Epidemiologic relationship between fluoroquinolone-resistant Salmonella enterica serovar choleraesuis strains isolated from humans and pigs in Taiwan (1997 to 2002)

Chao Chin Chang, Yi Hsuan Lin, Chao Fu Chang, Kuang Sheng Yeh, Cheng Hsun Chiu, Chishih Chu, Maw Sheng Chien, Yuan Man Hsu, Li Shu Tsai, Chien Shun Chiou

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Abstract

The emergence of ciprofloxacin-resistant Salmonella enterica serovar Choleraesuis in recent years has become an important public health issue in Taiwan. The resistant strains that cause human infections are considered to be from pigs. In this study, we characterized 157 swine and 42 human Salmonella serovar Choleraesuis isolates by pulsed-field gel electrophoresis (PFGE) and drug susceptibility testing to investigate the epidemiologic relationship among the isolates. By PFGE analyses, two major clusters (clusters GA and GB) were identified. Isolates in cluster GA were of both human and swine origins, while those in cluster GB were from pigs only. Among the various genotypes identified, genotype gt-la was the most prevalent, which was found in 71% (30 of 42) and 48% (76 of 157) of human and swine isolates, respectively. The susceptibility tests for the 106 gt-1a isolates identified 44 susceptibility profiles and showed that 73% of human isolates and 34% of swine isolates were resistant to three fluoroquinolones (ciprofloxacin, enrofloxacin, and norfloxacin). Our findings indicate that a clonal group of Salmonella serovar Choleraesuis may have been circulating in human and swine populations in Taiwan for years and that the fluoroquinolone-resistant Salmonella serovar Choleraesuis strains most likely evolved from a gt-1a clone that emerged in 2000 and that then caused widespread infections in humans and pigs. Nevertheless, it is still debatable whether those Salmonella infections in humans are caused by isolates derived from pigs, on the basis of the higher fluoroquinolone and other antimicrobial resistance percentages in human isolates than in pig isolates.

Original languageEnglish
Pages (from-to)2798-2804
Number of pages7
JournalJournal of Clinical Microbiology
Volume43
Issue number6
DOIs
Publication statusPublished - Jun 2005

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Salmonella enterica
Fluoroquinolones
Taiwan
Swine
Salmonella
Pulsed Field Gel Electrophoresis
Ciprofloxacin
Genotype
Serogroup
Norfloxacin
Salmonella Infections
Infection
Public Health
Clone Cells

ASJC Scopus subject areas

  • Microbiology (medical)
  • Microbiology

Cite this

Epidemiologic relationship between fluoroquinolone-resistant Salmonella enterica serovar choleraesuis strains isolated from humans and pigs in Taiwan (1997 to 2002). / Chang, Chao Chin; Lin, Yi Hsuan; Chang, Chao Fu; Yeh, Kuang Sheng; Chiu, Cheng Hsun; Chu, Chishih; Chien, Maw Sheng; Hsu, Yuan Man; Tsai, Li Shu; Chiou, Chien Shun.

In: Journal of Clinical Microbiology, Vol. 43, No. 6, 06.2005, p. 2798-2804.

Research output: Contribution to journalArticle

Chang, Chao Chin ; Lin, Yi Hsuan ; Chang, Chao Fu ; Yeh, Kuang Sheng ; Chiu, Cheng Hsun ; Chu, Chishih ; Chien, Maw Sheng ; Hsu, Yuan Man ; Tsai, Li Shu ; Chiou, Chien Shun. / Epidemiologic relationship between fluoroquinolone-resistant Salmonella enterica serovar choleraesuis strains isolated from humans and pigs in Taiwan (1997 to 2002). In: Journal of Clinical Microbiology. 2005 ; Vol. 43, No. 6. pp. 2798-2804.
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abstract = "The emergence of ciprofloxacin-resistant Salmonella enterica serovar Choleraesuis in recent years has become an important public health issue in Taiwan. The resistant strains that cause human infections are considered to be from pigs. In this study, we characterized 157 swine and 42 human Salmonella serovar Choleraesuis isolates by pulsed-field gel electrophoresis (PFGE) and drug susceptibility testing to investigate the epidemiologic relationship among the isolates. By PFGE analyses, two major clusters (clusters GA and GB) were identified. Isolates in cluster GA were of both human and swine origins, while those in cluster GB were from pigs only. Among the various genotypes identified, genotype gt-la was the most prevalent, which was found in 71{\%} (30 of 42) and 48{\%} (76 of 157) of human and swine isolates, respectively. The susceptibility tests for the 106 gt-1a isolates identified 44 susceptibility profiles and showed that 73{\%} of human isolates and 34{\%} of swine isolates were resistant to three fluoroquinolones (ciprofloxacin, enrofloxacin, and norfloxacin). Our findings indicate that a clonal group of Salmonella serovar Choleraesuis may have been circulating in human and swine populations in Taiwan for years and that the fluoroquinolone-resistant Salmonella serovar Choleraesuis strains most likely evolved from a gt-1a clone that emerged in 2000 and that then caused widespread infections in humans and pigs. Nevertheless, it is still debatable whether those Salmonella infections in humans are caused by isolates derived from pigs, on the basis of the higher fluoroquinolone and other antimicrobial resistance percentages in human isolates than in pig isolates.",
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AU - Chang, Chao Chin

AU - Lin, Yi Hsuan

AU - Chang, Chao Fu

AU - Yeh, Kuang Sheng

AU - Chiu, Cheng Hsun

AU - Chu, Chishih

AU - Chien, Maw Sheng

AU - Hsu, Yuan Man

AU - Tsai, Li Shu

AU - Chiou, Chien Shun

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N2 - The emergence of ciprofloxacin-resistant Salmonella enterica serovar Choleraesuis in recent years has become an important public health issue in Taiwan. The resistant strains that cause human infections are considered to be from pigs. In this study, we characterized 157 swine and 42 human Salmonella serovar Choleraesuis isolates by pulsed-field gel electrophoresis (PFGE) and drug susceptibility testing to investigate the epidemiologic relationship among the isolates. By PFGE analyses, two major clusters (clusters GA and GB) were identified. Isolates in cluster GA were of both human and swine origins, while those in cluster GB were from pigs only. Among the various genotypes identified, genotype gt-la was the most prevalent, which was found in 71% (30 of 42) and 48% (76 of 157) of human and swine isolates, respectively. The susceptibility tests for the 106 gt-1a isolates identified 44 susceptibility profiles and showed that 73% of human isolates and 34% of swine isolates were resistant to three fluoroquinolones (ciprofloxacin, enrofloxacin, and norfloxacin). Our findings indicate that a clonal group of Salmonella serovar Choleraesuis may have been circulating in human and swine populations in Taiwan for years and that the fluoroquinolone-resistant Salmonella serovar Choleraesuis strains most likely evolved from a gt-1a clone that emerged in 2000 and that then caused widespread infections in humans and pigs. Nevertheless, it is still debatable whether those Salmonella infections in humans are caused by isolates derived from pigs, on the basis of the higher fluoroquinolone and other antimicrobial resistance percentages in human isolates than in pig isolates.

AB - The emergence of ciprofloxacin-resistant Salmonella enterica serovar Choleraesuis in recent years has become an important public health issue in Taiwan. The resistant strains that cause human infections are considered to be from pigs. In this study, we characterized 157 swine and 42 human Salmonella serovar Choleraesuis isolates by pulsed-field gel electrophoresis (PFGE) and drug susceptibility testing to investigate the epidemiologic relationship among the isolates. By PFGE analyses, two major clusters (clusters GA and GB) were identified. Isolates in cluster GA were of both human and swine origins, while those in cluster GB were from pigs only. Among the various genotypes identified, genotype gt-la was the most prevalent, which was found in 71% (30 of 42) and 48% (76 of 157) of human and swine isolates, respectively. The susceptibility tests for the 106 gt-1a isolates identified 44 susceptibility profiles and showed that 73% of human isolates and 34% of swine isolates were resistant to three fluoroquinolones (ciprofloxacin, enrofloxacin, and norfloxacin). Our findings indicate that a clonal group of Salmonella serovar Choleraesuis may have been circulating in human and swine populations in Taiwan for years and that the fluoroquinolone-resistant Salmonella serovar Choleraesuis strains most likely evolved from a gt-1a clone that emerged in 2000 and that then caused widespread infections in humans and pigs. Nevertheless, it is still debatable whether those Salmonella infections in humans are caused by isolates derived from pigs, on the basis of the higher fluoroquinolone and other antimicrobial resistance percentages in human isolates than in pig isolates.

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