Evaluation of genotoxicity of Antrodia cinnamomea in the Ames test and the in vitro chromosomal aberration test

Ming Fang Wu, Fu Chuo Peng, Yung Liang Chen, Ching Sung Lee, Yi Yuan Yang, Ming Yang Yeh, Chi Ming Liu, Jin Biou Chang, Rick Sai Chuen Wu, Chieh Chih Yu, Hsu Feng Lu, Jing Gung Chung

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Antrodia cinnamomea is an expensive and highly valued folk medicinal fungus that grows only inside the rotten trunk of Cinnamomum kanehirae, an evergreen broadleaved tree. This fungus has recently been used commercially in the formulation of nutraceuticals and functional foods in Taiwan. It has been used for centuries as a detoxificant in cases of food poisoning, diarrhea, vomiting, hepatic disease and various kinds of cancers. The present study investigated the effects of Antrodia cinnamomea on mutagenicity using a bacterial reverse mutation assay employing the Salmonella typhimurium strains TA97, TA98, TA100, TA102, and TA1535. The effects of Antrodia cinnamomea on chromosome structure were tested in Chinese hamster ovary (CHO) cells. Antrodia cinnamomea was not mutagenic in all bacterial strains and it was not genotoxic in CHO cells.

Original languageEnglish
Pages (from-to)419-423
Number of pages5
JournalIn Vivo
Volume25
Issue number3
Publication statusPublished - May 2011

Fingerprint

Antrodia
Fungi
Aberrations
Chromosome Aberrations
Salmonella
Chromosomes
Cricetulus
Ovary
Assays
Cinnamomum
Cells
Chromosome Structures
Functional Food
Foodborne Diseases
Salmonella typhimurium
Dietary Supplements
Taiwan
Vomiting
Diarrhea
Mutation

Keywords

  • Ames test
  • Antrodia cinnamomea
  • Chromosomal aberration test
  • Genotoxicity

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology

Cite this

Wu, M. F., Peng, F. C., Chen, Y. L., Lee, C. S., Yang, Y. Y., Yeh, M. Y., ... Chung, J. G. (2011). Evaluation of genotoxicity of Antrodia cinnamomea in the Ames test and the in vitro chromosomal aberration test. In Vivo, 25(3), 419-423.

Evaluation of genotoxicity of Antrodia cinnamomea in the Ames test and the in vitro chromosomal aberration test. / Wu, Ming Fang; Peng, Fu Chuo; Chen, Yung Liang; Lee, Ching Sung; Yang, Yi Yuan; Yeh, Ming Yang; Liu, Chi Ming; Chang, Jin Biou; Wu, Rick Sai Chuen; Yu, Chieh Chih; Lu, Hsu Feng; Chung, Jing Gung.

In: In Vivo, Vol. 25, No. 3, 05.2011, p. 419-423.

Research output: Contribution to journalArticle

Wu, MF, Peng, FC, Chen, YL, Lee, CS, Yang, YY, Yeh, MY, Liu, CM, Chang, JB, Wu, RSC, Yu, CC, Lu, HF & Chung, JG 2011, 'Evaluation of genotoxicity of Antrodia cinnamomea in the Ames test and the in vitro chromosomal aberration test', In Vivo, vol. 25, no. 3, pp. 419-423.
Wu, Ming Fang ; Peng, Fu Chuo ; Chen, Yung Liang ; Lee, Ching Sung ; Yang, Yi Yuan ; Yeh, Ming Yang ; Liu, Chi Ming ; Chang, Jin Biou ; Wu, Rick Sai Chuen ; Yu, Chieh Chih ; Lu, Hsu Feng ; Chung, Jing Gung. / Evaluation of genotoxicity of Antrodia cinnamomea in the Ames test and the in vitro chromosomal aberration test. In: In Vivo. 2011 ; Vol. 25, No. 3. pp. 419-423.
@article{0e93e68613cb4139b7d09ca5c485d729,
title = "Evaluation of genotoxicity of Antrodia cinnamomea in the Ames test and the in vitro chromosomal aberration test",
abstract = "Antrodia cinnamomea is an expensive and highly valued folk medicinal fungus that grows only inside the rotten trunk of Cinnamomum kanehirae, an evergreen broadleaved tree. This fungus has recently been used commercially in the formulation of nutraceuticals and functional foods in Taiwan. It has been used for centuries as a detoxificant in cases of food poisoning, diarrhea, vomiting, hepatic disease and various kinds of cancers. The present study investigated the effects of Antrodia cinnamomea on mutagenicity using a bacterial reverse mutation assay employing the Salmonella typhimurium strains TA97, TA98, TA100, TA102, and TA1535. The effects of Antrodia cinnamomea on chromosome structure were tested in Chinese hamster ovary (CHO) cells. Antrodia cinnamomea was not mutagenic in all bacterial strains and it was not genotoxic in CHO cells.",
keywords = "Ames test, Antrodia cinnamomea, Chromosomal aberration test, Genotoxicity",
author = "Wu, {Ming Fang} and Peng, {Fu Chuo} and Chen, {Yung Liang} and Lee, {Ching Sung} and Yang, {Yi Yuan} and Yeh, {Ming Yang} and Liu, {Chi Ming} and Chang, {Jin Biou} and Wu, {Rick Sai Chuen} and Yu, {Chieh Chih} and Lu, {Hsu Feng} and Chung, {Jing Gung}",
year = "2011",
month = "5",
language = "English",
volume = "25",
pages = "419--423",
journal = "In Vivo",
issn = "0258-851X",
publisher = "International Institute of Anticancer Research",
number = "3",

}

TY - JOUR

T1 - Evaluation of genotoxicity of Antrodia cinnamomea in the Ames test and the in vitro chromosomal aberration test

AU - Wu, Ming Fang

AU - Peng, Fu Chuo

AU - Chen, Yung Liang

AU - Lee, Ching Sung

AU - Yang, Yi Yuan

AU - Yeh, Ming Yang

AU - Liu, Chi Ming

AU - Chang, Jin Biou

AU - Wu, Rick Sai Chuen

AU - Yu, Chieh Chih

AU - Lu, Hsu Feng

AU - Chung, Jing Gung

PY - 2011/5

Y1 - 2011/5

N2 - Antrodia cinnamomea is an expensive and highly valued folk medicinal fungus that grows only inside the rotten trunk of Cinnamomum kanehirae, an evergreen broadleaved tree. This fungus has recently been used commercially in the formulation of nutraceuticals and functional foods in Taiwan. It has been used for centuries as a detoxificant in cases of food poisoning, diarrhea, vomiting, hepatic disease and various kinds of cancers. The present study investigated the effects of Antrodia cinnamomea on mutagenicity using a bacterial reverse mutation assay employing the Salmonella typhimurium strains TA97, TA98, TA100, TA102, and TA1535. The effects of Antrodia cinnamomea on chromosome structure were tested in Chinese hamster ovary (CHO) cells. Antrodia cinnamomea was not mutagenic in all bacterial strains and it was not genotoxic in CHO cells.

AB - Antrodia cinnamomea is an expensive and highly valued folk medicinal fungus that grows only inside the rotten trunk of Cinnamomum kanehirae, an evergreen broadleaved tree. This fungus has recently been used commercially in the formulation of nutraceuticals and functional foods in Taiwan. It has been used for centuries as a detoxificant in cases of food poisoning, diarrhea, vomiting, hepatic disease and various kinds of cancers. The present study investigated the effects of Antrodia cinnamomea on mutagenicity using a bacterial reverse mutation assay employing the Salmonella typhimurium strains TA97, TA98, TA100, TA102, and TA1535. The effects of Antrodia cinnamomea on chromosome structure were tested in Chinese hamster ovary (CHO) cells. Antrodia cinnamomea was not mutagenic in all bacterial strains and it was not genotoxic in CHO cells.

KW - Ames test

KW - Antrodia cinnamomea

KW - Chromosomal aberration test

KW - Genotoxicity

UR - http://www.scopus.com/inward/record.url?scp=79956345902&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79956345902&partnerID=8YFLogxK

M3 - Article

C2 - 21576417

AN - SCOPUS:79956345902

VL - 25

SP - 419

EP - 423

JO - In Vivo

JF - In Vivo

SN - 0258-851X

IS - 3

ER -