Environmental factors association between asthma and acute bronchiolitis in young children - A perspective cohort study

Hui-Wen Lin, Sheng-Chieh Lin

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Acute bronchiolitis and asthma are respiratory tract diseases of childhood that are characterized by wheezing. However, the diagnosis of asthma is difficult in patients younger than 2 years. We evaluated the association between asthma or acute bronchiolitis and various risk factors in young children. This perspective cohort study included a study group of children younger than 2 years with a recorded diagnosis of acute bronchiolitis (N04,586) as well as a control group (N04,263). Children in both groups were registered between January 1, 2004 and December 31, 2004, on the Taiwan Longitudinal Health Insurance Database (2005), and each child was followed in our study until December 31, 2006, using data from the same source. Of the 8,849 children in our study, 355 experienced asthma during the 3-year follow-up period. Among these 355 asthma patients, 332 children (29.1 per 1,000 person-years, 95% CI 26.2-36.4) belonged to the acute bronchiolitis cohort and 23 children (2.0 per 1,000 person-years, 95% CI 13.3-29.9) belonged to the comparison cohort. Cox proportional hazard regression analysis showed that children with acute bronchiolitis were more likely to have asthma than the control population, after adjustment for potential confounders (adjusted hazard ratio [HR] 13.55, 95% CI 8.87-20.71). Boys with acute bronchiolitis had a higher HR for asthma than girls during the 3-year follow-up. Children with acute bronchiolitis who lived in rural areas had a 1.49 HR for asthma compared with their urban counterparts. Children living in the northern region of Taiwan had a higher HR ratio than those in other regions. Sex, urbanization, and geographic region all showed significant associations with acute bronchiolitis and asthma. Based on the asthma-free survival curves of Kaplan-Meier analysis in our study, young children with acute bronchiolitis should be monitored for 2 years to prevent them from developing asthma. This was the first study to evaluate the length of time for which acute bronchiolitis poses a risk for the development of asthma in young children. © Springer-Verlag 2012.
Original languageEnglish
Pages (from-to)1645-1650
Number of pages6
JournalEuropean Journal of Pediatrics
Volume171
Issue number11
DOIs
Publication statusPublished - 2012

Fingerprint

Bronchiolitis
Cohort Studies
Asthma
Taiwan
Respiratory Tract Diseases
Urbanization
Information Storage and Retrieval
Respiratory Sounds
Kaplan-Meier Estimate
Health Insurance
Regression Analysis

Keywords

  • Acute bronchiolitis
  • Asthma
  • Bootstrap sensitivity analysis
  • Epidemiology
  • Risk factors
  • article
  • asthma
  • bronchiolitis
  • child
  • childhood disease
  • cohort analysis
  • controlled study
  • disease association
  • disease course
  • environmental factor
  • female
  • follow up
  • geographic origin
  • human
  • major clinical study
  • male
  • priority journal
  • rural area
  • sex difference
  • Taiwan
  • urban area
  • urbanization
  • Acute Disease
  • Adolescent
  • Bronchiolitis
  • Case-Control Studies
  • Child
  • Child, Preschool
  • Databases, Factual
  • Female
  • Follow-Up Studies
  • Humans
  • Incidence
  • Kaplan-Meier Estimate
  • Male
  • Proportional Hazards Models
  • Prospective Studies
  • Risk Factors
  • Rural Health
  • Sex Factors
  • Urban Health

Cite this

Environmental factors association between asthma and acute bronchiolitis in young children - A perspective cohort study. / Lin, Hui-Wen; Lin, Sheng-Chieh.

In: European Journal of Pediatrics, Vol. 171, No. 11, 2012, p. 1645-1650.

Research output: Contribution to journalArticle

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abstract = "Acute bronchiolitis and asthma are respiratory tract diseases of childhood that are characterized by wheezing. However, the diagnosis of asthma is difficult in patients younger than 2 years. We evaluated the association between asthma or acute bronchiolitis and various risk factors in young children. This perspective cohort study included a study group of children younger than 2 years with a recorded diagnosis of acute bronchiolitis (N04,586) as well as a control group (N04,263). Children in both groups were registered between January 1, 2004 and December 31, 2004, on the Taiwan Longitudinal Health Insurance Database (2005), and each child was followed in our study until December 31, 2006, using data from the same source. Of the 8,849 children in our study, 355 experienced asthma during the 3-year follow-up period. Among these 355 asthma patients, 332 children (29.1 per 1,000 person-years, 95{\%} CI 26.2-36.4) belonged to the acute bronchiolitis cohort and 23 children (2.0 per 1,000 person-years, 95{\%} CI 13.3-29.9) belonged to the comparison cohort. Cox proportional hazard regression analysis showed that children with acute bronchiolitis were more likely to have asthma than the control population, after adjustment for potential confounders (adjusted hazard ratio [HR] 13.55, 95{\%} CI 8.87-20.71). Boys with acute bronchiolitis had a higher HR for asthma than girls during the 3-year follow-up. Children with acute bronchiolitis who lived in rural areas had a 1.49 HR for asthma compared with their urban counterparts. Children living in the northern region of Taiwan had a higher HR ratio than those in other regions. Sex, urbanization, and geographic region all showed significant associations with acute bronchiolitis and asthma. Based on the asthma-free survival curves of Kaplan-Meier analysis in our study, young children with acute bronchiolitis should be monitored for 2 years to prevent them from developing asthma. This was the first study to evaluate the length of time for which acute bronchiolitis poses a risk for the development of asthma in young children. {\circledC} Springer-Verlag 2012.",
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author = "Hui-Wen Lin and Sheng-Chieh Lin",
note = "被引用次數:2 Export Date: 7 April 2016 CODEN: EJPED 通訊地址: Lin, S.-C.; Department of Pediatrics, Shuang Ho Hospital, Taipei Medical University, No.291, Zhongzheng Road, Zhonghe District, New Taipei City 23561, Taiwan; 電子郵件: jacklinmails@yahoo.com.tw 參考文獻: Subcommittee on diagnosis and management of bronchiolitis (2006) Pediatrics, 118 (4), pp. 1774-1793. , American Academy Of Pediatrics; Amirav, I., Luder, A.S., Kruger, N., A double-blind, placebo-controlled, randomized trial of montelukast for acute bronchiolitis (2008) Pediatrics, 122 (6), pp. e1249-e1255; Carroll, K.N., Wu, P., Gebretsadik, T., Season of infant bronchiolitis and estimates of subsequent risk and burden of early childhood asthma (2009) J Allergy Clin Immunol, 123 (4), pp. 964-966; Castro, M., Schweiger, T., Yin-Declue, H., Cytokine response after severe respiratory syncytial virus bronchiolitis in early life (2008) J Allergy Clin Immunol, 122 (4), pp. 726-733; Da Dalt, L., Callegaro, S., Carraro, S., Andreola, B., Corradi, M., Baraldi, E., Nasal lavage leukotrienes in infants with RSV bronchiolitis (2007) Pediatr Allergy Immunol, 18 (1), pp. 100-104; Efron, B., Better bootstrap confidence intervals (1987) J Am Stat Assoc, 82 (397), pp. 171-185; Efron, B., Tibshirani, R., (1993) An Introduction to the Bootstrap, , Chapman & Hall, New York; Ehlenfield, D.R., Cameron, K., Welliver, R.C., Eosinophilia at the time of respiratory syncytial virus bronchiolitis predicts childhood reactive airway disease (2000) Pediatrics, 105 (1 PART 1), pp. 79-83; Everard, M.L., Acute bronchiolitis and croup (2009) Pediatr Clin N Am, 56 (1), pp. 119-133; Frischer, T., Halmerbauer, G., Gartner, C., Eosinophilderived proteins in nasal lavage fluid of neonates of allergic parents and the development of respiratory symptoms during the first 6 months of life (2000) Allergy, 55 (8), pp. 773-777; Gern, J.E., Busse, W.W., The role of viral infections in the natural history of asthma (2000) J Allergy Clin Immunol, 106 (2), pp. 201-212; Goetghebuer, T., Isles, K., Moore, C., Thomson, A., Kwiatkowski, D., Hull, J., Genetic predisposition to wheeze following respiratory syncytial virus bronchiolitis (2004) Clin Exp Allergy, 34 (5), pp. 801-803; Halfhide, C., Innate immune response and bronchiolitis and preschool recurrent wheeze (2008) Paediatr Respir Rev, 9 (4), pp. 251-262; Kim, C.K., Kim, S.W., Park, C.S., Bronchoalveolar lavage cytokine profiles in acute asthma and acute bronchiolitis (2003) J Allergy Clin Immunol, 112 (1), pp. 64-71; Kim, C., Choi, J., Kim, H.B., A randomized intervention of Montelukast for post-bronchiolitis: Effect on eosinophil degranulation (2010) J Pediatr, 156 (5), pp. 749-754; Koponen, P., Helminen, M., Paassilta, M., Luukkaala, T., Korppi, M., Preschool asthma after bronchiolitis in infancy (2012) Eur Respir J, 39 (1), pp. 76-80; Lash, T.L., Fink, A.K., Semi-automated sensitivity analysis to assess systematic errors in observational data (2003) Epidemiology, 14 (4), pp. 451-458; Lin, S.C., Chuang, Y.H., Yang, Y.H., Chiang, B.L., Decrease in interleukin-21 in children suffering with severe atopic dermatitis (2011) Pediatr Allergy Immunol, 22 (8), pp. 869-875; Mansbach, J.M., Camargo Jr., C.A., Respiratory viruses in bronchiolitis and their link to recurrent wheezing and asthma (2009) Clin Lab Med, 29 (4), pp. 741-755; (2006) Ref: National Health Insurance Research Databases, , http://www.nhri.org.tw/nhird/date_01.htm, Available From URL: [Accessed Mar.]; Renzi, P.M., Turgeon, J.P., Marcotte, J.E., Reduced interferon-γ production in infants with bronchiolitis and asthma (1999) Am J Respir Crit Care Med, 159 (5 PART 1), pp. 1417-1422; Sigures, N., Bjarnason, R., Sigurbergsson, F., Kjellman, B., Respiratory syncytial virus bronchiolitis in infancy is an important risk factor for asthma and allergy at age 7 (2000) Am J Respir Crit Care Med, 161 (5), pp. 1501-1507; Singh, A.M., Moore, P.E., Gern, J.E., Bronchiolitis to asthma: A review and call for studies of gene-virus interactions in asthma causation (2007) Am J Respir Crit Care Med, 175 (2), pp. 108-119; Zorc, J.J., Bronchiolitis: Recent evidence on diagnosis and management (2010) Pediatrics, 125 (2), pp. 342-349",
year = "2012",
doi = "10.1007/s00431-012-1788-3",
language = "English",
volume = "171",
pages = "1645--1650",
journal = "European Journal of Pediatrics",
issn = "0340-6199",
publisher = "Springer Verlag",
number = "11",

}

TY - JOUR

T1 - Environmental factors association between asthma and acute bronchiolitis in young children - A perspective cohort study

AU - Lin, Hui-Wen

AU - Lin, Sheng-Chieh

N1 - 被引用次數:2 Export Date: 7 April 2016 CODEN: EJPED 通訊地址: Lin, S.-C.; Department of Pediatrics, Shuang Ho Hospital, Taipei Medical University, No.291, Zhongzheng Road, Zhonghe District, New Taipei City 23561, Taiwan; 電子郵件: jacklinmails@yahoo.com.tw 參考文獻: Subcommittee on diagnosis and management of bronchiolitis (2006) Pediatrics, 118 (4), pp. 1774-1793. , American Academy Of Pediatrics; Amirav, I., Luder, A.S., Kruger, N., A double-blind, placebo-controlled, randomized trial of montelukast for acute bronchiolitis (2008) Pediatrics, 122 (6), pp. e1249-e1255; Carroll, K.N., Wu, P., Gebretsadik, T., Season of infant bronchiolitis and estimates of subsequent risk and burden of early childhood asthma (2009) J Allergy Clin Immunol, 123 (4), pp. 964-966; Castro, M., Schweiger, T., Yin-Declue, H., Cytokine response after severe respiratory syncytial virus bronchiolitis in early life (2008) J Allergy Clin Immunol, 122 (4), pp. 726-733; Da Dalt, L., Callegaro, S., Carraro, S., Andreola, B., Corradi, M., Baraldi, E., Nasal lavage leukotrienes in infants with RSV bronchiolitis (2007) Pediatr Allergy Immunol, 18 (1), pp. 100-104; Efron, B., Better bootstrap confidence intervals (1987) J Am Stat Assoc, 82 (397), pp. 171-185; Efron, B., Tibshirani, R., (1993) An Introduction to the Bootstrap, , Chapman & Hall, New York; Ehlenfield, D.R., Cameron, K., Welliver, R.C., Eosinophilia at the time of respiratory syncytial virus bronchiolitis predicts childhood reactive airway disease (2000) Pediatrics, 105 (1 PART 1), pp. 79-83; Everard, M.L., Acute bronchiolitis and croup (2009) Pediatr Clin N Am, 56 (1), pp. 119-133; Frischer, T., Halmerbauer, G., Gartner, C., Eosinophilderived proteins in nasal lavage fluid of neonates of allergic parents and the development of respiratory symptoms during the first 6 months of life (2000) Allergy, 55 (8), pp. 773-777; Gern, J.E., Busse, W.W., The role of viral infections in the natural history of asthma (2000) J Allergy Clin Immunol, 106 (2), pp. 201-212; Goetghebuer, T., Isles, K., Moore, C., Thomson, A., Kwiatkowski, D., Hull, J., Genetic predisposition to wheeze following respiratory syncytial virus bronchiolitis (2004) Clin Exp Allergy, 34 (5), pp. 801-803; Halfhide, C., Innate immune response and bronchiolitis and preschool recurrent wheeze (2008) Paediatr Respir Rev, 9 (4), pp. 251-262; Kim, C.K., Kim, S.W., Park, C.S., Bronchoalveolar lavage cytokine profiles in acute asthma and acute bronchiolitis (2003) J Allergy Clin Immunol, 112 (1), pp. 64-71; Kim, C., Choi, J., Kim, H.B., A randomized intervention of Montelukast for post-bronchiolitis: Effect on eosinophil degranulation (2010) J Pediatr, 156 (5), pp. 749-754; Koponen, P., Helminen, M., Paassilta, M., Luukkaala, T., Korppi, M., Preschool asthma after bronchiolitis in infancy (2012) Eur Respir J, 39 (1), pp. 76-80; Lash, T.L., Fink, A.K., Semi-automated sensitivity analysis to assess systematic errors in observational data (2003) Epidemiology, 14 (4), pp. 451-458; Lin, S.C., Chuang, Y.H., Yang, Y.H., Chiang, B.L., Decrease in interleukin-21 in children suffering with severe atopic dermatitis (2011) Pediatr Allergy Immunol, 22 (8), pp. 869-875; Mansbach, J.M., Camargo Jr., C.A., Respiratory viruses in bronchiolitis and their link to recurrent wheezing and asthma (2009) Clin Lab Med, 29 (4), pp. 741-755; (2006) Ref: National Health Insurance Research Databases, , http://www.nhri.org.tw/nhird/date_01.htm, Available From URL: [Accessed Mar.]; Renzi, P.M., Turgeon, J.P., Marcotte, J.E., Reduced interferon-γ production in infants with bronchiolitis and asthma (1999) Am J Respir Crit Care Med, 159 (5 PART 1), pp. 1417-1422; Sigures, N., Bjarnason, R., Sigurbergsson, F., Kjellman, B., Respiratory syncytial virus bronchiolitis in infancy is an important risk factor for asthma and allergy at age 7 (2000) Am J Respir Crit Care Med, 161 (5), pp. 1501-1507; Singh, A.M., Moore, P.E., Gern, J.E., Bronchiolitis to asthma: A review and call for studies of gene-virus interactions in asthma causation (2007) Am J Respir Crit Care Med, 175 (2), pp. 108-119; Zorc, J.J., Bronchiolitis: Recent evidence on diagnosis and management (2010) Pediatrics, 125 (2), pp. 342-349

PY - 2012

Y1 - 2012

N2 - Acute bronchiolitis and asthma are respiratory tract diseases of childhood that are characterized by wheezing. However, the diagnosis of asthma is difficult in patients younger than 2 years. We evaluated the association between asthma or acute bronchiolitis and various risk factors in young children. This perspective cohort study included a study group of children younger than 2 years with a recorded diagnosis of acute bronchiolitis (N04,586) as well as a control group (N04,263). Children in both groups were registered between January 1, 2004 and December 31, 2004, on the Taiwan Longitudinal Health Insurance Database (2005), and each child was followed in our study until December 31, 2006, using data from the same source. Of the 8,849 children in our study, 355 experienced asthma during the 3-year follow-up period. Among these 355 asthma patients, 332 children (29.1 per 1,000 person-years, 95% CI 26.2-36.4) belonged to the acute bronchiolitis cohort and 23 children (2.0 per 1,000 person-years, 95% CI 13.3-29.9) belonged to the comparison cohort. Cox proportional hazard regression analysis showed that children with acute bronchiolitis were more likely to have asthma than the control population, after adjustment for potential confounders (adjusted hazard ratio [HR] 13.55, 95% CI 8.87-20.71). Boys with acute bronchiolitis had a higher HR for asthma than girls during the 3-year follow-up. Children with acute bronchiolitis who lived in rural areas had a 1.49 HR for asthma compared with their urban counterparts. Children living in the northern region of Taiwan had a higher HR ratio than those in other regions. Sex, urbanization, and geographic region all showed significant associations with acute bronchiolitis and asthma. Based on the asthma-free survival curves of Kaplan-Meier analysis in our study, young children with acute bronchiolitis should be monitored for 2 years to prevent them from developing asthma. This was the first study to evaluate the length of time for which acute bronchiolitis poses a risk for the development of asthma in young children. © Springer-Verlag 2012.

AB - Acute bronchiolitis and asthma are respiratory tract diseases of childhood that are characterized by wheezing. However, the diagnosis of asthma is difficult in patients younger than 2 years. We evaluated the association between asthma or acute bronchiolitis and various risk factors in young children. This perspective cohort study included a study group of children younger than 2 years with a recorded diagnosis of acute bronchiolitis (N04,586) as well as a control group (N04,263). Children in both groups were registered between January 1, 2004 and December 31, 2004, on the Taiwan Longitudinal Health Insurance Database (2005), and each child was followed in our study until December 31, 2006, using data from the same source. Of the 8,849 children in our study, 355 experienced asthma during the 3-year follow-up period. Among these 355 asthma patients, 332 children (29.1 per 1,000 person-years, 95% CI 26.2-36.4) belonged to the acute bronchiolitis cohort and 23 children (2.0 per 1,000 person-years, 95% CI 13.3-29.9) belonged to the comparison cohort. Cox proportional hazard regression analysis showed that children with acute bronchiolitis were more likely to have asthma than the control population, after adjustment for potential confounders (adjusted hazard ratio [HR] 13.55, 95% CI 8.87-20.71). Boys with acute bronchiolitis had a higher HR for asthma than girls during the 3-year follow-up. Children with acute bronchiolitis who lived in rural areas had a 1.49 HR for asthma compared with their urban counterparts. Children living in the northern region of Taiwan had a higher HR ratio than those in other regions. Sex, urbanization, and geographic region all showed significant associations with acute bronchiolitis and asthma. Based on the asthma-free survival curves of Kaplan-Meier analysis in our study, young children with acute bronchiolitis should be monitored for 2 years to prevent them from developing asthma. This was the first study to evaluate the length of time for which acute bronchiolitis poses a risk for the development of asthma in young children. © Springer-Verlag 2012.

KW - Acute bronchiolitis

KW - Asthma

KW - Bootstrap sensitivity analysis

KW - Epidemiology

KW - Risk factors

KW - article

KW - asthma

KW - bronchiolitis

KW - child

KW - childhood disease

KW - cohort analysis

KW - controlled study

KW - disease association

KW - disease course

KW - environmental factor

KW - female

KW - follow up

KW - geographic origin

KW - human

KW - major clinical study

KW - male

KW - priority journal

KW - rural area

KW - sex difference

KW - Taiwan

KW - urban area

KW - urbanization

KW - Acute Disease

KW - Adolescent

KW - Bronchiolitis

KW - Case-Control Studies

KW - Child

KW - Child, Preschool

KW - Databases, Factual

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Incidence

KW - Kaplan-Meier Estimate

KW - Male

KW - Proportional Hazards Models

KW - Prospective Studies

KW - Risk Factors

KW - Rural Health

KW - Sex Factors

KW - Urban Health

U2 - 10.1007/s00431-012-1788-3

DO - 10.1007/s00431-012-1788-3

M3 - Article

VL - 171

SP - 1645

EP - 1650

JO - European Journal of Pediatrics

JF - European Journal of Pediatrics

SN - 0340-6199

IS - 11

ER -