Epithelial origin of polyoma salivary tumors in mice: Evidence based on chromosome-marked cells

C. J. Dawe, J. Whang-Peng, W. D. Morgan, E. C. Hearon, T. Knutsen

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

Trypsin dissection of epithelium from mesenchyme of salivary gland rudiments allows reassembly of glands having either epithelium or mesenchyme selectively marked by T6 chromosomes. Virus-induced tumors in such glands invariably bear the karyotype of the epithelial component. The method solves a specific example from a group of classical problems concerning epithelial as opposed to mesenchymal origin of neoplasms.

Original languageEnglish
Pages (from-to)394-397
Number of pages4
JournalScience
Volume171
Issue number3969
Publication statusPublished - Jan 1 1971
Externally publishedYes

ASJC Scopus subject areas

  • General

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