Erythroleukemia and other hematologic complications of intensive therapy in long‐term survivors of small cell lung cancer

Edward C. Bradley, Geraldine P. Schechter, Mary J. Matthews, Jacqueline Whang‐Peng, Martin H. Cohen, Paul A. Bunn, Daniel C. Ihde, John D. Minna

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Eight patients with small cell bronchogenic carcinoma treated with intensive combination chemotherapy, with and without radiotherapy, have been followed for a minimum of two and a half years without relapse. One patient, after a prodrome of macrocytic sideroblastic anemia, leukopenia, and thrombocytopenia, experienced erythroleukemia 34 months after starting chemotherapy, and cytogenetic studies revealed extensive chromosomal abnormalities. Another patient had persistent macrocytic anemia and pancytopenia two years after cessation of therapy. The remaining six patients have normal peripheral blood smears and cell counts. A significant incidence of preleukemic syndromes and acute leukemia appearing as late complications in intensively treated small cell lung cancer patients requires confirmation in larger series of long‐term survivors. Prospective determination of marrow karyotype abnormalities may help to identify patients at greatest risk for developing secondary leukemia.

Original languageEnglish
Pages (from-to)221-223
Number of pages3
JournalCancer
Volume49
Issue number2
DOIs
Publication statusPublished - Jan 1 1982
Externally publishedYes

Fingerprint

Leukemia, Erythroblastic, Acute
Small Cell Lung Carcinoma
Survivors
Macrocytic Anemia
Leukemia
Therapeutics
Sideroblastic Anemia
Pancytopenia
Small Cell Carcinoma
Blood Cell Count
Bronchogenic Carcinoma
Leukopenia
Combination Drug Therapy
Karyotype
Cytogenetics
Chromosome Aberrations
Thrombocytopenia
Radiotherapy
Bone Marrow
Recurrence

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Erythroleukemia and other hematologic complications of intensive therapy in long‐term survivors of small cell lung cancer. / Bradley, Edward C.; Schechter, Geraldine P.; Matthews, Mary J.; Whang‐Peng, Jacqueline; Cohen, Martin H.; Bunn, Paul A.; Ihde, Daniel C.; Minna, John D.

In: Cancer, Vol. 49, No. 2, 01.01.1982, p. 221-223.

Research output: Contribution to journalArticle

Bradley, Edward C. ; Schechter, Geraldine P. ; Matthews, Mary J. ; Whang‐Peng, Jacqueline ; Cohen, Martin H. ; Bunn, Paul A. ; Ihde, Daniel C. ; Minna, John D. / Erythroleukemia and other hematologic complications of intensive therapy in long‐term survivors of small cell lung cancer. In: Cancer. 1982 ; Vol. 49, No. 2. pp. 221-223.
@article{2e02d2015dc34f289ef0053d241e7aa1,
title = "Erythroleukemia and other hematologic complications of intensive therapy in long‐term survivors of small cell lung cancer",
abstract = "Eight patients with small cell bronchogenic carcinoma treated with intensive combination chemotherapy, with and without radiotherapy, have been followed for a minimum of two and a half years without relapse. One patient, after a prodrome of macrocytic sideroblastic anemia, leukopenia, and thrombocytopenia, experienced erythroleukemia 34 months after starting chemotherapy, and cytogenetic studies revealed extensive chromosomal abnormalities. Another patient had persistent macrocytic anemia and pancytopenia two years after cessation of therapy. The remaining six patients have normal peripheral blood smears and cell counts. A significant incidence of preleukemic syndromes and acute leukemia appearing as late complications in intensively treated small cell lung cancer patients requires confirmation in larger series of long‐term survivors. Prospective determination of marrow karyotype abnormalities may help to identify patients at greatest risk for developing secondary leukemia.",
author = "Bradley, {Edward C.} and Schechter, {Geraldine P.} and Matthews, {Mary J.} and Jacqueline Whang‐Peng and Cohen, {Martin H.} and Bunn, {Paul A.} and Ihde, {Daniel C.} and Minna, {John D.}",
year = "1982",
month = "1",
day = "1",
doi = "10.1002/1097-0142(19820115)49:2<221::AID-CNCR2820490204>3.0.CO;2-#",
language = "English",
volume = "49",
pages = "221--223",
journal = "Cancer",
issn = "0008-543X",
publisher = "John Wiley and Sons Inc.",
number = "2",

}

TY - JOUR

T1 - Erythroleukemia and other hematologic complications of intensive therapy in long‐term survivors of small cell lung cancer

AU - Bradley, Edward C.

AU - Schechter, Geraldine P.

AU - Matthews, Mary J.

AU - Whang‐Peng, Jacqueline

AU - Cohen, Martin H.

AU - Bunn, Paul A.

AU - Ihde, Daniel C.

AU - Minna, John D.

PY - 1982/1/1

Y1 - 1982/1/1

N2 - Eight patients with small cell bronchogenic carcinoma treated with intensive combination chemotherapy, with and without radiotherapy, have been followed for a minimum of two and a half years without relapse. One patient, after a prodrome of macrocytic sideroblastic anemia, leukopenia, and thrombocytopenia, experienced erythroleukemia 34 months after starting chemotherapy, and cytogenetic studies revealed extensive chromosomal abnormalities. Another patient had persistent macrocytic anemia and pancytopenia two years after cessation of therapy. The remaining six patients have normal peripheral blood smears and cell counts. A significant incidence of preleukemic syndromes and acute leukemia appearing as late complications in intensively treated small cell lung cancer patients requires confirmation in larger series of long‐term survivors. Prospective determination of marrow karyotype abnormalities may help to identify patients at greatest risk for developing secondary leukemia.

AB - Eight patients with small cell bronchogenic carcinoma treated with intensive combination chemotherapy, with and without radiotherapy, have been followed for a minimum of two and a half years without relapse. One patient, after a prodrome of macrocytic sideroblastic anemia, leukopenia, and thrombocytopenia, experienced erythroleukemia 34 months after starting chemotherapy, and cytogenetic studies revealed extensive chromosomal abnormalities. Another patient had persistent macrocytic anemia and pancytopenia two years after cessation of therapy. The remaining six patients have normal peripheral blood smears and cell counts. A significant incidence of preleukemic syndromes and acute leukemia appearing as late complications in intensively treated small cell lung cancer patients requires confirmation in larger series of long‐term survivors. Prospective determination of marrow karyotype abnormalities may help to identify patients at greatest risk for developing secondary leukemia.

UR - http://www.scopus.com/inward/record.url?scp=0020066866&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020066866&partnerID=8YFLogxK

U2 - 10.1002/1097-0142(19820115)49:2<221::AID-CNCR2820490204>3.0.CO;2-#

DO - 10.1002/1097-0142(19820115)49:2<221::AID-CNCR2820490204>3.0.CO;2-#

M3 - Article

C2 - 6274504

AN - SCOPUS:0020066866

VL - 49

SP - 221

EP - 223

JO - Cancer

JF - Cancer

SN - 0008-543X

IS - 2

ER -