Estradiol suppresses electrically-induced arterial thrombosis by increasing prostaglandin biosynthesizing activity of the aorta in rats

Akira Ohtsu, Noriyuki Saitoh, Nobuo Okada, Wen Chang Chang, Seiitsu Murota

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The anti-thrombotic effect of estradiol was studied using an electrically induced thrombus model in rats. Estradiol treatment significantly inhibited the thrombus formation induced by electric shock. In the meantime, a stimulation of prostacyclin biosynthesis by estradiol in aortas was found. This is the first report showing the correlation between the effects of the estradiol on the thrombus formation in an experimental model and on the prostacyclin production by aortas in the same animal system.

Original languageEnglish
Pages (from-to)567-574
Number of pages8
JournalThrombosis Research
Volume32
Issue number6
DOIs
Publication statusPublished - Dec 15 1983
Externally publishedYes

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Keywords

  • Aorta
  • Estradiol
  • Prostacyclin Production
  • Thrombosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Hematology

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