Keng Chang Tsai, Wei Jan Huang, Wen Ching Huang, Yu Chen Hsu, Feng-Lin Hsu

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Abnormal serum urate levels are recognized as a critical factor in the progression of several chronic diseases. To evaluate the antihyperuricemic effect of Davallia formosana, the inhibitory activities of 15 isolated phytochemicals, including five novel compounds of 6,8-dihydroxychromone-7-C- β-d-glucopyranoside (1), 6,8,3′,4′-tetrahydroxyflavanone-7-C- β-d-glucopyranoside (2), 6,8,4′-trihydroxyflavanone-7-C-β-d- glucopyranoside (3), 8-(2-pyrrolidinone-5-yl)-catechin-3-O-β-d- allopyranoside (4), and epiphyllocoumarin-3-O-β-d-allopyranoside (5), were examined against xanthine oxidase (XOD) and in a potassium oxonate-(PTO-) induced acute hyperuricemic mice model. The results indicated that compounds 3 and 5 significantly inhibited XOD activity in vitro and reduced serum uric acid levels in vivo. This is the first report providing new insights into the antihyperuricemic activities of flavonoid glycosides which can possibly be developed into potential hypouricemic agents.

Original languageEnglish
Article number873607
JournalEvidence-based Complementary and Alternative Medicine
Volume2014
DOIs
Publication statusPublished - 2014

ASJC Scopus subject areas

  • Complementary and alternative medicine

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