Estradiol suppresses electrically-induced arterial thrombosis by increasing prostaglandin biosynthesizing activity of the aorta in rats

Akira Ohtsu, Noriyuki Saitoh, Nobuo Okada, Wen Chang Chang, Seiitsu Murota

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The anti-thrombotic effect of estradiol was studied using an electrically induced thrombus model in rats. Estradiol treatment significantly inhibited the thrombus formation induced by electric shock. In the meantime, a stimulation of prostacyclin biosynthesis by estradiol in aortas was found. This is the first report showing the correlation between the effects of the estradiol on the thrombus formation in an experimental model and on the prostacyclin production by aortas in the same animal system.

Original languageEnglish
Pages (from-to)567-574
Number of pages8
JournalThrombosis Research
Volume32
Issue number6
DOIs
Publication statusPublished - Dec 15 1983
Externally publishedYes

Fingerprint

Prostaglandins
Aorta
Estradiol
Thrombosis
Epoprostenol
Shock
Theoretical Models

Keywords

  • Aorta
  • Estradiol
  • Prostacyclin Production
  • Thrombosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Hematology

Cite this

Estradiol suppresses electrically-induced arterial thrombosis by increasing prostaglandin biosynthesizing activity of the aorta in rats. / Ohtsu, Akira; Saitoh, Noriyuki; Okada, Nobuo; Chang, Wen Chang; Murota, Seiitsu.

In: Thrombosis Research, Vol. 32, No. 6, 15.12.1983, p. 567-574.

Research output: Contribution to journalArticle

@article{6884e5de096a4773a819a0a662a6b0f0,
title = "Estradiol suppresses electrically-induced arterial thrombosis by increasing prostaglandin biosynthesizing activity of the aorta in rats",
abstract = "The anti-thrombotic effect of estradiol was studied using an electrically induced thrombus model in rats. Estradiol treatment significantly inhibited the thrombus formation induced by electric shock. In the meantime, a stimulation of prostacyclin biosynthesis by estradiol in aortas was found. This is the first report showing the correlation between the effects of the estradiol on the thrombus formation in an experimental model and on the prostacyclin production by aortas in the same animal system.",
keywords = "Aorta, Estradiol, Prostacyclin Production, Thrombosis",
author = "Akira Ohtsu and Noriyuki Saitoh and Nobuo Okada and Chang, {Wen Chang} and Seiitsu Murota",
year = "1983",
month = "12",
day = "15",
doi = "10.1016/0049-3848(83)90058-0",
language = "English",
volume = "32",
pages = "567--574",
journal = "Thrombosis Research",
issn = "0049-3848",
publisher = "Elsevier Limited",
number = "6",

}

TY - JOUR

T1 - Estradiol suppresses electrically-induced arterial thrombosis by increasing prostaglandin biosynthesizing activity of the aorta in rats

AU - Ohtsu, Akira

AU - Saitoh, Noriyuki

AU - Okada, Nobuo

AU - Chang, Wen Chang

AU - Murota, Seiitsu

PY - 1983/12/15

Y1 - 1983/12/15

N2 - The anti-thrombotic effect of estradiol was studied using an electrically induced thrombus model in rats. Estradiol treatment significantly inhibited the thrombus formation induced by electric shock. In the meantime, a stimulation of prostacyclin biosynthesis by estradiol in aortas was found. This is the first report showing the correlation between the effects of the estradiol on the thrombus formation in an experimental model and on the prostacyclin production by aortas in the same animal system.

AB - The anti-thrombotic effect of estradiol was studied using an electrically induced thrombus model in rats. Estradiol treatment significantly inhibited the thrombus formation induced by electric shock. In the meantime, a stimulation of prostacyclin biosynthesis by estradiol in aortas was found. This is the first report showing the correlation between the effects of the estradiol on the thrombus formation in an experimental model and on the prostacyclin production by aortas in the same animal system.

KW - Aorta

KW - Estradiol

KW - Prostacyclin Production

KW - Thrombosis

UR - http://www.scopus.com/inward/record.url?scp=0021090541&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021090541&partnerID=8YFLogxK

U2 - 10.1016/0049-3848(83)90058-0

DO - 10.1016/0049-3848(83)90058-0

M3 - Article

C2 - 6364448

AN - SCOPUS:0021090541

VL - 32

SP - 567

EP - 574

JO - Thrombosis Research

JF - Thrombosis Research

SN - 0049-3848

IS - 6

ER -