Evaluation of accuracy of FAD-GDH- and mutant Q-GDH-based blood glucose monitors in multi-patient populations

Ta Yu Huang, Hui Wen Chang, Mei Fen Tsao, Shu Ming Chuang, Chih Chin Ni, Jun Wei Sue, Hsiu Chen Lin, Cheng Teng Hsu

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: Glucose dehydrogenases have been highly promoted to high-accuracy blood glucose (BG) monitors. The flavin adenine dinucleotide glucose dehydrogenase (FAD-GDH) and mutant variant of quinoprotein glucose dehydrogenase (Mut. Q-GDH) are widely used in high-performance BG monitors for multi-patient use. Therefore we conducted accuracy evaluation of the GDH monitors, FAD-GDH-based GM700 and Mut. Q-GDH-based Performa. Methods: Different patients were enrolled: patients with and without diabetes, patients receiving respiratory therapies, hemodialysis (HD) and peritoneal dialysis (PD) patients, and neonates. The accuracy evaluation of FAD-GDH- and Mut. Q-GDH-based monitors referred to ISO 15197:2013 which applies new criteria for the minion accuracy requirements: more than 95% of the blood glucose readings shall fall within ±. 15. mg/dL of the reference method at glucose concentration

Original languageEnglish
Pages (from-to)28-33
Number of pages6
JournalClinica Chimica Acta
Volume433
DOIs
Publication statusPublished - Jun 10 2014

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Keywords

  • Arterial blood
  • Blood glucose monitoring system
  • Glucose dehydrogenase
  • Hemodialysis
  • ISO 15197:2013
  • Neonate

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical
  • Medicine(all)

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