Epithelial origin of polyoma salivary tumors in mice: Evidence based on chromosome-marked cells

C. J. Dawe, J. Whang-Peng, W. D. Morgan, E. C. Hearon, T. Knutsen

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Trypsin dissection of epithelium from mesenchyme of salivary gland rudiments allows reassembly of glands having either epithelium or mesenchyme selectively marked by T6 chromosomes. Virus-induced tumors in such glands invariably bear the karyotype of the epithelial component. The method solves a specific example from a group of classical problems concerning epithelial as opposed to mesenchymal origin of neoplasms.

Original languageEnglish
Pages (from-to)394-397
Number of pages4
JournalScience
Volume171
Issue number3969
Publication statusPublished - Jan 1 1971
Externally publishedYes

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    Dawe, C. J., Whang-Peng, J., Morgan, W. D., Hearon, E. C., & Knutsen, T. (1971). Epithelial origin of polyoma salivary tumors in mice: Evidence based on chromosome-marked cells. Science, 171(3969), 394-397.