Epidemiologic evidence of diabetogenic effect of arsenic

Chin Hsiao Tseng, Ching Ping Tseng, Hung Yi Chiou, Yu Mei Hsueh, Choon Khim Chong, Chien Jen Chen

Research output: Contribution to journalArticle

116 Citations (Scopus)

Abstract

It is well documented that arsenic can lead to skin lesions, atherosclerotic diseases and cancers. The association between arsenic exposure and diabetes mellitus is a relatively new finding. Up to now, there are six epidemiologic reports linking diabetes mellitus with arsenic exposure from environmental and occupational sources. Two reports in Taiwan carried out in the blackfoot disease-hyperendemic villages, one cross-sectional and one prospective follow-up of the same cohort, indicate that arsenic exposure from drinking artesian well water is associated with prevalence and incidence of diabetes mellitus in a dose-responsive pattern. The observation of the relation between arsenic exposure and diabetes mellitus is further supported by studies carried out in Sweden and Bangladesh. In Sweden, case-control analyses of death records of copper smelters and glass workers revealed a trend of increasing diabetes mellitus with increasing arsenic exposure from inhalation. In Bangladesh, prevalence of diabetes mellitus among arsenic-exposed subjects with keratosis was about five times higher than unexposed subjects. Increasing trends of diabetes mellitus with indices of arsenic exposure in drinking water seems to be independent of the presence of skin lesions associated with arsenic exposure. Although these studies consistently show an association between arsenic exposure and diabetes mellitus, the weak study designs of cross-sectional or case-control, the use of glucosuria or diabetes death as diagnostic criteria and the lack of adjustment for possible confounders in some studies, are major limitations that may reduce the strength of the evidence.

Original languageEnglish
Pages (from-to)69-76
Number of pages8
JournalToxicology Letters
Volume133
Issue number1
DOIs
Publication statusPublished - Jul 7 2002

Fingerprint

Arsenic
Medical problems
Diabetes Mellitus
Bangladesh
Sweden
Skin
Water Wells
Keratosis
Inhalation Exposure
Death Certificates
Environmental Exposure
Occupational Exposure
Taiwan
Drinking Water
Drinking
Glass
Copper
Cross-Sectional Studies
Observation
Water

Keywords

  • Arsenic
  • Diabetes mellitus
  • Epidemiology
  • Occupational exposure
  • Water pollutant

ASJC Scopus subject areas

  • Toxicology

Cite this

Epidemiologic evidence of diabetogenic effect of arsenic. / Tseng, Chin Hsiao; Tseng, Ching Ping; Chiou, Hung Yi; Hsueh, Yu Mei; Chong, Choon Khim; Chen, Chien Jen.

In: Toxicology Letters, Vol. 133, No. 1, 07.07.2002, p. 69-76.

Research output: Contribution to journalArticle

Tseng, Chin Hsiao ; Tseng, Ching Ping ; Chiou, Hung Yi ; Hsueh, Yu Mei ; Chong, Choon Khim ; Chen, Chien Jen. / Epidemiologic evidence of diabetogenic effect of arsenic. In: Toxicology Letters. 2002 ; Vol. 133, No. 1. pp. 69-76.
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