Estimates of relative risks for cancers in a population after prolonged low-dose-rate radiation exposure: A follow-up assessment from 1983 to 2005

Su Lun Hwang, Jing Shiang Hwang, Yi Ta Yang, Wanhua A. Hsieh, Tien Chun Chang, How Ran Guo, Mong Hsun Tsai, Jih Luh Tang, I. Feng Lin, Wushou Peter Chang

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Abstract

Radiation effects on cancer risks in a cohort of Taiwanese residents who received protracted low-dose-rate γ-radiation exposures from 60Co-contaminated reinforcing steel used to build their apartments were studied, and risks were compared to those in other radiation-exposed cohorts. Analyses were based on a more extended follow-up of the cohort population in which 117 cancer cases diagnosed between 1983 and 2005 among 6,242 people with an average excess cumulative exposure estimate of about 48 mGy. Cases were identified from Taiwan's National Cancer Registry. Radiation effects on cancer risk were estimated using proportional hazards models and were summarized in terms of the hazard ratio associated with a 100-mGy increase in dose (HR100mGy). A significant radiation risk was observed for leukemia excluding chronic lymphocytic leukemia (HR100mGy 1.19, 90% CI 1.01-1.31). Breast cancer exhibited a marginally significant dose response (HR100mGy 1.12, 90% CI 0.99-1.21). The results further strengthen the association between protracted low-dose radiation and cancer risks, especially for breast cancers and leukemia, in this unique cohort population.

Original languageEnglish
Pages (from-to)143-148
Number of pages6
JournalRadiation Research
Volume170
Issue number2
DOIs
Publication statusPublished - Aug 2008
Externally publishedYes

Fingerprint

radiation dosage
relative risk
cancer
dosage
neoplasms
estimates
leukemias
Population
Radiation Effects
Radiation
Neoplasms
leukemia
breast neoplasms
Leukemia
radiation effects
cumulative exposure
Breast Neoplasms
breast
hazards
lymphocytic leukemia

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Biophysics
  • Radiation

Cite this

Estimates of relative risks for cancers in a population after prolonged low-dose-rate radiation exposure : A follow-up assessment from 1983 to 2005. / Hwang, Su Lun; Hwang, Jing Shiang; Yang, Yi Ta; Hsieh, Wanhua A.; Chang, Tien Chun; Guo, How Ran; Tsai, Mong Hsun; Tang, Jih Luh; Lin, I. Feng; Chang, Wushou Peter.

In: Radiation Research, Vol. 170, No. 2, 08.2008, p. 143-148.

Research output: Contribution to journalArticle

Hwang, SL, Hwang, JS, Yang, YT, Hsieh, WA, Chang, TC, Guo, HR, Tsai, MH, Tang, JL, Lin, IF & Chang, WP 2008, 'Estimates of relative risks for cancers in a population after prolonged low-dose-rate radiation exposure: A follow-up assessment from 1983 to 2005', Radiation Research, vol. 170, no. 2, pp. 143-148. https://doi.org/10.1667/RR0732.1
Hwang, Su Lun ; Hwang, Jing Shiang ; Yang, Yi Ta ; Hsieh, Wanhua A. ; Chang, Tien Chun ; Guo, How Ran ; Tsai, Mong Hsun ; Tang, Jih Luh ; Lin, I. Feng ; Chang, Wushou Peter. / Estimates of relative risks for cancers in a population after prolonged low-dose-rate radiation exposure : A follow-up assessment from 1983 to 2005. In: Radiation Research. 2008 ; Vol. 170, No. 2. pp. 143-148.
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