Epigenetics in asthma and other inflammatory lung diseases

Andrew Durham, Pai Chien Chou, Paul Kirkham, Ian M. Adcock

Research output: Contribution to journalReview article

18 Citations (Scopus)

Abstract

Asthma is a chronic inflammatory disease of the airways. The causes of asthma and other inflammatory lung diseases are thought to be both environmental and heritable. Genetic studies do not adequately explain the heritability and susceptabilty to the disease, and recent evidence suggests that epigentic changes may underlie these processes. Epigenetics are heritable noncoding changes to DNA and can be influenced by environmental factors such as smoking and traffic pollution, which can cause genome-wide and gene-specific changes in DNA methylation. In addition, alterations in histone acetyltransferase/ deacetylase activities can be observed in the cells of patients with lung diseases such as severe asthma and chronic obstructive pulmonary disease, and are often linked to smoking. Drugs such as glucocorticoids, which are used to control inflammation, are dependent on histone deacetylase activity, which may be important in patients with severe asthma and chronic obstructive pulmonary disease who do not respond well to glucocorticoid therapy. Future work targeting specific histone acetyltransferases/deacetylases or (de)methylases may prove to be effective future anti-inflammatory treatments for patients with treatment-unresponsive asthma.

Original languageEnglish
Pages (from-to)523-537
Number of pages15
JournalEpigenomics
Volume2
Issue number4
DOIs
Publication statusPublished - Aug 1 2010
Externally publishedYes

Fingerprint

Epigenomics
Lung Diseases
Asthma
Histone Deacetylases
Histone Acetyltransferases
Chronic Obstructive Pulmonary Disease
Glucocorticoids
Smoking
DNA Methylation
Chronic Disease
Anti-Inflammatory Agents
Therapeutics
Genome
Inflammation
DNA
Pharmaceutical Preparations
Genes

Keywords

  • chronic obstructive pulmonary disease
  • epigenetics
  • histone deacetylase
  • inflammation

ASJC Scopus subject areas

  • Genetics
  • Cancer Research

Cite this

Epigenetics in asthma and other inflammatory lung diseases. / Durham, Andrew; Chou, Pai Chien; Kirkham, Paul; Adcock, Ian M.

In: Epigenomics, Vol. 2, No. 4, 01.08.2010, p. 523-537.

Research output: Contribution to journalReview article

Durham, A, Chou, PC, Kirkham, P & Adcock, IM 2010, 'Epigenetics in asthma and other inflammatory lung diseases', Epigenomics, vol. 2, no. 4, pp. 523-537. https://doi.org/10.2217/epi.10.27
Durham, Andrew ; Chou, Pai Chien ; Kirkham, Paul ; Adcock, Ian M. / Epigenetics in asthma and other inflammatory lung diseases. In: Epigenomics. 2010 ; Vol. 2, No. 4. pp. 523-537.
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