Evaluation of Calcium Pyrophosphate Dihydrate Deposition Disease by Ultrasound

林 剛民(Kang-Min Lin), 賴 振宏(Jenn-Haung Lai), 張 德明(Deh-Ming Chang), 郭 三元(San-Yuan Kuo), 陳 政宏(Chen-Hung Chen), 侯 宗昀(Tsung-Yun Hou), 劉 峰誠(Feng-Cheng Liu), 張 棋楨(Chi-Ching Chang)

Research output: Contribution to journalArticle

Abstract

Objective: Our aim was to characterize the ultrasonographic features of patients with calcium pyrophosphate dihydrate (CPPD) deposition disease, and compare X-ray and ultrasound in evaluating CPPD deposition disease. Methods: In this retrospective study, all 71 patients between 2004 and 2007 with CPPD deposition disease proved by microscopic synovial fluid analysis were enrolled. We collected and analyzed 38 patients of those, on whom both conventional X-ray and high-resolution ultrasound had been carried out. Results: All patients were elderly (i.e.>65y/o) and mostly coexisted with osteoarthritis. The involvement of knee joint was the most common site. Popliteal cyst was detected in 9 of 71 patients. Synovial fluid analysis of 38 patients with CPPD deposition disease revealed that the average total white cell count was 25592.1±16697.8/mm^3, with significant neutrophil predominance. There was significant evidence that ultrasound was more reliable than X-ray in the diagnosis of CPPD deposition disease (p=0.002). Besides, there were no patients with CPPD deposition disease in whom X-rays suggested CPPD deposition disease, but for whom ultrasound results were negative. Conclusion: We found that bright stippled foci in the synovial fluid or around the articular region, the thin hyperechoic band parallel to the surface of the hyaline cartilage, and the calcification of fibrocartilage seen on ultrasound could represent CPPD deposits. Our data showed that ultrasound is a useful and important tool in the diagnostic investigation of patients with CPPD deposition disease.
Original languageEnglish
Pages (from-to)25-32
Number of pages8
JournalFormosan Journal of Rheumatology
Volume23
Issue number1
Publication statusPublished - 2009

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Synovial Fluid
X-Rays
Popliteal Cyst
Calcium Pyrophosphate
Fibrocartilage
Hyaline Cartilage
Chondrocalcinosis 2
Knee Joint
Osteoarthritis
Neutrophils
Retrospective Studies
Cell Count
Joints

Keywords

  • 超音波
  • 雙氫氧化焦磷酸鈣
  • 假性痛風
  • 軟骨鈣化
  • 關節液分析
  • Ultrasound
  • calcium pyrophosphate dihydrate
  • pseudogout
  • chondrocalcinosis
  • synovial fluid analysis

Cite this

林剛民(Kang-Min L, 賴振宏(Jenn-Haung L, 張德明(Deh-Ming C, 郭三元(San-Yuan K, 陳政宏(Chen-Hung C, 侯宗昀(Tsung-Yun H, ... 張棋楨(Chi-Ching C (2009). Evaluation of Calcium Pyrophosphate Dihydrate Deposition Disease by Ultrasound. Formosan Journal of Rheumatology, 23(1), 25-32.

Evaluation of Calcium Pyrophosphate Dihydrate Deposition Disease by Ultrasound. / 林剛民(Kang-Min Lin); 賴振宏(Jenn-Haung Lai); 張德明(Deh-Ming Chang); 郭三元(San-Yuan Kuo); 陳政宏(Chen-Hung Chen); 侯宗昀(Tsung-Yun Hou); 劉峰誠(Feng-Cheng Liu); 張棋楨(Chi-Ching Chang).

In: Formosan Journal of Rheumatology, Vol. 23, No. 1, 2009, p. 25-32.

Research output: Contribution to journalArticle

林剛民(Kang-MinL, 賴振宏(Jenn-HaungL, 張德明(Deh-MingC, 郭三元(San-YuanK, 陳政宏(Chen-HungC, 侯宗昀(Tsung-YunH, 劉峰誠(Feng-ChengL & 張棋楨(Chi-ChingC 2009, 'Evaluation of Calcium Pyrophosphate Dihydrate Deposition Disease by Ultrasound', Formosan Journal of Rheumatology, vol. 23, no. 1, pp. 25-32.
林剛民(Kang-MinL, 賴振宏(Jenn-HaungL, 張德明(Deh-MingC, 郭三元(San-YuanK, 陳政宏(Chen-HungC, 侯宗昀(Tsung-YunH et al. Evaluation of Calcium Pyrophosphate Dihydrate Deposition Disease by Ultrasound. Formosan Journal of Rheumatology. 2009;23(1):25-32.
林剛民(Kang-Min Lin) ; 賴振宏(Jenn-Haung Lai) ; 張德明(Deh-Ming Chang) ; 郭三元(San-Yuan Kuo) ; 陳政宏(Chen-Hung Chen) ; 侯宗昀(Tsung-Yun Hou) ; 劉峰誠(Feng-Cheng Liu) ; 張棋楨(Chi-Ching Chang). / Evaluation of Calcium Pyrophosphate Dihydrate Deposition Disease by Ultrasound. In: Formosan Journal of Rheumatology. 2009 ; Vol. 23, No. 1. pp. 25-32.
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abstract = "Objective: Our aim was to characterize the ultrasonographic features of patients with calcium pyrophosphate dihydrate (CPPD) deposition disease, and compare X-ray and ultrasound in evaluating CPPD deposition disease. Methods: In this retrospective study, all 71 patients between 2004 and 2007 with CPPD deposition disease proved by microscopic synovial fluid analysis were enrolled. We collected and analyzed 38 patients of those, on whom both conventional X-ray and high-resolution ultrasound had been carried out. Results: All patients were elderly (i.e.>65y/o) and mostly coexisted with osteoarthritis. The involvement of knee joint was the most common site. Popliteal cyst was detected in 9 of 71 patients. Synovial fluid analysis of 38 patients with CPPD deposition disease revealed that the average total white cell count was 25592.1±16697.8/mm^3, with significant neutrophil predominance. There was significant evidence that ultrasound was more reliable than X-ray in the diagnosis of CPPD deposition disease (p=0.002). Besides, there were no patients with CPPD deposition disease in whom X-rays suggested CPPD deposition disease, but for whom ultrasound results were negative. Conclusion: We found that bright stippled foci in the synovial fluid or around the articular region, the thin hyperechoic band parallel to the surface of the hyaline cartilage, and the calcification of fibrocartilage seen on ultrasound could represent CPPD deposits. Our data showed that ultrasound is a useful and important tool in the diagnostic investigation of patients with CPPD deposition disease.",
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T1 - Evaluation of Calcium Pyrophosphate Dihydrate Deposition Disease by Ultrasound

AU - 林, 剛民(Kang-Min Lin)

AU - 賴, 振宏(Jenn-Haung Lai)

AU - 張, 德明(Deh-Ming Chang)

AU - 郭, 三元(San-Yuan Kuo)

AU - 陳, 政宏(Chen-Hung Chen)

AU - 侯, 宗昀(Tsung-Yun Hou)

AU - 劉, 峰誠(Feng-Cheng Liu)

AU - 張, 棋楨(Chi-Ching Chang)

PY - 2009

Y1 - 2009

N2 - Objective: Our aim was to characterize the ultrasonographic features of patients with calcium pyrophosphate dihydrate (CPPD) deposition disease, and compare X-ray and ultrasound in evaluating CPPD deposition disease. Methods: In this retrospective study, all 71 patients between 2004 and 2007 with CPPD deposition disease proved by microscopic synovial fluid analysis were enrolled. We collected and analyzed 38 patients of those, on whom both conventional X-ray and high-resolution ultrasound had been carried out. Results: All patients were elderly (i.e.>65y/o) and mostly coexisted with osteoarthritis. The involvement of knee joint was the most common site. Popliteal cyst was detected in 9 of 71 patients. Synovial fluid analysis of 38 patients with CPPD deposition disease revealed that the average total white cell count was 25592.1±16697.8/mm^3, with significant neutrophil predominance. There was significant evidence that ultrasound was more reliable than X-ray in the diagnosis of CPPD deposition disease (p=0.002). Besides, there were no patients with CPPD deposition disease in whom X-rays suggested CPPD deposition disease, but for whom ultrasound results were negative. Conclusion: We found that bright stippled foci in the synovial fluid or around the articular region, the thin hyperechoic band parallel to the surface of the hyaline cartilage, and the calcification of fibrocartilage seen on ultrasound could represent CPPD deposits. Our data showed that ultrasound is a useful and important tool in the diagnostic investigation of patients with CPPD deposition disease.

AB - Objective: Our aim was to characterize the ultrasonographic features of patients with calcium pyrophosphate dihydrate (CPPD) deposition disease, and compare X-ray and ultrasound in evaluating CPPD deposition disease. Methods: In this retrospective study, all 71 patients between 2004 and 2007 with CPPD deposition disease proved by microscopic synovial fluid analysis were enrolled. We collected and analyzed 38 patients of those, on whom both conventional X-ray and high-resolution ultrasound had been carried out. Results: All patients were elderly (i.e.>65y/o) and mostly coexisted with osteoarthritis. The involvement of knee joint was the most common site. Popliteal cyst was detected in 9 of 71 patients. Synovial fluid analysis of 38 patients with CPPD deposition disease revealed that the average total white cell count was 25592.1±16697.8/mm^3, with significant neutrophil predominance. There was significant evidence that ultrasound was more reliable than X-ray in the diagnosis of CPPD deposition disease (p=0.002). Besides, there were no patients with CPPD deposition disease in whom X-rays suggested CPPD deposition disease, but for whom ultrasound results were negative. Conclusion: We found that bright stippled foci in the synovial fluid or around the articular region, the thin hyperechoic band parallel to the surface of the hyaline cartilage, and the calcification of fibrocartilage seen on ultrasound could represent CPPD deposits. Our data showed that ultrasound is a useful and important tool in the diagnostic investigation of patients with CPPD deposition disease.

KW - 超音波

KW - 雙氫氧化焦磷酸鈣

KW - 假性痛風

KW - 軟骨鈣化

KW - 關節液分析

KW - Ultrasound

KW - calcium pyrophosphate dihydrate

KW - pseudogout

KW - chondrocalcinosis

KW - synovial fluid analysis

M3 - Article

VL - 23

SP - 25

EP - 32

JO - Formosan Journal of Rheumatology

JF - Formosan Journal of Rheumatology

SN - 2075-0374

IS - 1

ER -