Abstract

We studied the effects of multi- and single-target liposomal drugs on human gastric cancer cell AGS both in vitro and in vivo. The cytotoxic effect of dihydrotanshinone I was significantly enhanced by treatment with octreotide-polyethylene glycol(PEG)-liposome, Arg-Gly-Asp(RGD)-PEG-liposome, and RGD/octreotide-PEG-liposome encapsulated with 0.5 μg/ml of dihydrotanshinone I to AGS cell for 24 h, compared to control. Furthermore, the AGS cell survival rate for multi-target versus single target liposomal drugs was significantly suppressed. Microsocpic examination revealed that significant cell death occurred in the multi- and single-target liposomal encapsulated drug groups. Significant suppression of tumor growth in AGS cell xenograft nude mice given octreotide-PEG-liposome, RGD/octreotide-PEG-liposome encapsulated drug, versus those given a free drug was noted after 13 d of experimentation with the multi-targeted liposome: up to 60.75% and 41.2% reduction of tumor volume as compared to dimethylsulfoxide (DMSO) control and the free drug groups respectively. The treated animals showed no gross signs of toxicity. The results have potential clinical application.

Original languageEnglish
Pages (from-to)1586-1594
Number of pages9
JournalBioscience, Biotechnology and Biochemistry
Volume72
Issue number6
DOIs
Publication statusPublished - 2008

Fingerprint

stomach neoplasms
Liposomes
octreotide
drug therapy
Stomach Neoplasms
polyethylene glycol
Octreotide
Polyethylene glycols
drugs
Pharmaceutical Preparations
Tumors
Therapeutics
Cells
neoplasms
Drug and Narcotic Control
Cell death
dimethyl sulfoxide
Dimethyl Sulfoxide
Tumor Burden
Heterografts

Keywords

  • Arg-Gly-Asp (RGD)
  • Gastric cancer
  • Liposome
  • Octreotide
  • Xenograft

ASJC Scopus subject areas

  • Bioengineering
  • Biotechnology
  • Biochemistry
  • Biochemistry, Genetics and Molecular Biology(all)
  • Chemistry (miscellaneous)
  • Applied Microbiology and Biotechnology
  • Food Science

Cite this

Evaluation of multi-target and single-target liposomal drugs for the treatment of gastric cancer. / Chen, Chien Ho; Liu, Der Zen; Fang, Hsu Wei; Liang, Hong Jen; Yang, Tzu Sheng; Lin, Shyr Yi.

In: Bioscience, Biotechnology and Biochemistry, Vol. 72, No. 6, 2008, p. 1586-1594.

Research output: Contribution to journalArticle

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