Eradication of Helicobacter pylori significantly reduced gastric damage in nonsteroidal anti-inflammatory drug-treated Mongolian gerbils

Chun Chao Chang, Sheng-Hsuan Chen, Gi Shih Lien, Horng Yuan Lou, Ching Ruey Hsieh, Chia Lang Fang, Shiann Pan

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Aim: To examine the effect of eradication of Helicobacter pylori prior to usage of NSAIDs, by investigating gastric inflammatory activity, myeloperoxidase (MPO) activity, prostaglandin (PG) E2 synthesis in H pylori-infected, and H pylori-eradicated gerbils followed by administration of indomethacin and rofecoxib. Methods: Six-week-old male gerbils were orally inoculated with H pylori. Seven weeks later, anti-H pylori triple therapy and vehicle were given to gerbils respectively and followed by oral indomethacin (2 mg/kg·d) or rofecoxib (10 mg/kg·d) for 2 wk. We examined the area of lesions, gastric inflammatory activity, PGE2 synthesis and MPO activity in the stomach. Results: In indomethacin and rofecoxib-treated gerbils, the following results were obtained in H pylori-infected group vs H pylori-eradicated group respectively: hyperplasia area of the stomach (mm2): 82.4±9.2 vs 13.9±3.5 (P2): 14.4±4.9 vs 0.86±0.5 (P2O2/min/g tissue): 104.7±9.2 vs 9.0±2.3 (P2 synthesis (pg/mg wet weight/min): 299.2±81.5 vs 102.8±26.2 (P

Original languageEnglish
Pages (from-to)104-108
Number of pages5
JournalWorld Journal of Gastroenterology
Volume11
Issue number1
Publication statusPublished - Jan 7 2005

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Gerbillinae
Pylorus
Helicobacter pylori
Stomach
Anti-Inflammatory Agents
Indomethacin
Pharmaceutical Preparations
Dinoprostone
Peroxidase
Non-Steroidal Anti-Inflammatory Agents
Hyperplasia
Weights and Measures
rofecoxib

Keywords

  • Gastric damage
  • Helicobater pylori
  • NSAIDs

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Eradication of Helicobacter pylori significantly reduced gastric damage in nonsteroidal anti-inflammatory drug-treated Mongolian gerbils. / Chang, Chun Chao; Chen, Sheng-Hsuan; Lien, Gi Shih; Lou, Horng Yuan; Hsieh, Ching Ruey; Fang, Chia Lang; Pan, Shiann.

In: World Journal of Gastroenterology, Vol. 11, No. 1, 07.01.2005, p. 104-108.

Research output: Contribution to journalArticle

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