Epidemiologic features of Kawasaki disease in Taiwan, 1996-2002

Luan Yin Chang, I. Shou Chang, Chun Yi Lu, Bor Luen Chiang, Chin Yun Lee, Pei Jer Chen, Jin Town Wang, Hong Nerng Ho, Ding Shinn Chen, Li Min Huang

Research output: Contribution to journalArticle

80 Citations (Scopus)

Abstract

Objective. Kawasaki disease (KD) is the most common acquired heart disease in children worldwide. The incidence of KD varies among different countries, with Asian countries supposedly having higher incidences than Western countries. However, the incidence of KD in Taiwan has not been well investigated. Methods. Since the implementation of Taiwan's National Health Insurance (NHI) in 1995, NHI has covered health care for >96% its population. Using the NHI database from 1996 to 2002, we investigated epidemiologic features of KD (International Classification of Diseases, Ninth Revision, code 446.1), the rate of coronary artery aneurysm formation (International Classification of Diseases, Ninth Revision, code 414.11), and the change in incidence during the recent 7 years. We also compared the annual incidences in Taiwan with those reported by other countries. Results. During the 7-year study period, KD occurred most frequently in the summer and least frequently in winter. It is interesting that the highest peak occurred in the summer of 1998 at the same time that Taiwan's enterovirus 71 epidemic was occurring. Ninety-one percent of KD cases occurred in children who were <5 years old, and the male-to-female ratio was 1.70:1. Recurrence of KD was found in 1.3% (94 of 7305) of these children, and coronary artery aneurysm was found in 7.3% (536 of 7305). The annual incidence per 100 000 children was 146 in children <1 year old, 98 in 1-year-old children, 51 in 2-year-old children, 28 in 3-year-old children, 19 in 4-year-old children, and 5.3 in 5- to 9-year-old children; the incidence of KD decreased with increased age. The overall incidence was 66 cases per 100 000 children <5 years old from 1996 to 2002 with the annual incidence not differing significantly during the 7-year study period. Conclusions. KD in Taiwan occurs more frequently in boys and in the summer months. During the 7-year study period, the annual KD incidence in Taiwan of 66/100000 in children <5 years old was the second highest in the world after Japan.

Original languageEnglish
JournalPediatrics
Volume114
Issue number6
DOIs
Publication statusPublished - Jan 1 2004
Externally publishedYes

Keywords

  • Age distribution
  • Annual incidence
  • Kawasaki disease
  • Season

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Chang, L. Y., Chang, I. S., Lu, C. Y., Chiang, B. L., Lee, C. Y., Chen, P. J., ... Huang, L. M. (2004). Epidemiologic features of Kawasaki disease in Taiwan, 1996-2002. Pediatrics, 114(6). https://doi.org/10.1542/peds.2004-0726

Epidemiologic features of Kawasaki disease in Taiwan, 1996-2002. / Chang, Luan Yin; Chang, I. Shou; Lu, Chun Yi; Chiang, Bor Luen; Lee, Chin Yun; Chen, Pei Jer; Wang, Jin Town; Ho, Hong Nerng; Chen, Ding Shinn; Huang, Li Min.

In: Pediatrics, Vol. 114, No. 6, 01.01.2004.

Research output: Contribution to journalArticle

Chang, LY, Chang, IS, Lu, CY, Chiang, BL, Lee, CY, Chen, PJ, Wang, JT, Ho, HN, Chen, DS & Huang, LM 2004, 'Epidemiologic features of Kawasaki disease in Taiwan, 1996-2002', Pediatrics, vol. 114, no. 6. https://doi.org/10.1542/peds.2004-0726
Chang LY, Chang IS, Lu CY, Chiang BL, Lee CY, Chen PJ et al. Epidemiologic features of Kawasaki disease in Taiwan, 1996-2002. Pediatrics. 2004 Jan 1;114(6). https://doi.org/10.1542/peds.2004-0726
Chang, Luan Yin ; Chang, I. Shou ; Lu, Chun Yi ; Chiang, Bor Luen ; Lee, Chin Yun ; Chen, Pei Jer ; Wang, Jin Town ; Ho, Hong Nerng ; Chen, Ding Shinn ; Huang, Li Min. / Epidemiologic features of Kawasaki disease in Taiwan, 1996-2002. In: Pediatrics. 2004 ; Vol. 114, No. 6.
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abstract = "Objective. Kawasaki disease (KD) is the most common acquired heart disease in children worldwide. The incidence of KD varies among different countries, with Asian countries supposedly having higher incidences than Western countries. However, the incidence of KD in Taiwan has not been well investigated. Methods. Since the implementation of Taiwan's National Health Insurance (NHI) in 1995, NHI has covered health care for >96{\%} its population. Using the NHI database from 1996 to 2002, we investigated epidemiologic features of KD (International Classification of Diseases, Ninth Revision, code 446.1), the rate of coronary artery aneurysm formation (International Classification of Diseases, Ninth Revision, code 414.11), and the change in incidence during the recent 7 years. We also compared the annual incidences in Taiwan with those reported by other countries. Results. During the 7-year study period, KD occurred most frequently in the summer and least frequently in winter. It is interesting that the highest peak occurred in the summer of 1998 at the same time that Taiwan's enterovirus 71 epidemic was occurring. Ninety-one percent of KD cases occurred in children who were <5 years old, and the male-to-female ratio was 1.70:1. Recurrence of KD was found in 1.3{\%} (94 of 7305) of these children, and coronary artery aneurysm was found in 7.3{\%} (536 of 7305). The annual incidence per 100 000 children was 146 in children <1 year old, 98 in 1-year-old children, 51 in 2-year-old children, 28 in 3-year-old children, 19 in 4-year-old children, and 5.3 in 5- to 9-year-old children; the incidence of KD decreased with increased age. The overall incidence was 66 cases per 100 000 children <5 years old from 1996 to 2002 with the annual incidence not differing significantly during the 7-year study period. Conclusions. KD in Taiwan occurs more frequently in boys and in the summer months. During the 7-year study period, the annual KD incidence in Taiwan of 66/100000 in children <5 years old was the second highest in the world after Japan.",
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AU - Chang, Luan Yin

AU - Chang, I. Shou

AU - Lu, Chun Yi

AU - Chiang, Bor Luen

AU - Lee, Chin Yun

AU - Chen, Pei Jer

AU - Wang, Jin Town

AU - Ho, Hong Nerng

AU - Chen, Ding Shinn

AU - Huang, Li Min

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N2 - Objective. Kawasaki disease (KD) is the most common acquired heart disease in children worldwide. The incidence of KD varies among different countries, with Asian countries supposedly having higher incidences than Western countries. However, the incidence of KD in Taiwan has not been well investigated. Methods. Since the implementation of Taiwan's National Health Insurance (NHI) in 1995, NHI has covered health care for >96% its population. Using the NHI database from 1996 to 2002, we investigated epidemiologic features of KD (International Classification of Diseases, Ninth Revision, code 446.1), the rate of coronary artery aneurysm formation (International Classification of Diseases, Ninth Revision, code 414.11), and the change in incidence during the recent 7 years. We also compared the annual incidences in Taiwan with those reported by other countries. Results. During the 7-year study period, KD occurred most frequently in the summer and least frequently in winter. It is interesting that the highest peak occurred in the summer of 1998 at the same time that Taiwan's enterovirus 71 epidemic was occurring. Ninety-one percent of KD cases occurred in children who were <5 years old, and the male-to-female ratio was 1.70:1. Recurrence of KD was found in 1.3% (94 of 7305) of these children, and coronary artery aneurysm was found in 7.3% (536 of 7305). The annual incidence per 100 000 children was 146 in children <1 year old, 98 in 1-year-old children, 51 in 2-year-old children, 28 in 3-year-old children, 19 in 4-year-old children, and 5.3 in 5- to 9-year-old children; the incidence of KD decreased with increased age. The overall incidence was 66 cases per 100 000 children <5 years old from 1996 to 2002 with the annual incidence not differing significantly during the 7-year study period. Conclusions. KD in Taiwan occurs more frequently in boys and in the summer months. During the 7-year study period, the annual KD incidence in Taiwan of 66/100000 in children <5 years old was the second highest in the world after Japan.

AB - Objective. Kawasaki disease (KD) is the most common acquired heart disease in children worldwide. The incidence of KD varies among different countries, with Asian countries supposedly having higher incidences than Western countries. However, the incidence of KD in Taiwan has not been well investigated. Methods. Since the implementation of Taiwan's National Health Insurance (NHI) in 1995, NHI has covered health care for >96% its population. Using the NHI database from 1996 to 2002, we investigated epidemiologic features of KD (International Classification of Diseases, Ninth Revision, code 446.1), the rate of coronary artery aneurysm formation (International Classification of Diseases, Ninth Revision, code 414.11), and the change in incidence during the recent 7 years. We also compared the annual incidences in Taiwan with those reported by other countries. Results. During the 7-year study period, KD occurred most frequently in the summer and least frequently in winter. It is interesting that the highest peak occurred in the summer of 1998 at the same time that Taiwan's enterovirus 71 epidemic was occurring. Ninety-one percent of KD cases occurred in children who were <5 years old, and the male-to-female ratio was 1.70:1. Recurrence of KD was found in 1.3% (94 of 7305) of these children, and coronary artery aneurysm was found in 7.3% (536 of 7305). The annual incidence per 100 000 children was 146 in children <1 year old, 98 in 1-year-old children, 51 in 2-year-old children, 28 in 3-year-old children, 19 in 4-year-old children, and 5.3 in 5- to 9-year-old children; the incidence of KD decreased with increased age. The overall incidence was 66 cases per 100 000 children <5 years old from 1996 to 2002 with the annual incidence not differing significantly during the 7-year study period. Conclusions. KD in Taiwan occurs more frequently in boys and in the summer months. During the 7-year study period, the annual KD incidence in Taiwan of 66/100000 in children <5 years old was the second highest in the world after Japan.

KW - Age distribution

KW - Annual incidence

KW - Kawasaki disease

KW - Season

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