Evaluation of the activity of tartrate-resistant acid phosphatase isoform 5b in normal Chinese children - A novel marker for bone growth

Chun Jung Chen, Tsu Yi Chao, Anthony J. Janckila, Shin Nan Cheng, Chih Hung Ku, Der Ming Chu

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background: Most parents are very concerned about the height of their children. Biochemical markers of bone formation and resorption may provide useful clinical predictors for bone growth. Tartrate-resistant acid phosphatase 5b (TRAcP 5b) has been advocated as a biomarker of osteoclast activity and bone resorption. However, the TRAcP 5b levels of children at different ages are still unknown. It is necessary to accumulate and analyze the data for healthy children at different ages. Objectives: We use an improved immunoassay for bone TRAcP 5b to examine sera from children to see whether it is a significant marker of bone growth. Methods: Serum, including cord blood, was collected from 404 normal (Chinese children (age range 0-17 years; 225 male, 179 female). The venous blood was withdrawn from the peripheral vein and stored at 4°C before centrifugation for serum collection. All sera were stored at -70°C and thawed at 37°C immediately before TRAcP 5b levels were measured. Bone-specific alkaline phosphatase (BAP) was also used for comparison with TRAcP 5b levels at different ages. Results: TRAcP 5b levels were extremely high in infants of both genders, gradually decreasing with age (p

Original languageEnglish
Pages (from-to)55-62
Number of pages8
JournalJournal of Pediatric Endocrinology and Metabolism
Volume18
Issue number1
Publication statusPublished - Jan 2005
Externally publishedYes

Keywords

  • Bone markers
  • Bone-Specific alkaline phosphatase
  • Tartrate-resistant acid phosphatase 5b

ASJC Scopus subject areas

  • Endocrinology
  • Pediatrics, Perinatology, and Child Health

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