Evaluation of Nitroglycerin Premedication on the Arterial Luminal Diameter and Branches of Coronary Arteries on 64-Multidetector Computed Tomography Angiography

Chi-Ming Lee, Hung Jung Wang, Ching Huei Kung, Yi Hsiang Lin, Ting-Kai Leung, Chun-Yao Huang, Chun-Ming Shih, Wen Tien Hsiao, Ya Yen Chen

Research output: Contribution to journalArticle

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Abstract

Background: The 64-multidetector computed tomography (64-MDCT) has developed into a mature clinical tool to detect coronary artery disease. This 64-MDCT system permits cross-sectional and longitudinal imaging of the coronary arteries with a high spatial and temporal resolution. However, small vessels, side branches and the distal portions of the main coronary arteries are not always optimally visualized. Purpose: The aim of this study was to evaluate the effect of nitroglycerin (NTG) on lumen diameters and the number of visualized side branches of the coronary arteries on 64-MDCT. We also assessed whether NTG would affect the quality of the images of the coronary arteries obtained by 64-MDCT. Methods: Sixty-seven patients were randomized and divided into two groups: Group C (31 patients, no sublingual NTG) and Group N (36 patients, sublingual NTG given before the scan). We measured the lumen diameter of the coronary artery and visibility of the side branches by using the 64-MDCT system and also evaluated the image quality by using the scores. Results: The cardiac 64-MDCT images of these patients showed that the average diameters of the proximal segments in the right coronary artery, left main artery, left anterior descending coronary artery, and left circumflex coronary artery were 4.1 ± 0.7. mm, 3.9 ± 0.6. mm, 3.6 ± 0.7. mm, and 3.4 ± 0.6. mm, respectively, in Group N and 3.0 ± 0.5. mm, 3.1 ± 0.6. mm, 2.8 ± 0.5. mm, and 2.7 ± 0.5. mm, respectively in Group C. In addition, the scores for visibility and image quality for the side branches in Group N were significant higher than for those in Group C. Conclusion: Our study indicates that CT coronary angiography using 64-MDCT with NTG administration produces images of diagnostically acceptable quality in all coronary segments. Thus, NTG might be recommended for routine 64-MDCT coronary angiography examinations.

Original languageEnglish
Pages (from-to)85-88
Number of pages4
JournalJournal of Experimental and Clinical Medicine(Taiwan)
Volume3
Issue number2
DOIs
Publication statusPublished - Apr 2011

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Multidetector Computed Tomography
Premedication
Nitroglycerin
Coronary Vessels
Coronary Angiography
Computed Tomography Angiography
Coronary Artery Disease
Arteries

Keywords

  • 64-MDCT
  • Coronary angiography
  • Nitroglycerin

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Evaluation of Nitroglycerin Premedication on the Arterial Luminal Diameter and Branches of Coronary Arteries on 64-Multidetector Computed Tomography Angiography. / Lee, Chi-Ming; Wang, Hung Jung; Kung, Ching Huei; Lin, Yi Hsiang; Leung, Ting-Kai; Huang, Chun-Yao; Shih, Chun-Ming; Hsiao, Wen Tien; Chen, Ya Yen.

In: Journal of Experimental and Clinical Medicine(Taiwan), Vol. 3, No. 2, 04.2011, p. 85-88.

Research output: Contribution to journalArticle

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abstract = "Background: The 64-multidetector computed tomography (64-MDCT) has developed into a mature clinical tool to detect coronary artery disease. This 64-MDCT system permits cross-sectional and longitudinal imaging of the coronary arteries with a high spatial and temporal resolution. However, small vessels, side branches and the distal portions of the main coronary arteries are not always optimally visualized. Purpose: The aim of this study was to evaluate the effect of nitroglycerin (NTG) on lumen diameters and the number of visualized side branches of the coronary arteries on 64-MDCT. We also assessed whether NTG would affect the quality of the images of the coronary arteries obtained by 64-MDCT. Methods: Sixty-seven patients were randomized and divided into two groups: Group C (31 patients, no sublingual NTG) and Group N (36 patients, sublingual NTG given before the scan). We measured the lumen diameter of the coronary artery and visibility of the side branches by using the 64-MDCT system and also evaluated the image quality by using the scores. Results: The cardiac 64-MDCT images of these patients showed that the average diameters of the proximal segments in the right coronary artery, left main artery, left anterior descending coronary artery, and left circumflex coronary artery were 4.1 ± 0.7. mm, 3.9 ± 0.6. mm, 3.6 ± 0.7. mm, and 3.4 ± 0.6. mm, respectively, in Group N and 3.0 ± 0.5. mm, 3.1 ± 0.6. mm, 2.8 ± 0.5. mm, and 2.7 ± 0.5. mm, respectively in Group C. In addition, the scores for visibility and image quality for the side branches in Group N were significant higher than for those in Group C. Conclusion: Our study indicates that CT coronary angiography using 64-MDCT with NTG administration produces images of diagnostically acceptable quality in all coronary segments. Thus, NTG might be recommended for routine 64-MDCT coronary angiography examinations.",
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AU - Lee, Chi-Ming

AU - Wang, Hung Jung

AU - Kung, Ching Huei

AU - Lin, Yi Hsiang

AU - Leung, Ting-Kai

AU - Huang, Chun-Yao

AU - Shih, Chun-Ming

AU - Hsiao, Wen Tien

AU - Chen, Ya Yen

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AB - Background: The 64-multidetector computed tomography (64-MDCT) has developed into a mature clinical tool to detect coronary artery disease. This 64-MDCT system permits cross-sectional and longitudinal imaging of the coronary arteries with a high spatial and temporal resolution. However, small vessels, side branches and the distal portions of the main coronary arteries are not always optimally visualized. Purpose: The aim of this study was to evaluate the effect of nitroglycerin (NTG) on lumen diameters and the number of visualized side branches of the coronary arteries on 64-MDCT. We also assessed whether NTG would affect the quality of the images of the coronary arteries obtained by 64-MDCT. Methods: Sixty-seven patients were randomized and divided into two groups: Group C (31 patients, no sublingual NTG) and Group N (36 patients, sublingual NTG given before the scan). We measured the lumen diameter of the coronary artery and visibility of the side branches by using the 64-MDCT system and also evaluated the image quality by using the scores. Results: The cardiac 64-MDCT images of these patients showed that the average diameters of the proximal segments in the right coronary artery, left main artery, left anterior descending coronary artery, and left circumflex coronary artery were 4.1 ± 0.7. mm, 3.9 ± 0.6. mm, 3.6 ± 0.7. mm, and 3.4 ± 0.6. mm, respectively, in Group N and 3.0 ± 0.5. mm, 3.1 ± 0.6. mm, 2.8 ± 0.5. mm, and 2.7 ± 0.5. mm, respectively in Group C. In addition, the scores for visibility and image quality for the side branches in Group N were significant higher than for those in Group C. Conclusion: Our study indicates that CT coronary angiography using 64-MDCT with NTG administration produces images of diagnostically acceptable quality in all coronary segments. Thus, NTG might be recommended for routine 64-MDCT coronary angiography examinations.

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