Evaluating the Therapeutic Efficacy of Si-Wu-Tang Decoction and Concentrated Extract in Follicular Maldevelopment-Related Menstrual Disorders Through Pharmacokinetic/Pharmacodynamic Studies

Chia Jung Lee, Alinafe Magret Kapelemera, Yi Zhe Tsai, Ching Tzu Lee, Ming Yi Xu, Ching Chiung Wang

Research output: Contribution to journalArticlepeer-review

Abstract

Si-Wu-Tang (SWT), a traditional Chinese formula, is commonly used to relieve menstrual discomfort and climacteric syndrome. Water decoction (WD) and concentrated herbal extract (CHE) are the two most common formulations of traditional Chinese medicine (TCM). However, few studies have reported the equivalency of these two formulations. In this study, 23 healthy volunteers were included to determine the pharmacokinetic (PK) equivalent dosage of WD and CHE, and 25 infertile women with follicular maldevelopment to evaluate the pharmacodynamic (PD) effects on menstrual disorders. The randomized, two-way crossover comparative PK study of SWT-WD and SWT-CHE analyzed the active component, ferulic acid. The results showed that clinical doses of 170 mL SWT-WD and 18 g SWT-CHE produced the same amount of ferulic acid in the blood. The PD study showed that patients who took both of these formulations had an initial luteinizing hormone/follicle-stimulating hormone ratio of
Original languageEnglish
Article number1245
Pages (from-to)1245
JournalFrontiers in Pharmacology
Volume11
DOIs
Publication statusPublished - Sep 4 2020

Keywords

  • ferulic acid
  • follicular maldevelopment
  • menstrual disorders
  • pharmacokinetic/pharmacodynamic
  • Si-Wu-Tang

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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