Evaluation of genotoxicity of Antrodia cinnamomea in the Ames test and the in vitro chromosomal aberration test

Ming Fang Wu, Fu Chuo Peng, Yung Liang Chen, Ching Sung Lee, Yi Yuan Yang, Ming Yang Yeh, Chi Ming Liu, Jin Biou Chang, Rick Sai Chuen Wu, Chieh Chih Yu, Hsu Feng Lu, Jing Gung Chung

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12 Citations (Scopus)

Abstract

Antrodia cinnamomea is an expensive and highly valued folk medicinal fungus that grows only inside the rotten trunk of Cinnamomum kanehirae, an evergreen broadleaved tree. This fungus has recently been used commercially in the formulation of nutraceuticals and functional foods in Taiwan. It has been used for centuries as a detoxificant in cases of food poisoning, diarrhea, vomiting, hepatic disease and various kinds of cancers. The present study investigated the effects of Antrodia cinnamomea on mutagenicity using a bacterial reverse mutation assay employing the Salmonella typhimurium strains TA97, TA98, TA100, TA102, and TA1535. The effects of Antrodia cinnamomea on chromosome structure were tested in Chinese hamster ovary (CHO) cells. Antrodia cinnamomea was not mutagenic in all bacterial strains and it was not genotoxic in CHO cells.

Original languageEnglish
Pages (from-to)419-423
Number of pages5
JournalIn Vivo
Volume25
Issue number3
Publication statusPublished - May 2011

Keywords

  • Ames test
  • Antrodia cinnamomea
  • Chromosomal aberration test
  • Genotoxicity

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology

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    Wu, M. F., Peng, F. C., Chen, Y. L., Lee, C. S., Yang, Y. Y., Yeh, M. Y., Liu, C. M., Chang, J. B., Wu, R. S. C., Yu, C. C., Lu, H. F., & Chung, J. G. (2011). Evaluation of genotoxicity of Antrodia cinnamomea in the Ames test and the in vitro chromosomal aberration test. In Vivo, 25(3), 419-423.