Esophagogastric varices predict mortality in hospitalized patients with alcoholic liver disease in Taiwan

Chih Wen Lin, Yaw Sen Chen, Chung Hsu Lai, Daw Shyong Perng, Hui Ching Weng, Jui Ting Hu, Yi Wen Huang, Mei Yu Hsu, Sien Sing Yang

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Background/Aims: Alcoholic liver disease (ALD) is a major cause of morbidity and mortality in Western countries. The present study investigated the status and the risk factors for predicting mortality of ALD in Taiwan. Methodology: We retrospective studied 100 consecutive in patients with ALD between 1992 and 2000. All patients had a history of alcohol consumption exceeding 80 g per day for at least 5 years. Results: The study comprised 93 men and 7 women with a mean age of 45.4 years. The ALD included fatty liver (21%), alcoholic hepatitis (15%), alcoholic hepatitis superimposed on alcoholic cirrhosis (24%), and alcoholic cirrhosis (40%). Forty-four percent of patients had esophagogastric varices. Thirty-three percent of patients were mortality. The presence of esophagogastric varices was the only parameter identified by univariate and multivariate analyses and had a statistically significant association with increased mortality (OR: 8.603; 95% CI: 2.009-36.864; p=0.004). The cumulative survival for ALD patients with varices was significantly lower than for patients without varices. Conclusions: The presence of esophagogastric varices had a statistically significant relationship with increased mortality. This study strongly implicates esophagogastric varices were a valuable poor prognostic factor with mortality. Upper gastrointestinal endoscopy is a simple clinical available tool for the assessment of the occurrence of varices to predict the disease severity and mortality in hospitalized patients with ALD.

Original languageEnglish
Pages (from-to)305-308
Number of pages4
JournalHepato-Gastroenterology
Volume57
Issue number98
Publication statusPublished - Mar 2010
Externally publishedYes

Keywords

  • Alcoholic liver disease
  • Mortality
  • Varices

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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