ESR1, FTO, and UCP2 genes interact with bariatric surgery affecting weight loss and glycemic control in severely obese patients

Tsan Hon Liou, Hsin Hung Chen, Weu Wang, Shu Fen Wu, Yi Chih Lee, Wei Shiung Yang, Wei Jei Lee

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)

Abstract

Background: Significant variability in weight loss and glycemic control has been observed in obese patients receiving bariatric surgery. Genetic factors may play a role in the different outcomes. Methods: Five hundred and twenty severely obese patients with body mass index (BMI) ≥35 were recruited. Among them, 149 and 371 subjects received laparoscopic adjustable gastric banding (LAGB) and laparoscopic mini-gastric bypass (LMGB), respectively. All individuals were genotyped for five obesity-related single nucleotide polymorphisms on ESR1, FTO, PPARγ, and UCP2 genes to explore how these genes affect weight loss and glycemic control after bariatric surgery at the 6th month. Results: Obese patients with risk genotypes on rs660339-UCP2 had greater decrease in BMI after LAGB compared to patients with non-risk genotypes (-7.5 vs. -6 U, p=0.02). In contrast, after LMGB, obese patients with risk genotypes on either rs712221-ESR1 or rs9939609-FTO had significant decreases in BMI (risk vs. non-risk genotype, -12.5 vs. -10.0 U on rs712221, p=0.02 and -12.1 vs. -10.6 U on rs9939609, p=0.04) and a significant amelioration in HbA1c levels (p=0.038 for rs712221 and p

Original languageEnglish
Pages (from-to)1758-1765
Number of pages8
JournalObesity Surgery
Volume21
Issue number11
DOIs
Publication statusPublished - Nov 2011

Keywords

  • Bariatric surgery
  • ESR1
  • FTO
  • HbA1c
  • UCP2

ASJC Scopus subject areas

  • Surgery
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Fingerprint Dive into the research topics of 'ESR1, FTO, and UCP2 genes interact with bariatric surgery affecting weight loss and glycemic control in severely obese patients'. Together they form a unique fingerprint.

Cite this