Ethosomes in hair dye products as carriers of the major compounds of black tea extracts

Meng I. Yeh, Hsiu Chin Huang, Jia Horng Liaw, Min Chuan Huang, Tzu Hua Wu, Kuei Fen Huang, Feng-Lin Hsu

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Objectives: This study describes a novel carrier, the ethosome-based system, which is composed of non-ionic surfactants, ethanol, and water. Methods: Brij®52 (non-ionic surfactants), soya phosphatidylcholine (PC), cholesterol, and the major compounds (caffeine and gallic acid) of black tea extracts were dissolved in the ethanolic phase. The aqueous phase containing Paragon III was heated to 60 °C and mixed with the previous solution. Finally, 3.4 ml NaOH (6.5 N) was added to adjust the pH level to 4.05. The mixture was centrifuged at 2000 g for two minutes, and the precipitate was taken as the end product. Black tea extracts were applied in ethosome-based formulations, and the efficacy of these formulations in penetrating nude mouse skin and in dyeing white hairs was investigated. Results: Compared with an ethanolic solution and black tea extracts, the non-ionic ethosomal delivery system dramatically enhanced the adsorption of black tea extracts onto hair surfaces in vitro. The non-ionic ethosomal system was much more efficient in delivering and facilitating the adsorption of black tea extracts to the hair surface than hydroalcoholic black tea extracts. Conclusions: This formulation may have potential for development as a hair dye and protective agent.

Original languageEnglish
Pages (from-to)868-875
Number of pages8
JournalInternational Journal of Dermatology
Volume52
Issue number7
DOIs
Publication statusPublished - Jul 2013

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Hair Dyes
Tea
Hair
Surface-Active Agents
Adsorption
Protective Agents
Gallic Acid
Caffeine
Phosphatidylcholines
Nude Mice
Ethanol
Cholesterol
Skin
Water

ASJC Scopus subject areas

  • Dermatology
  • Medicine(all)

Cite this

Ethosomes in hair dye products as carriers of the major compounds of black tea extracts. / Yeh, Meng I.; Huang, Hsiu Chin; Liaw, Jia Horng; Huang, Min Chuan; Wu, Tzu Hua; Huang, Kuei Fen; Hsu, Feng-Lin.

In: International Journal of Dermatology, Vol. 52, No. 7, 07.2013, p. 868-875.

Research output: Contribution to journalArticle

Yeh, Meng I. ; Huang, Hsiu Chin ; Liaw, Jia Horng ; Huang, Min Chuan ; Wu, Tzu Hua ; Huang, Kuei Fen ; Hsu, Feng-Lin. / Ethosomes in hair dye products as carriers of the major compounds of black tea extracts. In: International Journal of Dermatology. 2013 ; Vol. 52, No. 7. pp. 868-875.
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AU - Huang, Kuei Fen

AU - Hsu, Feng-Lin

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