Epidemiology and antimicrobial susceptibility profiles of pathogens causing urinary tract infections in the Asia-Pacific region: Results from the Study for Monitoring Antimicrobial Resistance Trends (SMART), 2010-2013

Shio Shin Jean, Geoffrey Coombs, Thomas Ling, V. Balaji, Camilla Rodrigues, Hiroshige Mikamo, Min Ja Kim, Datin Ganeswrie Rajasekaram, Myrna Mendoza, Thean Yen Tan, Pattarachai Kiratisin, Yuxing Ni, Bary Weinman, Yingchun Xu, Po Ren Hsueh

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Abstract

A total of 9599 isolates of Gram-negative bacteria (GNB) causing urinary tract infections (UTIs) were collected from 60 centres in 13 countries in the Asia-Pacific region from 2010-2013. These isolates comprised Enterobacteriaceae species (mainly Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Klebsiella oxytoca, Enterobacter cloacae and Morganella morganii) and non-fermentative GNB species (predominantly Pseudomonas aeruginosa and Acinetobacter baumannii). In vitro susceptibilities were determined by the agar dilution method and susceptibility profiles were determined using the minimum inhibitory concentration (MIC) interpretive breakpoints recommended by the Clinical and Laboratory Standards Institute in 2015. Production of extended-spectrum β-lactamases (ESBLs) amongst E. coli, K. pneumoniae, P. mirabilis and K. oxytoca isolates was determined by the double-disk synergy test. China, Vietnam, India, Thailand and the Philippines had the highest rates of GNB species producing ESBLs and the highest rates of cephalosporin resistance. ESBL production and hospital-acquired infection (isolates obtained ≥48. h after admission) significantly compromised the susceptibility of isolates of E. coli and K. pneumoniae to ciprofloxacin, levofloxacin and most β-lactams, with the exception of imipenem and ertapenem. However, >87% of ESBL-producing E. coli strains were susceptible to amikacin and piperacillin/tazobactam, indicating that these antibiotics might be appropriate alternatives for treating UTIs due to ESBL-producing E. coli. Fluoroquinolones were shown to be inappropriate as empirical therapy for UTIs. Antibiotic resistance is a serious problem in the Asia-Pacific region. Therefore, continuous monitoring of evolutionary trends in the susceptibility profiles of GNB causing UTIs in Asia is crucial.

Original languageEnglish
JournalInternational Journal of Antimicrobial Agents
DOIs
Publication statusAccepted/In press - Nov 25 2015

Fingerprint

Urinary Tract Infections
Epidemiology
Gram-Negative Bacteria
Escherichia coli
Klebsiella pneumoniae
Klebsiella oxytoca
Proteus mirabilis
Cephalosporin Resistance
Morganella morganii
Enterobacter cloacae
Acinetobacter baumannii
Lactams
Levofloxacin
Philippines
Amikacin
Imipenem
Vietnam
Fluoroquinolones
Microbial Sensitivity Tests
Enterobacteriaceae

Keywords

  • ESBL
  • Extended-spectrum β-lactamase
  • Gram-negative bacteria
  • Hospital-acquired
  • Susceptibility
  • Urinary tract infection

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)

Cite this

Epidemiology and antimicrobial susceptibility profiles of pathogens causing urinary tract infections in the Asia-Pacific region : Results from the Study for Monitoring Antimicrobial Resistance Trends (SMART), 2010-2013. / Jean, Shio Shin; Coombs, Geoffrey; Ling, Thomas; Balaji, V.; Rodrigues, Camilla; Mikamo, Hiroshige; Kim, Min Ja; Rajasekaram, Datin Ganeswrie; Mendoza, Myrna; Tan, Thean Yen; Kiratisin, Pattarachai; Ni, Yuxing; Weinman, Bary; Xu, Yingchun; Hsueh, Po Ren.

In: International Journal of Antimicrobial Agents, 25.11.2015.

Research output: Contribution to journalArticle

Jean, Shio Shin ; Coombs, Geoffrey ; Ling, Thomas ; Balaji, V. ; Rodrigues, Camilla ; Mikamo, Hiroshige ; Kim, Min Ja ; Rajasekaram, Datin Ganeswrie ; Mendoza, Myrna ; Tan, Thean Yen ; Kiratisin, Pattarachai ; Ni, Yuxing ; Weinman, Bary ; Xu, Yingchun ; Hsueh, Po Ren. / Epidemiology and antimicrobial susceptibility profiles of pathogens causing urinary tract infections in the Asia-Pacific region : Results from the Study for Monitoring Antimicrobial Resistance Trends (SMART), 2010-2013. In: International Journal of Antimicrobial Agents. 2015.
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abstract = "A total of 9599 isolates of Gram-negative bacteria (GNB) causing urinary tract infections (UTIs) were collected from 60 centres in 13 countries in the Asia-Pacific region from 2010-2013. These isolates comprised Enterobacteriaceae species (mainly Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Klebsiella oxytoca, Enterobacter cloacae and Morganella morganii) and non-fermentative GNB species (predominantly Pseudomonas aeruginosa and Acinetobacter baumannii). In vitro susceptibilities were determined by the agar dilution method and susceptibility profiles were determined using the minimum inhibitory concentration (MIC) interpretive breakpoints recommended by the Clinical and Laboratory Standards Institute in 2015. Production of extended-spectrum β-lactamases (ESBLs) amongst E. coli, K. pneumoniae, P. mirabilis and K. oxytoca isolates was determined by the double-disk synergy test. China, Vietnam, India, Thailand and the Philippines had the highest rates of GNB species producing ESBLs and the highest rates of cephalosporin resistance. ESBL production and hospital-acquired infection (isolates obtained ≥48. h after admission) significantly compromised the susceptibility of isolates of E. coli and K. pneumoniae to ciprofloxacin, levofloxacin and most β-lactams, with the exception of imipenem and ertapenem. However, >87{\%} of ESBL-producing E. coli strains were susceptible to amikacin and piperacillin/tazobactam, indicating that these antibiotics might be appropriate alternatives for treating UTIs due to ESBL-producing E. coli. Fluoroquinolones were shown to be inappropriate as empirical therapy for UTIs. Antibiotic resistance is a serious problem in the Asia-Pacific region. Therefore, continuous monitoring of evolutionary trends in the susceptibility profiles of GNB causing UTIs in Asia is crucial.",
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