Esophagogastric junction adenocarcinoma according to siewert classification in Taiwan

Wen Liang Fang, Chew Wun Wu, Jen Hao Chen, Su Shin Lo, Mao Chih Hsieh, King Han Shen, Wen Hu Hsu, Anna Fen Yau Li, Wing Yiu Lui

Research output: Contribution to journalArticle

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Abstract

Background: The incidence of adenocarcinoma of the esophagogastric junction (AEG) is rapidly increasing. We evaluated the clinicopathological difference and outcomes of Taiwanese patients with AEG according to the Siewert classification. Methods: Data were prospectively collected between December 1987 and July 2007. Two hundred thirty-one patients underwent curative resection of AEG at Taipei Veterans General Hospital and were divided into different Siewert types. The clinicopathological characteristics, operative morbidity, survival, and initial recurrence pattern were compared between the different types. Results: Fifty-one type II and 180 type III cancer patients were studied. Subtotal esophagectomy via a left thoracotomy (19.6% vs 2.8%), smaller tumor size (4.43 ± 2.04 vs. 5.35 ± 2.03 cm), and more combined organ resection (60% vs. 43.1%) were more common in type II than type III cancer. Multivariate analysis showed that three independent risk factors for death were gender, tumor size, and lymphovascular invasion. There were long-term survivors among the patients with lesser curvature site lymph node metastasis, whereas metastasis to the lymph nodes of the distal stomach and along the greater curvature site was associated with poor prognosis. The 5-year survival was similar between type II and type III cancer (59.6% vs. 63.5%, P = 0.947). Conclusions: Lymphovascular invasion, tumor size, and gender were determined to be three independent factors of survival after curative resection for AEG, and Siewert type was not associated with differences in survival.

Original languageEnglish
Pages (from-to)3237-3244
Number of pages8
JournalAnnals of Surgical Oncology
Volume16
Issue number12
DOIs
Publication statusPublished - Dec 2009

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Esophagogastric Junction
Taiwan
Adenocarcinoma
Neoplasms
Survival
Lymph Nodes
Neoplasm Metastasis
Veterans Hospitals
Esophagectomy
Thoracotomy
General Hospitals
Survivors
Stomach
Multivariate Analysis
Morbidity
Recurrence
Incidence

ASJC Scopus subject areas

  • Surgery
  • Oncology

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Esophagogastric junction adenocarcinoma according to siewert classification in Taiwan. / Fang, Wen Liang; Wu, Chew Wun; Chen, Jen Hao; Lo, Su Shin; Hsieh, Mao Chih; Shen, King Han; Hsu, Wen Hu; Li, Anna Fen Yau; Lui, Wing Yiu.

In: Annals of Surgical Oncology, Vol. 16, No. 12, 12.2009, p. 3237-3244.

Research output: Contribution to journalArticle

Fang, WL, Wu, CW, Chen, JH, Lo, SS, Hsieh, MC, Shen, KH, Hsu, WH, Li, AFY & Lui, WY 2009, 'Esophagogastric junction adenocarcinoma according to siewert classification in Taiwan', Annals of Surgical Oncology, vol. 16, no. 12, pp. 3237-3244. https://doi.org/10.1245/s10434-009-0636-9
Fang, Wen Liang ; Wu, Chew Wun ; Chen, Jen Hao ; Lo, Su Shin ; Hsieh, Mao Chih ; Shen, King Han ; Hsu, Wen Hu ; Li, Anna Fen Yau ; Lui, Wing Yiu. / Esophagogastric junction adenocarcinoma according to siewert classification in Taiwan. In: Annals of Surgical Oncology. 2009 ; Vol. 16, No. 12. pp. 3237-3244.
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