Entrapment of bioactive compounds within native albumin beads

III. Evaluation of parameters affecting drug release

M. T. Sheu, T. D. Sokoloski

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

A simple and easily controlled method for preparing microbeads has been developed using a w/o emulsion technique. Under constant process variables (temperature, stirring, etc.), the formulation variables associated with the oil phase that can be altered that affect the size of beads produced are density, viscosity, and interfacial tension. Viscosity and interfacial tension were found to be important factors. Increasing the viscosity of the oil phase decreases the mean size and size distribution of the microbeads produced and results in an increase in the release rate of l-norgestrel. Decreasing the interfacial tension results in an increase in release rate. Since simple mixtures of oleic acid and light mineral oil offer a series of oil phases with different interfacial tensions but similar viscosity, it should be possible to prepare microbeads having a desired release rate by simply varying the mixture of oils. Decreasing temperature translates into an increase in release rate of drug through a viscosity effect. Increasing the amount of drug added decreases release rate.

Original languageEnglish
Pages (from-to)259-265
Number of pages7
JournalJournal of Parenteral Science and Technology
Volume40
Issue number6
Publication statusPublished - 1986
Externally publishedYes

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Viscosity
Surface Tension
Albumins
Oils
Microspheres
Mineral Oil
Levonorgestrel
Temperature
Oleic Acid
Emulsions
Drug Liberation
Light
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

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