16 Citations (Scopus)

Abstract

Background: Eradication of Helicobacter pylori has become part of the standard therapy for peptic ulcer. However, the role of H pylori eradication in perforation of peptic ulcers remains controversial. It is unclear whether eradication of the bacterium confers prolonged ulcer remission after simple repair of perforated peptic ulcer. Methods: A systematic review and meta-analysis of randomized controlled trials was performed to evaluate the effects of H pylori eradication on prevention of ulcer recurrence after simple closure of perforated peptic ulcers. The primary outcome to evaluate these effects was the incidence of postoperative ulcers; the secondary outcome was the rate of H pylori elimination. Results: The meta-analysis included five randomized controlled trials and 401 patients. A high prevalence of H pylori infection occurred in patients with perforated peptic ulcers. Eradication of H pylori significantly reduced the incidence of ulcer recurrence at 8 wk (risk ratio 2.97; 95% confidence interval: 1.06-8.29) and 1 y (risk ratio 1.49; 95% confidence interval: 1.10-2.03) postoperation. The rate of H pylori eradication was significantly higher in the treatment group than in the nontreatment group. Conclusions: Eradication therapy should be provided to patients with H pylori infection after simple closure of perforated gastroduodenal ulcers.

Original languageEnglish
Pages (from-to)219-226
Number of pages8
JournalJournal of Surgical Research
Volume182
Issue number2
DOIs
Publication statusPublished - Jun 15 2013

Fingerprint

Pylorus
Peptic Ulcer
Helicobacter pylori
Ulcer
Meta-Analysis
Randomized Controlled Trials
Recurrence
Peptic Ulcer Perforation
Odds Ratio
Confidence Intervals
Incidence
Infection
Therapeutics
Bacteria

Keywords

  • Helicobacter pylori eradication
  • Meta-analysis
  • Perforated peptic ulcer

ASJC Scopus subject areas

  • Surgery

Cite this

Eradication of Helicobacter pylori for prevention of ulcer recurrence after simple closure of perforated peptic ulcer : A meta-analysis of randomized controlled trials. / Wong, Chung Shun; Chia, Chee Fah; Lee, Hung Chia; Wei, Po-Li; Ma, Hon-Ping; Tsai, Shin-Han; Wu, Chih-Hsiung; Tam, Ka-Wai.

In: Journal of Surgical Research, Vol. 182, No. 2, 15.06.2013, p. 219-226.

Research output: Contribution to journalArticle

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abstract = "Background: Eradication of Helicobacter pylori has become part of the standard therapy for peptic ulcer. However, the role of H pylori eradication in perforation of peptic ulcers remains controversial. It is unclear whether eradication of the bacterium confers prolonged ulcer remission after simple repair of perforated peptic ulcer. Methods: A systematic review and meta-analysis of randomized controlled trials was performed to evaluate the effects of H pylori eradication on prevention of ulcer recurrence after simple closure of perforated peptic ulcers. The primary outcome to evaluate these effects was the incidence of postoperative ulcers; the secondary outcome was the rate of H pylori elimination. Results: The meta-analysis included five randomized controlled trials and 401 patients. A high prevalence of H pylori infection occurred in patients with perforated peptic ulcers. Eradication of H pylori significantly reduced the incidence of ulcer recurrence at 8 wk (risk ratio 2.97; 95{\%} confidence interval: 1.06-8.29) and 1 y (risk ratio 1.49; 95{\%} confidence interval: 1.10-2.03) postoperation. The rate of H pylori eradication was significantly higher in the treatment group than in the nontreatment group. Conclusions: Eradication therapy should be provided to patients with H pylori infection after simple closure of perforated gastroduodenal ulcers.",
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author = "Wong, {Chung Shun} and Chia, {Chee Fah} and Lee, {Hung Chia} and Po-Li Wei and Hon-Ping Ma and Shin-Han Tsai and Chih-Hsiung Wu and Ka-Wai Tam",
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T1 - Eradication of Helicobacter pylori for prevention of ulcer recurrence after simple closure of perforated peptic ulcer

T2 - A meta-analysis of randomized controlled trials

AU - Wong, Chung Shun

AU - Chia, Chee Fah

AU - Lee, Hung Chia

AU - Wei, Po-Li

AU - Ma, Hon-Ping

AU - Tsai, Shin-Han

AU - Wu, Chih-Hsiung

AU - Tam, Ka-Wai

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N2 - Background: Eradication of Helicobacter pylori has become part of the standard therapy for peptic ulcer. However, the role of H pylori eradication in perforation of peptic ulcers remains controversial. It is unclear whether eradication of the bacterium confers prolonged ulcer remission after simple repair of perforated peptic ulcer. Methods: A systematic review and meta-analysis of randomized controlled trials was performed to evaluate the effects of H pylori eradication on prevention of ulcer recurrence after simple closure of perforated peptic ulcers. The primary outcome to evaluate these effects was the incidence of postoperative ulcers; the secondary outcome was the rate of H pylori elimination. Results: The meta-analysis included five randomized controlled trials and 401 patients. A high prevalence of H pylori infection occurred in patients with perforated peptic ulcers. Eradication of H pylori significantly reduced the incidence of ulcer recurrence at 8 wk (risk ratio 2.97; 95% confidence interval: 1.06-8.29) and 1 y (risk ratio 1.49; 95% confidence interval: 1.10-2.03) postoperation. The rate of H pylori eradication was significantly higher in the treatment group than in the nontreatment group. Conclusions: Eradication therapy should be provided to patients with H pylori infection after simple closure of perforated gastroduodenal ulcers.

AB - Background: Eradication of Helicobacter pylori has become part of the standard therapy for peptic ulcer. However, the role of H pylori eradication in perforation of peptic ulcers remains controversial. It is unclear whether eradication of the bacterium confers prolonged ulcer remission after simple repair of perforated peptic ulcer. Methods: A systematic review and meta-analysis of randomized controlled trials was performed to evaluate the effects of H pylori eradication on prevention of ulcer recurrence after simple closure of perforated peptic ulcers. The primary outcome to evaluate these effects was the incidence of postoperative ulcers; the secondary outcome was the rate of H pylori elimination. Results: The meta-analysis included five randomized controlled trials and 401 patients. A high prevalence of H pylori infection occurred in patients with perforated peptic ulcers. Eradication of H pylori significantly reduced the incidence of ulcer recurrence at 8 wk (risk ratio 2.97; 95% confidence interval: 1.06-8.29) and 1 y (risk ratio 1.49; 95% confidence interval: 1.10-2.03) postoperation. The rate of H pylori eradication was significantly higher in the treatment group than in the nontreatment group. Conclusions: Eradication therapy should be provided to patients with H pylori infection after simple closure of perforated gastroduodenal ulcers.

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