Evaluating the performance of fibronectin 1 (FN1), integrin α4β1 (ITGA4), syndecan-2 (SDC2), and glycoprotein CD44 as the potential biomarkers of oral squamous cell carcinoma (OSCC)

Ching Yu Yen, Chien Yang Huang, Ming Feng Hou, Yi Hsin Yang, Chao Hsiang Chang, Hurng Wern Huang, Chung Ho Chen, Hsueh Wei Chang

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Objectives: Some extracellular matrix genes as prognostic biomarkers for oral squamous cell carcinoma (OSCC) were evaluated. Methods: We investigated gene expression of fibronectin 1 (FN1), integrin α4β1 (ITGA4), syndecan-2 (SDC2), and glycoprotein CD44 in matched OSCC/margin tissues. Results: Areas under receiver-operating characteristic curves (AUCs) of relative mRNA expression of FN1, ITGA4, SDC2, and CD44 were 0.700, 0.677, 0.513, and 0.549, respectively. For tongue/mouth floor and edentulous ridge, AUC for FN1 and ITGA4 were 0.827 and 0.725 and sensitivities/specificities were 80%/84% and 88%/52%, respectively. Conclusion: FN1 and ITGA4 are potential OSCC biomarkers for tongue/mouth floor and edentulous ridge.

Original languageEnglish
Pages (from-to)63-72
Number of pages10
JournalBiomarkers
Volume18
Issue number1
DOIs
Publication statusPublished - Feb 2013

Keywords

  • Extracellular matrix
  • Fibronectin 1
  • Glycoprotein CD44
  • Integrin α4β1
  • Oral squamous cell carcinoma
  • Receiver-operating characteristic curves
  • Syndecan-2
  • Tumor marker

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Health, Toxicology and Mutagenesis

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