Estrogen receptor-β in mitochondria

implications for mitochondrial bioenergetics and tumorigenesis

Tien Ling Liao, Chii-Ruey Tzeng, Chao Lan Yu, Yi Pei Wang, Shu-Huei Kao

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Estrogen enhances mitochondrial function by enhancing mitochondrial biogenesis and sustaining mitochondrial energy-transducing capacity. Shifts in mitochondrial bioenergetic pathways from oxidative phosphorylation to glycolysis have been hypothesized to be involved in estrogen-induced tumorigenesis. Studies have shown that mitochondria are an important target of estrogen. Estrogen receptor-β (ERβ) has been shown to localize to mitochondria in a ligand-dependent or -independent manner and can affect mitochondrial bioenergetics and anti-apoptotic signaling. However, the functional role of mitochondrial ERβ in tumorigenesis remains unclear. Clinical studies of ERβ-related tumorigenesis have shown that ERβ stimulates mitochondrial metabolism to meet the high energy demands of processes such as cell proliferation, cell survival, and transformation. Thus, in elucidating the precise role of mitochondrial ERβ in cell transformation and tumorigenesis, it will be particularly valuable to explore new approaches for the development of medical treatments targeting mitochondrial ERβ-mediated mitochondrial function and preventing apoptosis.

Original languageEnglish
Pages (from-to)52-60
Number of pages9
JournalAnnals of the New York Academy of Sciences
Volume1350
Issue number1
DOIs
Publication statusPublished - Sep 1 2015

Fingerprint

Mitochondria
Estrogen Receptors
Energy Metabolism
Carcinogenesis
Estrogens
Oxidative Phosphorylation
Cell proliferation
Organelle Biogenesis
Glycolysis
Metabolism
Estrogen
Bioenergetics
Cell Survival
Cells
Cell Proliferation
Apoptosis
Ligands

Keywords

  • bioenergetics
  • endometriosis
  • estrogen
  • estrogen receptor-β
  • mitochondrial estrogen receptor-β
  • tumorigenesis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Estrogen receptor-β in mitochondria : implications for mitochondrial bioenergetics and tumorigenesis. / Liao, Tien Ling; Tzeng, Chii-Ruey; Yu, Chao Lan; Wang, Yi Pei; Kao, Shu-Huei.

In: Annals of the New York Academy of Sciences, Vol. 1350, No. 1, 01.09.2015, p. 52-60.

Research output: Contribution to journalArticle

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