Estrogen variation during the menstrual cycle does not influence left ventricular diastolic function and untwisting rate in premenopausal women

Kuniaki Hirose, Masao Daimon, Sakiko Miyazaki, Shuo Ju Chiang, Ryoko Morimoto-Ichikawa, Masaki Maruyama, Takayuki Kawata, Hirotoshi Ohmura, Hiroyuki Daida

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background Although a cardioprotective effect of estrogen has been suggested by experimental studies, clinical data on the influence of estrogen on left ventricular (LV) diastolic function are sparse. The LV untwisting rate obtained by 2D speckle tracking echocardiography (2D-STE) is correlated with the time constant of LV pressure decay (tau), and this correlation is independent of left atrial pressure. Therefore, we used conventional Doppler echocardiography and 2D-STE to investigate changes in LV diastolic function during a single menstrual cycle in premenopausal women. Methods Twenty healthy premenopausal woman (mean age, 28.1 ± 2.7 years) were enrolled. Clinical and echocardiographic data were obtained during the follicular phase (F-phase) and luteal phase (L-phase) of a single menstrual cycle. We compared the clinical and echocardiographic data, and estrogen levels between the two phases. Results There were no significant differences in LV diastolic parameters derived from Doppler echocardiography (E/A, p = 0.295; E/e′, p = 0.449, DcT, p = 0.178) or 2D-STE (peak untwisting rate, p = 0.892; time-to-peak untwisting, p = 0.951) between the two phases of the menstrual cycle. However, there was a significant decrease in estrogen levels between the F- and L-phases (177 ± 119 pg/ml vs. 35 ± 12 pg/ml, p < 0.0001). Conclusions LV diastolic function in healthy premenopausal women did not significantly change during the menstrual cycle. Estrogen does not appear to have a significant acute effect on LV diastolic function in premenopausal woman.

Original languageEnglish
Pages (from-to)389-393
Number of pages5
JournalJournal of Cardiology
Volume69
Issue number1
DOIs
Publication statusPublished - Jan 1 2017

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Menstrual Cycle
Left Ventricular Function
Estrogens
Echocardiography
Doppler Echocardiography
Atrial Pressure
Follicular Phase
Luteal Phase
Ventricular Pressure

Keywords

  • Diastolic function
  • Echocardiography
  • Estrogen
  • Menstrual cycle
  • Premenopausal woman

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Estrogen variation during the menstrual cycle does not influence left ventricular diastolic function and untwisting rate in premenopausal women. / Hirose, Kuniaki; Daimon, Masao; Miyazaki, Sakiko; Chiang, Shuo Ju; Morimoto-Ichikawa, Ryoko; Maruyama, Masaki; Kawata, Takayuki; Ohmura, Hirotoshi; Daida, Hiroyuki.

In: Journal of Cardiology, Vol. 69, No. 1, 01.01.2017, p. 389-393.

Research output: Contribution to journalArticle

Hirose, K, Daimon, M, Miyazaki, S, Chiang, SJ, Morimoto-Ichikawa, R, Maruyama, M, Kawata, T, Ohmura, H & Daida, H 2017, 'Estrogen variation during the menstrual cycle does not influence left ventricular diastolic function and untwisting rate in premenopausal women', Journal of Cardiology, vol. 69, no. 1, pp. 389-393. https://doi.org/10.1016/j.jjcc.2016.09.008
Hirose, Kuniaki ; Daimon, Masao ; Miyazaki, Sakiko ; Chiang, Shuo Ju ; Morimoto-Ichikawa, Ryoko ; Maruyama, Masaki ; Kawata, Takayuki ; Ohmura, Hirotoshi ; Daida, Hiroyuki. / Estrogen variation during the menstrual cycle does not influence left ventricular diastolic function and untwisting rate in premenopausal women. In: Journal of Cardiology. 2017 ; Vol. 69, No. 1. pp. 389-393.
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abstract = "Background Although a cardioprotective effect of estrogen has been suggested by experimental studies, clinical data on the influence of estrogen on left ventricular (LV) diastolic function are sparse. The LV untwisting rate obtained by 2D speckle tracking echocardiography (2D-STE) is correlated with the time constant of LV pressure decay (tau), and this correlation is independent of left atrial pressure. Therefore, we used conventional Doppler echocardiography and 2D-STE to investigate changes in LV diastolic function during a single menstrual cycle in premenopausal women. Methods Twenty healthy premenopausal woman (mean age, 28.1 ± 2.7 years) were enrolled. Clinical and echocardiographic data were obtained during the follicular phase (F-phase) and luteal phase (L-phase) of a single menstrual cycle. We compared the clinical and echocardiographic data, and estrogen levels between the two phases. Results There were no significant differences in LV diastolic parameters derived from Doppler echocardiography (E/A, p = 0.295; E/e′, p = 0.449, DcT, p = 0.178) or 2D-STE (peak untwisting rate, p = 0.892; time-to-peak untwisting, p = 0.951) between the two phases of the menstrual cycle. However, there was a significant decrease in estrogen levels between the F- and L-phases (177 ± 119 pg/ml vs. 35 ± 12 pg/ml, p < 0.0001). Conclusions LV diastolic function in healthy premenopausal women did not significantly change during the menstrual cycle. Estrogen does not appear to have a significant acute effect on LV diastolic function in premenopausal woman.",
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T1 - Estrogen variation during the menstrual cycle does not influence left ventricular diastolic function and untwisting rate in premenopausal women

AU - Hirose, Kuniaki

AU - Daimon, Masao

AU - Miyazaki, Sakiko

AU - Chiang, Shuo Ju

AU - Morimoto-Ichikawa, Ryoko

AU - Maruyama, Masaki

AU - Kawata, Takayuki

AU - Ohmura, Hirotoshi

AU - Daida, Hiroyuki

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Y1 - 2017/1/1

N2 - Background Although a cardioprotective effect of estrogen has been suggested by experimental studies, clinical data on the influence of estrogen on left ventricular (LV) diastolic function are sparse. The LV untwisting rate obtained by 2D speckle tracking echocardiography (2D-STE) is correlated with the time constant of LV pressure decay (tau), and this correlation is independent of left atrial pressure. Therefore, we used conventional Doppler echocardiography and 2D-STE to investigate changes in LV diastolic function during a single menstrual cycle in premenopausal women. Methods Twenty healthy premenopausal woman (mean age, 28.1 ± 2.7 years) were enrolled. Clinical and echocardiographic data were obtained during the follicular phase (F-phase) and luteal phase (L-phase) of a single menstrual cycle. We compared the clinical and echocardiographic data, and estrogen levels between the two phases. Results There were no significant differences in LV diastolic parameters derived from Doppler echocardiography (E/A, p = 0.295; E/e′, p = 0.449, DcT, p = 0.178) or 2D-STE (peak untwisting rate, p = 0.892; time-to-peak untwisting, p = 0.951) between the two phases of the menstrual cycle. However, there was a significant decrease in estrogen levels between the F- and L-phases (177 ± 119 pg/ml vs. 35 ± 12 pg/ml, p < 0.0001). Conclusions LV diastolic function in healthy premenopausal women did not significantly change during the menstrual cycle. Estrogen does not appear to have a significant acute effect on LV diastolic function in premenopausal woman.

AB - Background Although a cardioprotective effect of estrogen has been suggested by experimental studies, clinical data on the influence of estrogen on left ventricular (LV) diastolic function are sparse. The LV untwisting rate obtained by 2D speckle tracking echocardiography (2D-STE) is correlated with the time constant of LV pressure decay (tau), and this correlation is independent of left atrial pressure. Therefore, we used conventional Doppler echocardiography and 2D-STE to investigate changes in LV diastolic function during a single menstrual cycle in premenopausal women. Methods Twenty healthy premenopausal woman (mean age, 28.1 ± 2.7 years) were enrolled. Clinical and echocardiographic data were obtained during the follicular phase (F-phase) and luteal phase (L-phase) of a single menstrual cycle. We compared the clinical and echocardiographic data, and estrogen levels between the two phases. Results There were no significant differences in LV diastolic parameters derived from Doppler echocardiography (E/A, p = 0.295; E/e′, p = 0.449, DcT, p = 0.178) or 2D-STE (peak untwisting rate, p = 0.892; time-to-peak untwisting, p = 0.951) between the two phases of the menstrual cycle. However, there was a significant decrease in estrogen levels between the F- and L-phases (177 ± 119 pg/ml vs. 35 ± 12 pg/ml, p < 0.0001). Conclusions LV diastolic function in healthy premenopausal women did not significantly change during the menstrual cycle. Estrogen does not appear to have a significant acute effect on LV diastolic function in premenopausal woman.

KW - Diastolic function

KW - Echocardiography

KW - Estrogen

KW - Menstrual cycle

KW - Premenopausal woman

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