Evaluation of gastric emptying in severe, burn-injured patients

O. Y.P. Hu, S. T. Ho, J. J. Wang, W. Ho, H. J. Wang, C. Y. Lin

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Objective: The aim of this study was to evaluate the possible effect of a severe burn on gastric emptying by determining the absorption kinetics of orally administered acetaminophen. Design: A prospective, controlled study. Setting: A ten-bed burn center in a 1,300-bed university hospital. Patients: Ten adult patients suffering from second-degree burn involving >20% of total body surface area and 20 normal, healthy volunteers who acted as controls. Interventions: Patients received routine treatment such as nutritional support and cimetidine. However, opiates were stopped for at least 12 hrs before the start of the study, and nonsteroidal anti-inflammatory drugs as alternatives were used. After an 8-hr fast, the subjects ingested 0.5 g acetaminophen with 200 mL of water. The plasma concentrations of acetaminophen were determined by high-performance liquid chromatography, and the absorption kinetics was estimated from determination of time to reach the maximum plasma concentration, the maximum plasma concentration, and the area under the plasma concentration-time curve. Measurements and Main Results: The mean time for reaching the maximum plasma concentration was 33 ± 24 (SD) mins in patients and 39 ± 24 mins in the healthy volunteers. The mean area under the plasma concentration-time curve from time 0 to 120 mins and the mean maximum plasma concentration were 556 ± 190 μg/mL/min and 9.5 ± 3.5 μg/mL in patients, and 539 ± 131 μg/mL/min and 7.8 ± 2.8 μg/mL in volunteers, respectively. There was no statistical difference between groups in the time to reach the maximum plasma concentration, the area under the plasma concentration-time curve from time 0 to 120 mins, and the maximum plasma concentration. The time for reaching the maximum plasma concentration was not correlated with the severity of the burn (% area of burn) and the duration of healing (days) after burn. Conclusions: We conclude that severe burn injury does not affect the kinetics of gastric emptying, and that 200 mL of water ingested 2 hrs before anesthesia is quite safe in severely burned patients. Also, the absorption kinetics of acetaminophen was not altered by burn injury.

Original languageEnglish
Pages (from-to)527-531
Number of pages5
JournalCritical Care Medicine
Volume21
Issue number4
Publication statusPublished - Jan 1 1993
Externally publishedYes

Fingerprint

Gastric Emptying
Burns
Acetaminophen
Healthy Volunteers
Opiate Alkaloids
Burn Units
Nutritional Support
Water
Body Surface Area
Cimetidine
Wounds and Injuries
Volunteers
Anti-Inflammatory Agents
Anesthesia
High Pressure Liquid Chromatography
Prospective Studies

Keywords

  • absorption
  • acetaminophen
  • burns
  • chromatography, high-performance liquid
  • fasting
  • gastric emptying
  • kinetics
  • pharmacokinetics
  • pneumoni a, aspiration
  • starvation

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

Hu, O. Y. P., Ho, S. T., Wang, J. J., Ho, W., Wang, H. J., & Lin, C. Y. (1993). Evaluation of gastric emptying in severe, burn-injured patients. Critical Care Medicine, 21(4), 527-531.

Evaluation of gastric emptying in severe, burn-injured patients. / Hu, O. Y.P.; Ho, S. T.; Wang, J. J.; Ho, W.; Wang, H. J.; Lin, C. Y.

In: Critical Care Medicine, Vol. 21, No. 4, 01.01.1993, p. 527-531.

Research output: Contribution to journalArticle

Hu, OYP, Ho, ST, Wang, JJ, Ho, W, Wang, HJ & Lin, CY 1993, 'Evaluation of gastric emptying in severe, burn-injured patients', Critical Care Medicine, vol. 21, no. 4, pp. 527-531.
Hu OYP, Ho ST, Wang JJ, Ho W, Wang HJ, Lin CY. Evaluation of gastric emptying in severe, burn-injured patients. Critical Care Medicine. 1993 Jan 1;21(4):527-531.
Hu, O. Y.P. ; Ho, S. T. ; Wang, J. J. ; Ho, W. ; Wang, H. J. ; Lin, C. Y. / Evaluation of gastric emptying in severe, burn-injured patients. In: Critical Care Medicine. 1993 ; Vol. 21, No. 4. pp. 527-531.
@article{5dcbf5aa2a404cedae91419522645bde,
title = "Evaluation of gastric emptying in severe, burn-injured patients",
abstract = "Objective: The aim of this study was to evaluate the possible effect of a severe burn on gastric emptying by determining the absorption kinetics of orally administered acetaminophen. Design: A prospective, controlled study. Setting: A ten-bed burn center in a 1,300-bed university hospital. Patients: Ten adult patients suffering from second-degree burn involving >20{\%} of total body surface area and 20 normal, healthy volunteers who acted as controls. Interventions: Patients received routine treatment such as nutritional support and cimetidine. However, opiates were stopped for at least 12 hrs before the start of the study, and nonsteroidal anti-inflammatory drugs as alternatives were used. After an 8-hr fast, the subjects ingested 0.5 g acetaminophen with 200 mL of water. The plasma concentrations of acetaminophen were determined by high-performance liquid chromatography, and the absorption kinetics was estimated from determination of time to reach the maximum plasma concentration, the maximum plasma concentration, and the area under the plasma concentration-time curve. Measurements and Main Results: The mean time for reaching the maximum plasma concentration was 33 ± 24 (SD) mins in patients and 39 ± 24 mins in the healthy volunteers. The mean area under the plasma concentration-time curve from time 0 to 120 mins and the mean maximum plasma concentration were 556 ± 190 μg/mL/min and 9.5 ± 3.5 μg/mL in patients, and 539 ± 131 μg/mL/min and 7.8 ± 2.8 μg/mL in volunteers, respectively. There was no statistical difference between groups in the time to reach the maximum plasma concentration, the area under the plasma concentration-time curve from time 0 to 120 mins, and the maximum plasma concentration. The time for reaching the maximum plasma concentration was not correlated with the severity of the burn ({\%} area of burn) and the duration of healing (days) after burn. Conclusions: We conclude that severe burn injury does not affect the kinetics of gastric emptying, and that 200 mL of water ingested 2 hrs before anesthesia is quite safe in severely burned patients. Also, the absorption kinetics of acetaminophen was not altered by burn injury.",
keywords = "absorption, acetaminophen, burns, chromatography, high-performance liquid, fasting, gastric emptying, kinetics, pharmacokinetics, pneumoni a, aspiration, starvation",
author = "Hu, {O. Y.P.} and Ho, {S. T.} and Wang, {J. J.} and W. Ho and Wang, {H. J.} and Lin, {C. Y.}",
year = "1993",
month = "1",
day = "1",
language = "English",
volume = "21",
pages = "527--531",
journal = "Critical Care Medicine",
issn = "0090-3493",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Evaluation of gastric emptying in severe, burn-injured patients

AU - Hu, O. Y.P.

AU - Ho, S. T.

AU - Wang, J. J.

AU - Ho, W.

AU - Wang, H. J.

AU - Lin, C. Y.

PY - 1993/1/1

Y1 - 1993/1/1

N2 - Objective: The aim of this study was to evaluate the possible effect of a severe burn on gastric emptying by determining the absorption kinetics of orally administered acetaminophen. Design: A prospective, controlled study. Setting: A ten-bed burn center in a 1,300-bed university hospital. Patients: Ten adult patients suffering from second-degree burn involving >20% of total body surface area and 20 normal, healthy volunteers who acted as controls. Interventions: Patients received routine treatment such as nutritional support and cimetidine. However, opiates were stopped for at least 12 hrs before the start of the study, and nonsteroidal anti-inflammatory drugs as alternatives were used. After an 8-hr fast, the subjects ingested 0.5 g acetaminophen with 200 mL of water. The plasma concentrations of acetaminophen were determined by high-performance liquid chromatography, and the absorption kinetics was estimated from determination of time to reach the maximum plasma concentration, the maximum plasma concentration, and the area under the plasma concentration-time curve. Measurements and Main Results: The mean time for reaching the maximum plasma concentration was 33 ± 24 (SD) mins in patients and 39 ± 24 mins in the healthy volunteers. The mean area under the plasma concentration-time curve from time 0 to 120 mins and the mean maximum plasma concentration were 556 ± 190 μg/mL/min and 9.5 ± 3.5 μg/mL in patients, and 539 ± 131 μg/mL/min and 7.8 ± 2.8 μg/mL in volunteers, respectively. There was no statistical difference between groups in the time to reach the maximum plasma concentration, the area under the plasma concentration-time curve from time 0 to 120 mins, and the maximum plasma concentration. The time for reaching the maximum plasma concentration was not correlated with the severity of the burn (% area of burn) and the duration of healing (days) after burn. Conclusions: We conclude that severe burn injury does not affect the kinetics of gastric emptying, and that 200 mL of water ingested 2 hrs before anesthesia is quite safe in severely burned patients. Also, the absorption kinetics of acetaminophen was not altered by burn injury.

AB - Objective: The aim of this study was to evaluate the possible effect of a severe burn on gastric emptying by determining the absorption kinetics of orally administered acetaminophen. Design: A prospective, controlled study. Setting: A ten-bed burn center in a 1,300-bed university hospital. Patients: Ten adult patients suffering from second-degree burn involving >20% of total body surface area and 20 normal, healthy volunteers who acted as controls. Interventions: Patients received routine treatment such as nutritional support and cimetidine. However, opiates were stopped for at least 12 hrs before the start of the study, and nonsteroidal anti-inflammatory drugs as alternatives were used. After an 8-hr fast, the subjects ingested 0.5 g acetaminophen with 200 mL of water. The plasma concentrations of acetaminophen were determined by high-performance liquid chromatography, and the absorption kinetics was estimated from determination of time to reach the maximum plasma concentration, the maximum plasma concentration, and the area under the plasma concentration-time curve. Measurements and Main Results: The mean time for reaching the maximum plasma concentration was 33 ± 24 (SD) mins in patients and 39 ± 24 mins in the healthy volunteers. The mean area under the plasma concentration-time curve from time 0 to 120 mins and the mean maximum plasma concentration were 556 ± 190 μg/mL/min and 9.5 ± 3.5 μg/mL in patients, and 539 ± 131 μg/mL/min and 7.8 ± 2.8 μg/mL in volunteers, respectively. There was no statistical difference between groups in the time to reach the maximum plasma concentration, the area under the plasma concentration-time curve from time 0 to 120 mins, and the maximum plasma concentration. The time for reaching the maximum plasma concentration was not correlated with the severity of the burn (% area of burn) and the duration of healing (days) after burn. Conclusions: We conclude that severe burn injury does not affect the kinetics of gastric emptying, and that 200 mL of water ingested 2 hrs before anesthesia is quite safe in severely burned patients. Also, the absorption kinetics of acetaminophen was not altered by burn injury.

KW - absorption

KW - acetaminophen

KW - burns

KW - chromatography, high-performance liquid

KW - fasting

KW - gastric emptying

KW - kinetics

KW - pharmacokinetics

KW - pneumoni a, aspiration

KW - starvation

UR - http://www.scopus.com/inward/record.url?scp=0027416147&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027416147&partnerID=8YFLogxK

M3 - Article

C2 - 8472572

AN - SCOPUS:0027416147

VL - 21

SP - 527

EP - 531

JO - Critical Care Medicine

JF - Critical Care Medicine

SN - 0090-3493

IS - 4

ER -