Ethanolic extracts and isolated compounds from small-leaf grape (Vitis thunbergii var. taiwaniana) with antihypertensive activities

Yin Shiou Lin, Yeh Lin Lu, Guei Jane Wang, Lih Geeng Chen, Chi Luan Wen, Wen Chi Hou

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

This study aimed to investigate the antihypertensive effects of ethanolic extracts (EE) and compounds isolated from the small-leaf grape (Vitis thunbergii var. taiwaniana, VTT). The highest antiangiotensin-converting enzyme (anti-ACE) was found in stem-EE (IC50 was 69.5 μg/mL). In spontaneously hypertensive rats (SHRs), stem-EE effectively reduced blood pressure 24 h after administration of a single oral dose or when administered daily for 4 weeks. The isolated compounds, including (+)-vitisin A, ampelopsin C, and (+)-ε-viniferin, were shown to have anti-ACE and vasodilating effects against phenylephrine-induced tensions in an endothelium-intact aortic ring, with (+)-vitisin A being the most effective compound. Compared to control rats, SHRs showed significantly reduced systolic and diastolic blood pressures 24 h after a single oral dose of (+)-vitisin A (10 mg/kg) or captopril (2 mg/kg). These results suggest that the development of functional foods with VTT extracts may be beneficial for regulating blood pressure.

Original languageEnglish
Pages (from-to)7435-7441
Number of pages7
JournalJournal of Agricultural and Food Chemistry
Volume60
Issue number30
DOIs
Publication statusPublished - Aug 1 2012

Fingerprint

antihypertensive effect
Blood pressure
Vitis
Antihypertensive Agents
grapes
Blood Pressure
Rats
extracts
Inbred SHR Rats
Rat control
blood pressure
leaves
mouth
rats
Captopril
viniferins
Phenylephrine
Enzymes
Functional Food
phenylephrine

Keywords

  • (+)-vitisin A
  • angiotensin converting enzyme
  • aortic ring relaxation
  • blood pressure
  • spontaneously hypertensive rat (SHR)
  • Vitis thunbergii var. taiwaniana (VTT)

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Chemistry(all)

Cite this

Ethanolic extracts and isolated compounds from small-leaf grape (Vitis thunbergii var. taiwaniana) with antihypertensive activities. / Lin, Yin Shiou; Lu, Yeh Lin; Wang, Guei Jane; Chen, Lih Geeng; Wen, Chi Luan; Hou, Wen Chi.

In: Journal of Agricultural and Food Chemistry, Vol. 60, No. 30, 01.08.2012, p. 7435-7441.

Research output: Contribution to journalArticle

Lin, Yin Shiou ; Lu, Yeh Lin ; Wang, Guei Jane ; Chen, Lih Geeng ; Wen, Chi Luan ; Hou, Wen Chi. / Ethanolic extracts and isolated compounds from small-leaf grape (Vitis thunbergii var. taiwaniana) with antihypertensive activities. In: Journal of Agricultural and Food Chemistry. 2012 ; Vol. 60, No. 30. pp. 7435-7441.
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