Evaluation of an epoxy-fixed biological patch with ionically bound heparin as a pericardial substitute

Hsing Wen Sung, Yen Chang, Yung Tsung Chiu, Hung Liang Hsu, Chin Chin Shih, Jen Her Lu, Ping Cheng Yang

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

In an attempt to develop an improved pericardial substitute, we undertook the development of an epoxy-fixed biological patch with ionically bound heparin. The study was to evaluate the cross-linking characteristics of this newly developed biological patch using its glutaraldehyde-fixed counterpart as a control. In addition, the feasibility of using this newly developed biological patch as a pericardial substitute was assessed in a canine model. In the study, it was observed that the epoxy-fixed biological patch appeared more similar to the native pericardium in colour and was more pliable than its glutaraldehyde-fixed counterpart. Also, both the epoxy- and glutaraldehyde-fixed biological patches had significant increases in fixation index and denaturation temperature as compared to the fresh one (p < 0.05). In the canine study, the epoxy-fixed biological patch with ionically bound heparin was found to have significantly less adhesion formation than those currently used clinically (p < 0.05).

Original languageEnglish
Pages (from-to)1693-1701
Number of pages9
JournalBiomaterials
Volume17
Issue number17
DOIs
Publication statusPublished - Sep 1996
Externally publishedYes

Keywords

  • Adhesion formation
  • Biological patch
  • Cross-linking characteristics
  • Epoxy
  • Glutaraldehyde
  • Pericardial substitute

ASJC Scopus subject areas

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

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