Evaluation of Cyberknife Treatment Planning for Prostate Cancer using the Conformal Index and the Tumor Control Probability

Chia Chun Kuo, Hsiao-Wei Yu, Kuang Wei Huang, Chiu-Ping Chen, Tao Sang Chung, Jeng-Fong Chiou, Jo-Ting Tsai

Research output: Contribution to journalArticle

Abstract

Purpose: This study was to evaluate the feasibility of dose conformity and tumor control probability calculated for CyberKnife(superscript ®) hypofractionated planning for prostate cancer.
Materials and Methods: Six patients with early prostate cancer were included in this retrospective study. They received stereotactic hypofractionation radiotherapy by CyberKnife(superscript ®). The dose prescriptions were 37.5 Gy in 5 fractions, 42 Gy in 5 fractions, or 32 Gy in 4 fractions. Dose conformity was calculated with three parameters: the conformity index (CI), the new conformity index (nCI) and the modified conformal index (mCOIN). A statistical analysis of the tumor control probability (TCP) was also calculated.
Results: The CI and nCI of the CyberKnife(superscript ®) treatment planning system are all under 1.483. All the calculated TCP values were greater than 98.3%. We added the factors pertaining to the critical organ and obtained the mCOINs. The mCOIN values were listed to compare the quality of treatment plans.
Conclusion: The conformity index value can be used to evaluate the quality of radiosurgery planning. The mCOIN values are also feasible to compare the plans.
Original languageEnglish
Pages (from-to)301-310
Number of pages10
Journal放射治療與腫瘤學
Volume15
Issue number4
DOIs
Publication statusPublished - 2008

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Prostatic Neoplasms
Neoplasms
Radiosurgery
Prescriptions
Radiotherapy
Therapeutics
Retrospective Studies

Keywords

  • 腫瘤包覆順型度
  • 腫瘤控制機率模式
  • 立體定位放射線手術
  • 電腦刀
  • Conformity index
  • Tumor control probability
  • Stereotactic radiosurgery
  • CyberKnife

Cite this

Evaluation of Cyberknife Treatment Planning for Prostate Cancer using the Conformal Index and the Tumor Control Probability. / Kuo, Chia Chun; Yu, Hsiao-Wei ; Huang, Kuang Wei; Chen, Chiu-Ping; Chung, Tao Sang; Chiou, Jeng-Fong; Tsai, Jo-Ting.

In: 放射治療與腫瘤學, Vol. 15, No. 4, 2008, p. 301-310.

Research output: Contribution to journalArticle

Kuo, Chia Chun ; Yu, Hsiao-Wei ; Huang, Kuang Wei ; Chen, Chiu-Ping ; Chung, Tao Sang ; Chiou, Jeng-Fong ; Tsai, Jo-Ting. / Evaluation of Cyberknife Treatment Planning for Prostate Cancer using the Conformal Index and the Tumor Control Probability. In: 放射治療與腫瘤學. 2008 ; Vol. 15, No. 4. pp. 301-310.
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abstract = "Purpose: This study was to evaluate the feasibility of dose conformity and tumor control probability calculated for CyberKnife(superscript {\circledR}) hypofractionated planning for prostate cancer.Materials and Methods: Six patients with early prostate cancer were included in this retrospective study. They received stereotactic hypofractionation radiotherapy by CyberKnife(superscript {\circledR}). The dose prescriptions were 37.5 Gy in 5 fractions, 42 Gy in 5 fractions, or 32 Gy in 4 fractions. Dose conformity was calculated with three parameters: the conformity index (CI), the new conformity index (nCI) and the modified conformal index (mCOIN). A statistical analysis of the tumor control probability (TCP) was also calculated.Results: The CI and nCI of the CyberKnife(superscript {\circledR}) treatment planning system are all under 1.483. All the calculated TCP values were greater than 98.3{\%}. We added the factors pertaining to the critical organ and obtained the mCOINs. The mCOIN values were listed to compare the quality of treatment plans.Conclusion: The conformity index value can be used to evaluate the quality of radiosurgery planning. The mCOIN values are also feasible to compare the plans.",
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AU - Kuo, Chia Chun

AU - Yu, Hsiao-Wei

AU - Huang, Kuang Wei

AU - Chen, Chiu-Ping

AU - Chung, Tao Sang

AU - Chiou, Jeng-Fong

AU - Tsai, Jo-Ting

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N2 - Purpose: This study was to evaluate the feasibility of dose conformity and tumor control probability calculated for CyberKnife(superscript ®) hypofractionated planning for prostate cancer.Materials and Methods: Six patients with early prostate cancer were included in this retrospective study. They received stereotactic hypofractionation radiotherapy by CyberKnife(superscript ®). The dose prescriptions were 37.5 Gy in 5 fractions, 42 Gy in 5 fractions, or 32 Gy in 4 fractions. Dose conformity was calculated with three parameters: the conformity index (CI), the new conformity index (nCI) and the modified conformal index (mCOIN). A statistical analysis of the tumor control probability (TCP) was also calculated.Results: The CI and nCI of the CyberKnife(superscript ®) treatment planning system are all under 1.483. All the calculated TCP values were greater than 98.3%. We added the factors pertaining to the critical organ and obtained the mCOINs. The mCOIN values were listed to compare the quality of treatment plans.Conclusion: The conformity index value can be used to evaluate the quality of radiosurgery planning. The mCOIN values are also feasible to compare the plans.

AB - Purpose: This study was to evaluate the feasibility of dose conformity and tumor control probability calculated for CyberKnife(superscript ®) hypofractionated planning for prostate cancer.Materials and Methods: Six patients with early prostate cancer were included in this retrospective study. They received stereotactic hypofractionation radiotherapy by CyberKnife(superscript ®). The dose prescriptions were 37.5 Gy in 5 fractions, 42 Gy in 5 fractions, or 32 Gy in 4 fractions. Dose conformity was calculated with three parameters: the conformity index (CI), the new conformity index (nCI) and the modified conformal index (mCOIN). A statistical analysis of the tumor control probability (TCP) was also calculated.Results: The CI and nCI of the CyberKnife(superscript ®) treatment planning system are all under 1.483. All the calculated TCP values were greater than 98.3%. We added the factors pertaining to the critical organ and obtained the mCOINs. The mCOIN values were listed to compare the quality of treatment plans.Conclusion: The conformity index value can be used to evaluate the quality of radiosurgery planning. The mCOIN values are also feasible to compare the plans.

KW - 腫瘤包覆順型度

KW - 腫瘤控制機率模式

KW - 立體定位放射線手術

KW - 電腦刀

KW - Conformity index

KW - Tumor control probability

KW - Stereotactic radiosurgery

KW - CyberKnife

U2 - 10.6316/TRO/200815

DO - 10.6316/TRO/200815

M3 - Article

VL - 15

SP - 301

EP - 310

JO - 放射治療與腫瘤學

JF - 放射治療與腫瘤學

SN - 1023-988x

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ER -