Epicardial Adipose Tissue Thickness and Ablation Outcome of Atrial Fibrillation

Tze Fan Chao, Chung Lieh Hung, Hsuan Ming Tsao, Yenn Jiang Lin, Chun Ho Yun, Yau Huei Lai, Shih Lin Chang, Li Wei Lo, Yu Feng Hu, Ta Chuan Tuan, Hung Yu Chang, Jen Yuan Kuo, Hung I. Yeh, Tsu Juey Wu, Ming Hsiung Hsieh, Wen Chung Yu, Shih Ann Chen

Research output: Contribution to journalArticle

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Abstract

Objectives:Epicardial fat was closely related to atrial fibrillation (AF). Transthoracic echocardiography (TTE) has been proposed to be a convenient imaging tool in assessing epicardial adipose tissue (EAT). The goal of the present study was to investigate whether the EAT thickness measured on TTE was a useful parameter in predicting procedural outcomes of AF ablations.Methods and Results:A total of 227 paroxysmal AF (PAF) and 56 non-paroxysmal AF (non-PAF) patients receiving catheter ablations from 2008-2010 were enrolled. Echocardiography-derived regional EAT thickness from parasternal long-axis view was quantified for each patient. Free of recurrence was defined as the absence of atrial arrhythmias without using antiarrhythmic agents after ablations. The mean EAT thickness of the study population was 6.1 ± 0.8 mm. Non-PAF patients had a thicker EAT than that of PAF patients (7.0 ± 0.7 mm versus 5.9 ± 0.7 mm, p value 2 score, left atrial diameter and EAT thickness were independent predictors of recurrence after catheter ablations. At a cutoff value of 6 mm for PAF and 6.9 mm for non-PAF, the measurement of EAT thickness could help us to identify patients at risk of recurrences.Conclusions:EAT thickness may serve as a useful parameter in predicting recurrences after AF ablations. Compared to other imaging modalities, TTE can be an alternative choice with less cost and time in assessing the effects of EAT on ablation outcomes.

Original languageEnglish
Article numbere74926
JournalPLoS One
Volume8
Issue number9
DOIs
Publication statusPublished - Sep 16 2013

Fingerprint

Ablation
Atrial Fibrillation
adipose tissue
Adipose Tissue
Tissue
Echocardiography
echocardiography
Recurrence
Catheter Ablation
Catheters
catheters
myocardial depressants
image analysis
Imaging techniques
atrial fibrillation
arrhythmia
Cardiac Arrhythmias
Fats
Costs and Cost Analysis
lipids

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Chao, T. F., Hung, C. L., Tsao, H. M., Lin, Y. J., Yun, C. H., Lai, Y. H., ... Chen, S. A. (2013). Epicardial Adipose Tissue Thickness and Ablation Outcome of Atrial Fibrillation. PLoS One, 8(9), [e74926]. https://doi.org/10.1371/journal.pone.0074926

Epicardial Adipose Tissue Thickness and Ablation Outcome of Atrial Fibrillation. / Chao, Tze Fan; Hung, Chung Lieh; Tsao, Hsuan Ming; Lin, Yenn Jiang; Yun, Chun Ho; Lai, Yau Huei; Chang, Shih Lin; Lo, Li Wei; Hu, Yu Feng; Tuan, Ta Chuan; Chang, Hung Yu; Kuo, Jen Yuan; Yeh, Hung I.; Wu, Tsu Juey; Hsieh, Ming Hsiung; Yu, Wen Chung; Chen, Shih Ann.

In: PLoS One, Vol. 8, No. 9, e74926, 16.09.2013.

Research output: Contribution to journalArticle

Chao, TF, Hung, CL, Tsao, HM, Lin, YJ, Yun, CH, Lai, YH, Chang, SL, Lo, LW, Hu, YF, Tuan, TC, Chang, HY, Kuo, JY, Yeh, HI, Wu, TJ, Hsieh, MH, Yu, WC & Chen, SA 2013, 'Epicardial Adipose Tissue Thickness and Ablation Outcome of Atrial Fibrillation', PLoS One, vol. 8, no. 9, e74926. https://doi.org/10.1371/journal.pone.0074926
Chao, Tze Fan ; Hung, Chung Lieh ; Tsao, Hsuan Ming ; Lin, Yenn Jiang ; Yun, Chun Ho ; Lai, Yau Huei ; Chang, Shih Lin ; Lo, Li Wei ; Hu, Yu Feng ; Tuan, Ta Chuan ; Chang, Hung Yu ; Kuo, Jen Yuan ; Yeh, Hung I. ; Wu, Tsu Juey ; Hsieh, Ming Hsiung ; Yu, Wen Chung ; Chen, Shih Ann. / Epicardial Adipose Tissue Thickness and Ablation Outcome of Atrial Fibrillation. In: PLoS One. 2013 ; Vol. 8, No. 9.
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abstract = "Objectives:Epicardial fat was closely related to atrial fibrillation (AF). Transthoracic echocardiography (TTE) has been proposed to be a convenient imaging tool in assessing epicardial adipose tissue (EAT). The goal of the present study was to investigate whether the EAT thickness measured on TTE was a useful parameter in predicting procedural outcomes of AF ablations.Methods and Results:A total of 227 paroxysmal AF (PAF) and 56 non-paroxysmal AF (non-PAF) patients receiving catheter ablations from 2008-2010 were enrolled. Echocardiography-derived regional EAT thickness from parasternal long-axis view was quantified for each patient. Free of recurrence was defined as the absence of atrial arrhythmias without using antiarrhythmic agents after ablations. The mean EAT thickness of the study population was 6.1 ± 0.8 mm. Non-PAF patients had a thicker EAT than that of PAF patients (7.0 ± 0.7 mm versus 5.9 ± 0.7 mm, p value 2 score, left atrial diameter and EAT thickness were independent predictors of recurrence after catheter ablations. At a cutoff value of 6 mm for PAF and 6.9 mm for non-PAF, the measurement of EAT thickness could help us to identify patients at risk of recurrences.Conclusions:EAT thickness may serve as a useful parameter in predicting recurrences after AF ablations. Compared to other imaging modalities, TTE can be an alternative choice with less cost and time in assessing the effects of EAT on ablation outcomes.",
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AU - Chao, Tze Fan

AU - Hung, Chung Lieh

AU - Tsao, Hsuan Ming

AU - Lin, Yenn Jiang

AU - Yun, Chun Ho

AU - Lai, Yau Huei

AU - Chang, Shih Lin

AU - Lo, Li Wei

AU - Hu, Yu Feng

AU - Tuan, Ta Chuan

AU - Chang, Hung Yu

AU - Kuo, Jen Yuan

AU - Yeh, Hung I.

AU - Wu, Tsu Juey

AU - Hsieh, Ming Hsiung

AU - Yu, Wen Chung

AU - Chen, Shih Ann

PY - 2013/9/16

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N2 - Objectives:Epicardial fat was closely related to atrial fibrillation (AF). Transthoracic echocardiography (TTE) has been proposed to be a convenient imaging tool in assessing epicardial adipose tissue (EAT). The goal of the present study was to investigate whether the EAT thickness measured on TTE was a useful parameter in predicting procedural outcomes of AF ablations.Methods and Results:A total of 227 paroxysmal AF (PAF) and 56 non-paroxysmal AF (non-PAF) patients receiving catheter ablations from 2008-2010 were enrolled. Echocardiography-derived regional EAT thickness from parasternal long-axis view was quantified for each patient. Free of recurrence was defined as the absence of atrial arrhythmias without using antiarrhythmic agents after ablations. The mean EAT thickness of the study population was 6.1 ± 0.8 mm. Non-PAF patients had a thicker EAT than that of PAF patients (7.0 ± 0.7 mm versus 5.9 ± 0.7 mm, p value 2 score, left atrial diameter and EAT thickness were independent predictors of recurrence after catheter ablations. At a cutoff value of 6 mm for PAF and 6.9 mm for non-PAF, the measurement of EAT thickness could help us to identify patients at risk of recurrences.Conclusions:EAT thickness may serve as a useful parameter in predicting recurrences after AF ablations. Compared to other imaging modalities, TTE can be an alternative choice with less cost and time in assessing the effects of EAT on ablation outcomes.

AB - Objectives:Epicardial fat was closely related to atrial fibrillation (AF). Transthoracic echocardiography (TTE) has been proposed to be a convenient imaging tool in assessing epicardial adipose tissue (EAT). The goal of the present study was to investigate whether the EAT thickness measured on TTE was a useful parameter in predicting procedural outcomes of AF ablations.Methods and Results:A total of 227 paroxysmal AF (PAF) and 56 non-paroxysmal AF (non-PAF) patients receiving catheter ablations from 2008-2010 were enrolled. Echocardiography-derived regional EAT thickness from parasternal long-axis view was quantified for each patient. Free of recurrence was defined as the absence of atrial arrhythmias without using antiarrhythmic agents after ablations. The mean EAT thickness of the study population was 6.1 ± 0.8 mm. Non-PAF patients had a thicker EAT than that of PAF patients (7.0 ± 0.7 mm versus 5.9 ± 0.7 mm, p value 2 score, left atrial diameter and EAT thickness were independent predictors of recurrence after catheter ablations. At a cutoff value of 6 mm for PAF and 6.9 mm for non-PAF, the measurement of EAT thickness could help us to identify patients at risk of recurrences.Conclusions:EAT thickness may serve as a useful parameter in predicting recurrences after AF ablations. Compared to other imaging modalities, TTE can be an alternative choice with less cost and time in assessing the effects of EAT on ablation outcomes.

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