Epstein-Barr virus and lymphoid hematological disorders

An Tie Hsieh, Ching Liang Ho, Yeu Chin Chen, Wei Yau Kao, Tsu Yi Chao

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background. To study the role of Epstein-Barr virus (EBV) in the carcinogenesis of various lymphoid neoplasms in Taiwan, a nonisotopic in situ hybridization (ISH) technique was used to detect the expression of EBV-encoded small RNAs (EBERs) in various lymphoid neoplasms. Methods. We obtained the paraffin-embedded tissues of various hematological malignancies from the department of Pathology, Tri-Service General Hospital. Nonisotopic ISH technique was employed to detect EBERs and immunohistochemical staining was performed to confirm the cell lineage. Results. Our data showed the frequency of EBV infection on various lymphoid malignancies as followed: Burkitt's lymphoma (BL) (10/18); non-Burkitt's Non-Hodgkin's lymphoma (3/42); non-Hodgkin's lymphoma, T cell type, nasal (NHLTN) (5/5); Hodgkin's disease (2/9); acute lymphocytic leukemia (1/24); chronic lymphocytic leukemia (1/15); and multiple myeloma (2/18). In the control group, none of the specimens from patients of acute myelocytic leukemia and myelodysplastic syndrome was positive for EBERs. Conclusions. Among the various lymphoid neoplasms we studied, only BL (p

Original languageEnglish
Pages (from-to)119-123
Number of pages5
JournalChinese Medical Journal (Taipei)
Volume65
Issue number3
Publication statusPublished - 2002
Externally publishedYes

Fingerprint

Human Herpesvirus 4
Burkitt Lymphoma
RNA
Non-Hodgkin's Lymphoma
In Situ Hybridization
Neoplasms
Epstein-Barr Virus Infections
Myelodysplastic Syndromes
Cell Lineage
Hematologic Neoplasms
B-Cell Chronic Lymphocytic Leukemia
Multiple Myeloma
Hodgkin Disease
Taiwan
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Nose
Acute Myeloid Leukemia
General Hospitals
Paraffin
Carcinogenesis

Keywords

  • EBV-encoded small RNAs
  • Epstein-Barr virus
  • In situ hybridization
  • Lymphoid neoplasm

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Hsieh, A. T., Ho, C. L., Chen, Y. C., Kao, W. Y., & Chao, T. Y. (2002). Epstein-Barr virus and lymphoid hematological disorders. Chinese Medical Journal (Taipei), 65(3), 119-123.

Epstein-Barr virus and lymphoid hematological disorders. / Hsieh, An Tie; Ho, Ching Liang; Chen, Yeu Chin; Kao, Wei Yau; Chao, Tsu Yi.

In: Chinese Medical Journal (Taipei), Vol. 65, No. 3, 2002, p. 119-123.

Research output: Contribution to journalArticle

Hsieh, AT, Ho, CL, Chen, YC, Kao, WY & Chao, TY 2002, 'Epstein-Barr virus and lymphoid hematological disorders', Chinese Medical Journal (Taipei), vol. 65, no. 3, pp. 119-123.
Hsieh, An Tie ; Ho, Ching Liang ; Chen, Yeu Chin ; Kao, Wei Yau ; Chao, Tsu Yi. / Epstein-Barr virus and lymphoid hematological disorders. In: Chinese Medical Journal (Taipei). 2002 ; Vol. 65, No. 3. pp. 119-123.
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