Epstein-Barr virus infected lymphoepithelial carcinomas of the salivary gland in the Russia-Asia area: A clinicopathologic study of 160 cases

Takashi Saku, Jun Cheng, Yu Jen Kai, Masayoshi Tokunaga, Jian Li, Weiguo Zhang, Airu Liu, Lanyan Wu, Yong Lu, Zhiyu Zhou, Yingfang Li, Ruyao Li, Jei Ouyang, Lianjia Yang, Shifeng Yu, Tiecheng Lou, Suozhi Wang, Dyisheng Lin, Huilan Rao, Hanliang LinPatima Sderk, Zhaolun Chen, Zhirong Chen, Chonghong Cai, Hyunjung Kim, Sanpyo Hong

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

In order to determine the prevalence of the Epstein-Barr virus (EBV) infection in salivary gland lymphoepithelial carcinomas (LEC), we have collected 160 cases from Asian countries and Russia. All the cases examined by PCR for EBV DNA BamHI fragment and in-situ hybridization for EBER-1, EBV encoded small RNA, showed positivity for EBV infection in LEC cells, while no positive signals were found in any other salivary neoplasm examined. The incidence of LEC was highest in Guanzhou, followed by Shanghai and Chengdu and lowest in the Northern parts of China, Seoul, Niigata, and Moscow. The mean age of the patients with LEC was 43.9 years with no sex predilection. The Chinese patients were of the Han race, only including minor races. There were ninety-five cases found with LEC in the parotid gland (75%), 20 in the submandibular gland (5%), and 28 in the minor salivary gland (20%). Histologically, the LECs were classified into two types: small nest type and large nest type. The latter type consisted of large-sized tumor cell nests and dense lymphocytic stromata and more frequently occurred in the minor salivary gland. The former consisted of small-sized tumor cell nests with fibrous and lymphocyte-depleted stromata, which were more frequently found in the parotid gland. The results indicated that EBV infection and certain geographic factors play important roles in the pathogenesis of the salivary LEC.

Original languageEnglish
Pages (from-to)35-39
Number of pages5
JournalArkhiv Patologii
Volume65
Issue number2
Publication statusPublished - 2003
Externally publishedYes

Fingerprint

Russia
Salivary Glands
Human Herpesvirus 4
Carcinoma
Epstein-Barr Virus Infections
Minor Salivary Glands
Parotid Gland
Neoplasms
Moscow
Geography
Submandibular Gland
In Situ Hybridization
China
Lymphocytes
RNA
Polymerase Chain Reaction
DNA
Incidence

Keywords

  • Epstein-Barr virus
  • Lymphoepithelial carcinoma of the salivary gland
  • Salivary gland tumors

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Saku, T., Cheng, J., Kai, Y. J., Tokunaga, M., Li, J., Zhang, W., ... Hong, S. (2003). Epstein-Barr virus infected lymphoepithelial carcinomas of the salivary gland in the Russia-Asia area: A clinicopathologic study of 160 cases. Arkhiv Patologii, 65(2), 35-39.

Epstein-Barr virus infected lymphoepithelial carcinomas of the salivary gland in the Russia-Asia area : A clinicopathologic study of 160 cases. / Saku, Takashi; Cheng, Jun; Kai, Yu Jen; Tokunaga, Masayoshi; Li, Jian; Zhang, Weiguo; Liu, Airu; Wu, Lanyan; Lu, Yong; Zhou, Zhiyu; Li, Yingfang; Li, Ruyao; Ouyang, Jei; Yang, Lianjia; Yu, Shifeng; Lou, Tiecheng; Wang, Suozhi; Lin, Dyisheng; Rao, Huilan; Lin, Hanliang; Sderk, Patima; Chen, Zhaolun; Chen, Zhirong; Cai, Chonghong; Kim, Hyunjung; Hong, Sanpyo.

In: Arkhiv Patologii, Vol. 65, No. 2, 2003, p. 35-39.

Research output: Contribution to journalArticle

Saku, T, Cheng, J, Kai, YJ, Tokunaga, M, Li, J, Zhang, W, Liu, A, Wu, L, Lu, Y, Zhou, Z, Li, Y, Li, R, Ouyang, J, Yang, L, Yu, S, Lou, T, Wang, S, Lin, D, Rao, H, Lin, H, Sderk, P, Chen, Z, Chen, Z, Cai, C, Kim, H & Hong, S 2003, 'Epstein-Barr virus infected lymphoepithelial carcinomas of the salivary gland in the Russia-Asia area: A clinicopathologic study of 160 cases', Arkhiv Patologii, vol. 65, no. 2, pp. 35-39.
Saku, Takashi ; Cheng, Jun ; Kai, Yu Jen ; Tokunaga, Masayoshi ; Li, Jian ; Zhang, Weiguo ; Liu, Airu ; Wu, Lanyan ; Lu, Yong ; Zhou, Zhiyu ; Li, Yingfang ; Li, Ruyao ; Ouyang, Jei ; Yang, Lianjia ; Yu, Shifeng ; Lou, Tiecheng ; Wang, Suozhi ; Lin, Dyisheng ; Rao, Huilan ; Lin, Hanliang ; Sderk, Patima ; Chen, Zhaolun ; Chen, Zhirong ; Cai, Chonghong ; Kim, Hyunjung ; Hong, Sanpyo. / Epstein-Barr virus infected lymphoepithelial carcinomas of the salivary gland in the Russia-Asia area : A clinicopathologic study of 160 cases. In: Arkhiv Patologii. 2003 ; Vol. 65, No. 2. pp. 35-39.
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abstract = "In order to determine the prevalence of the Epstein-Barr virus (EBV) infection in salivary gland lymphoepithelial carcinomas (LEC), we have collected 160 cases from Asian countries and Russia. All the cases examined by PCR for EBV DNA BamHI fragment and in-situ hybridization for EBER-1, EBV encoded small RNA, showed positivity for EBV infection in LEC cells, while no positive signals were found in any other salivary neoplasm examined. The incidence of LEC was highest in Guanzhou, followed by Shanghai and Chengdu and lowest in the Northern parts of China, Seoul, Niigata, and Moscow. The mean age of the patients with LEC was 43.9 years with no sex predilection. The Chinese patients were of the Han race, only including minor races. There were ninety-five cases found with LEC in the parotid gland (75{\%}), 20 in the submandibular gland (5{\%}), and 28 in the minor salivary gland (20{\%}). Histologically, the LECs were classified into two types: small nest type and large nest type. The latter type consisted of large-sized tumor cell nests and dense lymphocytic stromata and more frequently occurred in the minor salivary gland. The former consisted of small-sized tumor cell nests with fibrous and lymphocyte-depleted stromata, which were more frequently found in the parotid gland. The results indicated that EBV infection and certain geographic factors play important roles in the pathogenesis of the salivary LEC.",
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AU - Saku, Takashi

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AU - Kai, Yu Jen

AU - Tokunaga, Masayoshi

AU - Li, Jian

AU - Zhang, Weiguo

AU - Liu, Airu

AU - Wu, Lanyan

AU - Lu, Yong

AU - Zhou, Zhiyu

AU - Li, Yingfang

AU - Li, Ruyao

AU - Ouyang, Jei

AU - Yang, Lianjia

AU - Yu, Shifeng

AU - Lou, Tiecheng

AU - Wang, Suozhi

AU - Lin, Dyisheng

AU - Rao, Huilan

AU - Lin, Hanliang

AU - Sderk, Patima

AU - Chen, Zhaolun

AU - Chen, Zhirong

AU - Cai, Chonghong

AU - Kim, Hyunjung

AU - Hong, Sanpyo

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