Epileptic seizure in primary intracranial sarcoma: a case report and literature review

Yen Ping Chen, Hsiu Fen Lee, Tai-Tong Wong

Research output: Contribution to journalArticle


Purpose: The aim of this study is to describe epileptic seizures in patients with primary intracranial sarcomas. Methods: We report a 17-year-old girl diagnosed with primary high-grade intracranial sarcoma with initial clinical manifestation of nonconvulsive status epilepticus. Literature reports between 2000 and 2014, relevant to primary intracranial sarcomas in children, were reviewed. The clinical presentations and neurological outcomes were analyzed. Results: Eleven of 29cases (38 %), 8 males and 3 females, who exhibited epileptic seizures as one of the initial symptoms and diagnosed with primary intracranial sarcomas were collected. The median age of disease onset was 5 years. The two most common seizure types were generalized seizures (45 %) and status epilepticus (36 %). Nine of 11 patients (82 %) had tumor growth involving the frontal lobe. Nine cases had the median duration of follow-up 1.7 years, of which 6 cases showed tumor recurrence and 3 cases died during the period of follow-up. Conclusions: Epileptic seizures as one of the clinical manifestations are uncommon. The two most common seizure types were generalized seizures and status epilepticus. The most frequent location of primary intracranial sarcoma-related seizures was the frontal lobe. The clinical outcome varied.

Original languageEnglish
Pages (from-to)1709-1714
Number of pages6
JournalChild's Nervous System
Issue number9
Publication statusPublished - Sep 1 2016



  • Child
  • Clinical manifestations
  • Clinical outcomes
  • Epileptic seizures
  • Intracranial sarcoma

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

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