Abstract
Epstein-Barr virus (EBV) DNA has been detected in peripheral T-cell lymphomas. In this study, analysis of the EBV termini indicated that the infection was clonal and nonpermissive. Analysis of viral expression detected the processed, spliced mRNAs representing EBNA1, LMP1, LMP2, and BamHI A transcripts in all EBV-positive peripheral T-cell lymphomas. The LMP1 protein was detected by immunofluorescence in a single specimen. In contrast, neither the EBNA2 protein nor the spliced EBNA2 mRNA were detected. These data indicate that EBV-infected T-cell lymphomas are clonal expansions of a single EBV-infected cell with a pattern of gene expression which is distinct from that detected in Burkitt's lymphomas or posttransplant lymphomas but similar to viral expression in nasopharyngeal carcinomas.
| Original language | English |
|---|---|
| Pages (from-to) | 6303-6308 |
| Number of pages | 6 |
| Journal | Journal of Virology |
| Volume | 67 |
| Issue number | 10 |
| Publication status | Published - Oct 1993 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Immunology
Cite this
Epstein-Barr Virus (EBV) gene expression in EBV-positive peripheral T-cell lymphomas. / Chen, Chi Long; Sadler, Robert H.; Walling, Dennis M.; Su, Ih Jen; Hsieh, Hong Chung; Raab-Traub, Nancy.
In: Journal of Virology, Vol. 67, No. 10, 10.1993, p. 6303-6308.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Epstein-Barr Virus (EBV) gene expression in EBV-positive peripheral T-cell lymphomas
AU - Chen, Chi Long
AU - Sadler, Robert H.
AU - Walling, Dennis M.
AU - Su, Ih Jen
AU - Hsieh, Hong Chung
AU - Raab-Traub, Nancy
PY - 1993/10
Y1 - 1993/10
N2 - Epstein-Barr virus (EBV) DNA has been detected in peripheral T-cell lymphomas. In this study, analysis of the EBV termini indicated that the infection was clonal and nonpermissive. Analysis of viral expression detected the processed, spliced mRNAs representing EBNA1, LMP1, LMP2, and BamHI A transcripts in all EBV-positive peripheral T-cell lymphomas. The LMP1 protein was detected by immunofluorescence in a single specimen. In contrast, neither the EBNA2 protein nor the spliced EBNA2 mRNA were detected. These data indicate that EBV-infected T-cell lymphomas are clonal expansions of a single EBV-infected cell with a pattern of gene expression which is distinct from that detected in Burkitt's lymphomas or posttransplant lymphomas but similar to viral expression in nasopharyngeal carcinomas.
AB - Epstein-Barr virus (EBV) DNA has been detected in peripheral T-cell lymphomas. In this study, analysis of the EBV termini indicated that the infection was clonal and nonpermissive. Analysis of viral expression detected the processed, spliced mRNAs representing EBNA1, LMP1, LMP2, and BamHI A transcripts in all EBV-positive peripheral T-cell lymphomas. The LMP1 protein was detected by immunofluorescence in a single specimen. In contrast, neither the EBNA2 protein nor the spliced EBNA2 mRNA were detected. These data indicate that EBV-infected T-cell lymphomas are clonal expansions of a single EBV-infected cell with a pattern of gene expression which is distinct from that detected in Burkitt's lymphomas or posttransplant lymphomas but similar to viral expression in nasopharyngeal carcinomas.
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UR - http://www.scopus.com/inward/citedby.url?scp=0027303682&partnerID=8YFLogxK
M3 - Article
C2 - 8396685
AN - SCOPUS:0027303682
VL - 67
SP - 6303
EP - 6308
JO - Journal of Virology
JF - Journal of Virology
SN - 0022-538X
IS - 10
ER -